57 results about "Gel Dosage Form" patented technology

The present invention provides a composition for forming a compressed solid dosage form that is a free-flowing compressible admixture of simethicone, an adsorbant, and an optional active agent, wherein the weight ratio of simethicone to adsorbent is at least 1:2.22. Also included are solid dosage forms made from a free-flowing compressible admixture of simethicone, an adsorbant, and an optional active agent, wherein the weight ratio of simethicone to adsorbent is at least 1:2.22.

The present invention relates to novel tablet dosage forms and methods of preparing these forms, which can be used for different classes of pharmaceutical active ingredients posing stability issues in a single unit system. The dosage form includes a first layer, which includes a tablet of one or more active pharmaceutical ingredients, which is inlayed in the first layer along with other pharmaceutically acceptable excipients, and a second layer that includes one or more active pharmaceutical ingredients optionally with other pharmaceutically acceptable excipients.

The present application provides a dosage form and related methods for making the dosage form. The dosage form generally comprises a hydrophilic active ingredient, a plurality of solid, porous microcarriers, each having a hydrophobic surface, an optional hydrophobic encapsulant, and a hydrophilic delivery agent, wherein (i) the hydrophilic active ingredient is associated with the plurality of solid, porous microcarriers, (ii) the plurality of solid, porous microcarriers is encapsulated by the hydrophobic encapsulant, and (iii) the hydrophilic delivery agent is physically separated from a majority of the hydrophilic active ingredient by a boundary between the hydrophilic delivery agent and the hydrophobic encapsulant. In some embodiments, the dosage form is for topical application. In some additional embodiments, the plurality of solid, porous microcarriers is formed by modifying the microcarriers to increase their hydrophobicity.

A novel edible polymer based film dosage form manufactured using natural, synthetic, semisynthetic, pharmaceutically acceptable polymers addressing the issues of swallowing difficulties (Dysphagia and Dynaphagia), of tablet or capsule dosage forms and handling and storage difficulties associated with liquid dosage forms, that also includes materials such as emulsifying agents, suspending agents, buffering agents, effervescence agents, colorants, flavorants, sweetners and specified amounts of bioactive agents preferably having perforations in the body of the dosage form enabling it to disperse/dissolve rapidly upon application by the subject. A flexible film dosage form to accommodate higher drug loads without compromising the fast dispersing/dissolving characteristics is presented. The perforated film system is enabled to be used in various applications such as oral, mucosal and external environments. The perforated film dosage form therefore, additionally allows the usage of polymers that would otherwise have not been used due to insolubility or limited solubility in water.

The present invention relates to methods that facilitate the oral administration of active drugs to a patient. Specifically, the methods of the present invention may utilize compositions comprising an active drug and a gelling agent that provides an easily consumable gel dosage form and the active drug is homogenously mixed within the gel.

The present invention is a solid dosage form of a doxycycline metal complex. The present invention also includes a process for making a doxycycline metal complex in a solid dosage form. The process comprises the steps of (i) providing an aqueous solution of doxycycline or a physiologically acceptable salt thereof; (ii) admixing a metal salt with the aqueous solution; (iii) admixing a base to increase the pH of the aqueous solution, thereby forming a suspension of doxycycline metal; and (iv) drying the suspension, thereby forming a dry granulation of doxycycline metal complex.

The invention discloses a temperature sensitive type instant molding gel system that includes poly-sorbate as gelatinizing temperature adjusting agent, and also could use poly-sorbate with other gelatinizing temperature adjusting agent. By adjusting the content of poly-sorbate, the adjustable range of gelling temperature would be expanded, and the solid content in system would be decreased, and the cost would be lowered. The invention could be used in normal medicine.

The invention discloses royal jelly acid containing antibacterial biological dressings as well as a preparation method and application thereof. One of the antibacterial biological dressings comprises the following ingredients in percentage by weight: 0.01-20% of royal jelly acid, 0.01-1% of a stabilizer, 1-5% of chitosan, alginate, polyving akohol or collagen and the balance of a matrix, wherein the stabilizer is alkyl trimethyl ammonium salt, multi-alkyl dimethyl ammonium salt or a betaine-type surfactant. Through the combination of royal jelly acid with one or more of chitosan, alginate, polyving akohol and collagen, a series of the antibacterial biological dressings of the solution/solvent type, the gel type, the cream type, the dressing type, the powder type and the patch type are prepared, can be used for treating infectious wounds, surgical wounds, burn wounds, scald wounds and the like, and are good in antibacterial property and broad in application prospect. The antibacterial biological dressings are reasonable in formula and convenient to prepare, and can control wound infection, keep the wounds wet and promote wound healing. More than one hundred of clinical cases prove that the effective rate of the antibacterial biological dressings reaches 95% or above.

The invention relates to a preparation technology and a production method of a new integrated dosage form of Linggui Zhugan Decoction. The raw material composition of the active ingredients is as follows: 12 parts of poria cocos, 9 parts of cassia twig, 6 parts of atractylodes rhizome and 6 parts of roasted licorice. Its production process includes: supersonic jet pulverization, alcohol water extraction, ultrasonic pulverization and extraction, water decoction and concentration, supersonic spray drying, nano grinding, high pressure emulsification, nano particle preparation, etc. The invention pays attention to the advantages of multi-synergy and multi-targeting embodied by the combination technology of nano-carriers. After large-scale production, the production cost can be greatly reduced, the product quality can be greatly improved, and the targeting and sustained release of the drug can be strengthened. It can be administered both internally and externally, and can be taken in four time periods according to the meridian flow and the flow of blood in the human body. Film-forming agents and transdermal agents can also be prepared and pasted on different parts of the human body according to the meridian flow and the flow of human Qi and blood, and can be directly absorbed through the skin.

The purpose of the invention is to provide a Pudilan children's antiviral oral pellet gel and a preparation method thereof. The preparation method comprises the following steps: adopting a gel matrix, extracting Radix Scutellariae, Herba Taraxaci, Corydalis bungeana Turcz. and isatis root, preparing pellets by using extracted effective components, and uniformly dispersing the pellets in a gel. The prepared gel can be a solid gel, a semisolid gel or a xerogel. The method effectively covers the bad smell of medicines, solves the mouthfeel problem of the medicines, and allows the sweet oral pellet gel loved by children to be prepared, and the sweet and smooth mouthfeel of the oral pellet gel makes children easily take the medicine. Traditional Chinese medicines are combined with the gel dosage form to improve the children's administration long-term single dosage form, and the oral pellet gel has the efficacies of heat clearing, detoxification, antibiosis and inflammation prevention, and also has the advantages of high content of the effective component, small administrating dosage, stable preparation and good curative effect.

The invention relates to a method of manufacture of fast-disintegrating solid dosage forms, characterized in that one or more structure building components in mixed solid powder form are dosed into cavities of blister packs or moulds, the remaining components dissolved in water dosed and added to the powder to form a moistened, plasticized mass, frozen to below −20° C. , and the water sublimed in high vacuum. In this way solid dosage forms are obtainable with a similar porous structure as usually result from freeze-drying processes, but the process requires much less water, which means considerably less time and less energy.

The invention provides a gel matrix and a preparation method thereof, and the gel matrix is used for preparation of gel dosage form drugs. The gel matrix provided by the invention includes: 0.5-10% of gel, 0.1%-10% of a tissue stabilizer, 0.1%-10% of a tissue repair agent, 0.5%-5% of a transdermal enhancer, 1%-10% of a non-water solvent with concentration higher than 90% and water, or a non-water solvent with concentration not more than 50%. The gel matrix provided by the invention has certain leveling property (uniformity), flexibility and moisture retention, so as to reduce the ''parching'' phenomenon. The gel matrix provided by the invention has strong ability of bearing and releasing drugs to satisfy quantitative addition of medicinal ingredient and guarantee stability and uniformity of drug storage and drug concentration in a course of treatment. The gel matrix provided by the invention can improve release rate, percutaneous absorption rate and safe treatment of the drug. The invention can increase tissue compatibility of the preparation, properly prolong action time and application frequency, so as to increase effectiveness and reduce the occurrence of local side effects.

The invention discloses a silicon-based wound repair hydrogel which is prepared from the following raw materials: 0.8-1.5g of carbomer, 40-60mL of glycerinum, 45-70mL of propylene glycol, 0.3-1.2g of gelatin, 6-16g of bioactive glass and 0.6-1.4g of pearl powder. A pearl powder component which contains calcium carbonate and various amino acids and is capable of providing local tissue of a wound with nutrients is added on the basis of a silicon-based wound repair mateiral, namely bioactive glass as a main repair material; meanwhile, the dosage form of the hydrogel is prepared under the condition of not adding water, so that the silicon-based wound repair material is prevented from degenerating in water, the dosage form has the characteristic that the hydrogel is painted for protecting the wound, and the silicon-based wound repair hydrogel is capable of keeping the wound moist, creating a low-oxygen and slight-acid environment, accelerating wound healing, absorbing seepage and cleaning the wound in an autolytic manner.

Provided are a solid dosage form comprising a solid dispersion that allows a drug in the preparation to be rapidly dissolved without compromising the solubility of the solid dispersion, and a method for producing the same. More specifically, provided is a solid dosage form comprising a solid dispersion, the dispersion comprising: a poorly soluble drug, a water-soluble polymer and a disintegrant, wherein the disintegrant is low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 μm and a specific surface area measured by BET method of at least 1.0 m²/g. Moreover, provided is a method for producing a solid dosage form comprising a solid dispersion, the method comprising steps of: spraying a water-soluble polymer solution in which a poorly soluble drug has been dispersed or dissolved, on a powder of low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 μm and a specific surface area measured by BET method of at least 1.0 m²/g and serving as a disintegrant and granulating the resultant; and drying.

The invention belongs to the technical field of medicine compositions, and discloses an external use medicine composition used for treating alopecia. The external use medicine composition comprises annular adrenocorticotrophic hormone release factor (CRF) antagonism peptide astressin B in effective treatment amount or acceptable salt on the pharmacy. The external use medicine composition is in a gel dosage form preferably and suitable for clinic use and industrialization production. In addition, the invention further discloses a method for preparing the external use medicine composition and application of the astressin B in effective treatment amount or the acceptable salt on the pharmacy to preparing the external use medicine composition used for treating the alopecia. According to the external use medicine composition, the problem of the alopecia for a long time can be effectively treated; and the external use medicine composition is safe, reliable, free of obvious skin irritants and free of sensitization.

The invention discloses a hemostatic antibacterial healing-promoting medical dressing containing lamiophlomis rotata iridoid glycoside active ingredient composite medical ACF and belongs to the technical field of preparation of medical dressings. The medical dressing is composed of the following components in percentage by weight: 1-20% of lamiophlomis rotata iridoid glycosides, 0.01-1% of hexadecyl trimethyl ammonium chloride, 1-5% of polyvinyl alcohol or collagen and the balance of a medical ACF matrix. The lamiophlomis rotata iridoid glycoside active ingredients and polyvinyl alcohol or collagen and the like are combined to be prepared into a solution dosage form and a gel dosage form, and the dosage forms are compounded with medical ACFs so as to prepare a series of external medical dressings. By utilizing the strong effects of the ACF for adsorbing wound exudates, activating a clotting mechanism and accelerating hemostasis, the 'synergistic effect' between the two is achieved, and the medical dressing can be used for treating infectious wounds, surgical trauma bleeding and the like, has excellent hemostatic antibacterial healing-promoting effects and also has wide application prospects. The medical dressing disclosed by the invention is reasonable in formula and convenient in preparation and has the effects of controlling the wound infection and promoting healing of the wound. The hemostasis models for wounds at artery and ventral aorta in ears of large-ear white rabbits and human-mouse livers prove that the effective rate reaches 95% or higher.

A controlled release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The coating around the core is water-permeable, water-insoluble and has at least one delivery port therethrough. A variety of geometric arrangements are disclosed.

Critical conditions of acute pancreatitis have high mortality. Trypsinization Theory is one of important pathogeneses of acute pancreatitis. Pancreatin inhibitor drugs, such as gabexate mesylate, ulinastatin and aprotinin, are selectively clinically applied against the mechanism. The routine administration mode of the drugs is intravenous injection, and has certain disadvantages. The invention provides an injectable temperature-sensitive gel preparation for treating acute pancreatitis. The dosage form of the above gel comprises a poloxamer polymer, a polylactide-co-glycolide/polyethylene glycol block copolymer, a polycaprolactam/polyethylene glycol block copolymer, a chitosan/beta-sodium glycerophosphate system, a chitosan/polyvinyl alcohol system or a chitosan-sodium bicarbonate system, or an arbitrary combination thereof. The gel has a reverse gelling characteristic, is a liquid at a low temperature, and converts to a semisolid state at a human body temperature. The invention also provides a preparation method of the injectable temperature-sensitive gel preparation for treating acute pancreatitis.

The invention discloses an antiviral hydrogel as well as a preparation method and application thereof. The hydrogel is directly formed by stacking and assembling nucleoside antiviral drugs layer by layer in the presence of metal ions. The antiviral hydrogel provided by the invention has antiviral activity equivalent to that of a free drug, can be prepared into a gel dosage form, and has a clinicalantiviral infection treatment application prospect.