Royal jelly acid containing antibacterial biological dressings as well as preparation method and application thereof
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The technology of biological dressing and royal jelly acid is applied in the field of biomedical materials, which can solve the problems of cell carcinogenesis, slowing down wound healing, wound and cytotoxicity, etc., and achieves the effects of convenient preparation, keeping the wound surface moist, and controlling the wound surface infection.
Inactive Publication Date: 2016-05-04
常州陀谱生物医学技术有限公司
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Silver nitrate is the most used silver salt, but NO in silver nitrate 3 - It is toxic to wounds and ...
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Embodiment 1
[0023] The antibacterial biological dressing containing royal jelly acid of the present invention is composed of the following components by weight percentage:
[0024]
[0025] The preparation method of the solution formulation: after mixing and dissolving royal jelly acid, stabilizer and chitosan, dissolving in purified water, filling in a plastic bottle, irradiating and sterilizing, it is the finished product.
[0026] The product is used to protect various wounds caused by burns, trauma, surgery, and infections, control wound infections, keep wounds moist, and promote wound healing. When in use, spray on the surface of the wound.
Embodiment 2
[0028] The antibacterial biological dressing containing royal jelly acid of the present invention is composed of the following components by weight percentage:
[0029]
[0030]
[0031] The preparation method of the gel dosage form: after mixing and dissolving royal jelly acid, stabilizer and collagen, dissolving in polyvinyl alcohol matrix, filling in a plastic tube, and irradiating and sterilizing, it is the finished product. When using, apply on the surface of the wound.
Embodiment 3
[0033] The antibacterial biological dressing containing royal jelly acid of the present invention is composed of the following components by weight percentage:
[0034]
[0035] The matrix component consists of the following components by weight:
[0036]
[0037] The preparation method of the cream formulation: after mixing and dissolving royal jelly acid, stabilizer, and alginate, dissolving in the matrix, filling in a plastic tube, and irradiating and sterilizing, it is the finished product. When using, apply on the surface of the wound.
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Abstract
The invention discloses royal jelly acid containing antibacterial biological dressings as well as a preparation method and application thereof. One of the antibacterial biological dressings comprises the following ingredients in percentage by weight: 0.01-20% of royal jelly acid, 0.01-1% of a stabilizer, 1-5% of chitosan, alginate, polyving akohol or collagen and the balance of a matrix, wherein the stabilizer is alkyl trimethyl ammonium salt, multi-alkyl dimethyl ammonium salt or a betaine-type surfactant. Through the combination of royal jelly acid with one or more of chitosan, alginate, polyving akohol and collagen, a series of the antibacterial biological dressings of the solution/solvent type, the gel type, the cream type, the dressing type, the powder type and the patch type are prepared, can be used for treating infectious wounds, surgical wounds, burn wounds, scald wounds and the like, and are good in antibacterial property and broad in application prospect. The antibacterial biological dressings are reasonable in formula and convenient to prepare, and can control wound infection, keep the wounds wet and promote wound healing. More than one hundred of clinical cases prove that the effective rate of the antibacterial biological dressings reaches 95% or above.
Description
Technical field [0001] The invention relates to a biomedical material, in particular to an antibacterial biological dressing containing royal jelly acid, a preparation method and application thereof, and is suitable for various wound treatments. Background technique [0002] The current development direction of wound dressing has gone through three stages: In the first stage, passive dressings (traditional dressings) such as absorbent cotton yarn, absorbent gauze, and synthetic fibers. Traditional dressings passively cover the wound surface, absorb exudate, and provide limited protection for the wound surface; the second stage, interactive dressings, such as polymer film, polymer foam dressing, hydrogel and hydrocolloid dressing, interact with each other There are many forms of interaction between the type dressing and the wound surface, such as absorbing exudate and toxic substances, allowing gas exchange, thereby creating an ideal environment for wound healing; a barrier outer ...
Claims
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