55results about How to "Keep the wound moist" patented technology

The invention discloses a liquid wound dressing which is characterized by comprising the following raw materials in parts by weight: 100-180 parts of a medical polymer film forming material, 0-20 parts of chitosan, 10-25 parts of polyethylene glycol 400 and 10-28 parts of glycerin, wherein the medical polymer film forming material is one in polyvinyl alcohol and polyvinyl butyral or a mixture of carbomer and one in the polyvinyl alcohol and the polyvinyl butyral. The liquid wound dressing can absorb the wound exudate, can effectively debride, maintains the surface of a wound to be wet, promotes the wound healing and is good in sterilizing effect.

The invention provides a glucan-based transparent hydrogel dressing and a preparation method thereof. The preparation method of the glucan-based transparent hydrogel dressing comprises the following steps: conducting a reaction between a glucan quaternary ammonium salt derivative and succinic anhydride; then promoting an obtained product to react with small molecules of amination, so that a macromonomer which contains illuminated cross-linking double bonds is obtained; mixing the macromonomer which contains illuminated cross-linking double bonds with an antibacterial agent and an initiating agent; conducting photo initiation so as to prepare a glucan-based transparent hydrogel; and combining the glucan-based transparent hydrogel with a polyurethane film by virtue of a bonding agent, so that the glucan-based transparent hydrogel dressing is prepared. The finished product (the glucan-based transparent hydrogel dressing) prepared by the invention not only can absorb a great amount of wound exudates so as to keep a wound surface wet, but also can avoid wound adhesion, so that the probability of wound infection is reduced and wound surface healing is promoted.

The invention relates to a hydrogel woundplast containing traditional Chinese medicine extracts and a preparation method thereof. The hydrogel woundplast comprises a back lining layer, a medicated hydrogel layer and a stripping layer. The preparation method comprises the following steps: uniformly mixing the following components in percentage by weight: 0.5-4.0% of chitosan, 1.0-3.0% of polyvinyl alcohol, 0.2-1.0% of gelatin, 1.0-3.0% of glycerol, 0.5-2.5% of menthol, 0.2-1.0% of coptis extract, 1.0-2.5% of honeysuckle flower extract, 15-25% of anhydrous ethanol and 50-80% of distilled water; performing cyclic refrigerating-melting treatment to obtain the medicated hydrogel layer; bonding the back lining layer on one side of the hydrogel layer; and bonding the stripping layer on the other side of the hydrogel layer. The hydrogel woundplast containing traditional Chinese medicine extracts is simple in structure and convenient to use, and can absorb wound surface exudates and keep wound wetness; and meanwhile, the hydrogel woundplast has the effects of resisting bacteria, diminishing inflammation and stopping bleeding, and can effectively accelerate wound healing.

The invention relates to a medical article, and mainly relates to a chitosan fluid dressing film for accelerating wound healing for skin burn, trauma, and body surface ulcers, and infection treatment. The chitosan fluid dressing film is prepared by using chitosan as a main raw material; the chitosan is dissolved with acids, and mixed with gelatin fully swelled in water; then glycerin and a silver salt solution are added; under the action of ultrasonic wave, simple substance silver exists in the fluid in a form of nanometer colloidal silver so as to obtain nanometer silver sol. The dressing film of the invention adopts chitosan as a main raw material, has wide-spectrum antibacterial properties, and can be used as dressing for skin modification and skin wound. A lot of -NH2 and -OH are contained in the molecules, which can form cage-shaped molecules with a structure like a net with metal ions through hydrogen bonds, and thus stable coordination is provided for silver ions. Chitosan adsorbed with silver ions has more effective bactericidal effect.

The invention discloses a copper-based MOF hydrogel functionalized antibacterial film as well as a preparation method and application thereof. The preparation method comprises the following steps thatfirstly, a natural polymer macromonomer is synthesized, wherein the natural polymer macromonomer is any one or more of a vinyl chitosan derivative, or vinyl chitosan derivative and methacrylic acid esterified gelatin; copper ions are loaded in cross-linked hydrogel of natural polymer-g-N-isopropylacrylamide in the form of copper-based metal organic framework nanoparticles, and the copper-based MOF hydrogel functionalized antibacterial film is prepared by virtue of nucleophilic addition reaction between active groups on the surface of a hydrogel matrix and isocyanate groups on the surface of amodified antibacterial film. According to the antibacterial film and the preparation method thereof, the temperature sensitivity and antibacterial property of the copper-based MOF functionalized hydrogel and the bacterium blocking capacity of the antibacterial film are combined, effective bonding between the antibacterial film and the functionalized hydrogel is achieved through physical and chemical effects, and the antibacterial film has relatively high physical and mechanical properties while having antibacterial and bacteriostatic effects.

The invention discloses a three-dimensional nanocomposite adhesive bandage as well as a preparation method and a use method thereof. The three-dimensional wound-protection layer of the adhesive bandage has a curved surface, and the curved surface is complementary to the uneven wound surface and comprises a nanobacterial cellulose frozen-dried membrane and an eletrospun chitosan-containing nanofiber film. The three-dimensional wound-protection layer can carry a part of liquid medicine. When in use, the adhesive bandage fully fits the wound surface, has air permeability, can keep the wound surface wet, has the functions of stop bleeding, inhibiting bacteria, promoting the healing of a wound and preventing the adhesion of the wound surface to the wound dressing and can be used widely. The adhesive bandage can well fit the concave wound surface and the convex wound surface, is applicable to the wet wound surface with many exudates, the dry wound surface which needs to be wetted by the wound dressing and the potential wound surface which needs protection, thereby being an ideal wound dressing.

The invention provides a stem cell sponge bracket, as well as a preparation method and application thereof, and relates to the technical field of biomaterials. The stem cell sponge bracket comprises ananometer fiber sponge and stem cells loaded on the nanometer fiber sponge. The stem cell sponge bracket disclosed by the invention has favorable compression rebound elasticity performance, so that massive wound transudate can be absorbed, the wound is kept to be moist, and the effects of protecting wound, bleeding stopping and promoting wound healing are achieved; besides, the three-dimensionalfiber structure has favorable mesh connectivity, larger internal surface area and larger aperture, so that the loading number of the stem cells can be improved; and in addition, the stem cell sponge bracket provided by the invention has favorable bioactivity, biodegradability and biocompatibility, so that an inflammatory reaction or an allergic reaction cannot be generated.

The invention discloses a skin wound repairing preparation which is prepared by dissolving hyaluronic acid, 4-dimethylamino pyridine, 1-(3-dimethylamino propyl)-3-ethyl carbodiimide hydrochloride in dimethyl sulfoxide, and performing magnetic stirring at the room temperature so as to obtain a hyaluronic acid solution; mixing pulullan with dimethyl sulfoxide, and uniformly stirring so as to obtain a pulullan solution; slowly dripping the pulullan solution into the hyaluronic acid solution to react for 4-48 hours at 40-80 DEG C, dialyzing the reaction liquid, and performing freeze-drying on the obtained dialysis liquid, thereby obtaining the skin wound repairing preparation. The skin wound repairing preparation disclosed by the invention has multiple effects of isolating bacteria, absorbing effusion of a wound surface, keeping the wound surface wet, promoting the wound surface to heal and the like, moreover is wide in preparation raw material resource, low in cost, gentle in synthesis condition, concise in production route, good in operability, and easy in production quality control, and most importantly has relatively higher security and clinical use values when being compared with a conventional similar product.

The invention belongs to the field of surgical dressing and specifically relates to a traditional Chinese medicine liquid dressing and a preparation method. The traditional Chinese medicine liquid dressing comprises the following components by weight percent: 1.0%-6.0% of film-forming material, 2.0%-4.0% of glycerinum, 0.5%-3.0% of menthol, 0.3%-1.0% of coptis chinensis extract, 1.0%-2.0% of honeysuckle extract and the balance of solvent. The traditional Chinese medicine liquid dressing provided by the invention is acquired according to the steps of mixing the above components in turn, uniformly stirring and filling. The traditional Chinese medicine liquid dressing provided by the invention has the advantages of simple component, short film-forming time, waterproof effect, good antibacterial effect, no drug-fast property and capability of boosting wound healing and shortening the wound healing time.

The invention discloses a medical dressing used for stopping bleeding of traumas. The medical dressing is mainly prepared from the following raw materials in parts by mass: 20-40 parts of polyurethane, 6-10 parts of polyethylene glycol, 1-3 parts of chitosan, 15-20 parts of herb of Japanese thistle, 10-14 parts of aizoon stonecrop herb, 6-12 parts of baikal skullcap root, 5-10 parts of rhizoma corydalis, 7-9 parts of peppermint, 11-13 parts of root of Chinese mahonia, 6-11 parts of incised notopterygium rhizome or root, 5-10 parts of root of littleleaf dogwood, 4-8 parts of cape jasmine fruit and 3-7 parts of fresh cockscomb flower. The medical dressing has the beneficial effects that the medical dressing has excellent properties and good elasticity and toughness, is well fit with wound surfaces, does not adhere to wounds, has good water absorptivity and moisture permeability and keeps the wound surfaces wet; the traditional Chinese medicine ingredients contained in the medical dressing have the activities of clearing away heat and toxic materials and diminishing inflammation and inhibiting bacteria and have the effects of promoting wound healing and preventing infection.

The invention discloses a traditional Chinese medicine chrisma agent and making method to treat burn, which comprises the following parts: rheum officinale, beeswax, sesame oil and medically acceptable base. The invention reduces the pain of burnt patient to heal the wound rapidly, which keeps the wound not wet and exposes without drying, therefore making the burnt tissue obtain fresh drug at constant density to release drug to the maximum degree.

The invention discloses a carbon quantum dot modified dual-network hydrogel, which is prepared by introducing kanamycin carbon quantum dots into a dual-network hydrogel system in a chemical crosslinking manner; the aperture of the carbon quantum dot modified dual-network hydrogel is 10 [mu] m-20 [mu] m, and the size of the kanamycin carbon quantum dots is 1 nm-5 nm. In addition, the invention also provides a preparation method of the hydrogel. The first layer of network of the carbon quantum dot modified dual-network hydrogel is a Schiff base bond formed by the reaction of an aldehyde group and an amino group, the second layer of network is a hydrogen bond formed by polyvinyl alcohol through a circulating low-temperature freezing method, the Schiff base bond and the hydrogen bond are both reversible dynamic covalent bonds, bond breakage can be realized in a wound inflammation microenvironment, and the carbon quantum dots are released, so the purposes of sterilization and drug resistance are achieved.

The invention discloses a glucose and enzyme double-response dressing for treating diabetic chronic wounds and a preparation method thereof, and the method comprises the following steps: adding an anti-inflammatory drug into a collagen solution to form a suspension containing the anti-inflammatory drug, mixing the suspension containing the anti-inflammatory drug with a system containing an emulsifier to form an emulsion system containing the anti-inflammatory drug, freezing the anti-inflammatory drug emulsion system, and mixing the anti-inflammatory drug emulsion system with a glutaraldehyde solution for reaction to obtain enzyme response collagen drug-loaded microspheres; mixing and reacting a system containing the enzyme response collagen drug-loaded microspheres, insulin and modified chitosan with a polyvinyl alcohol solution to obtain the glucose and enzyme double-response dressing for treating the chronic wound surface of the diabetes mellitus. The dressing prepared by the method disclosed by the invention has the characteristic of double response of glucose and matrix metalloproteinase-9, can effectively absorb tissue seepage and keep a wound moist, can perform intelligent drug delivery according to the characteristic that a diabetic foot ulcer wound has high glucose and MMP-9, and solves the two prominent problems of the wound; and the wound healing is accurately and efficiently promoted.

The invention discloses a burn and scald treating ointment and a preparation method thereof. The burn and scald treating ointment comprises the following raw materials in parts by weight: 5-15 parts of lithospermum, 5-15 parts of coptis chinensis, 5-15 parts of borax, 8-24 parts of gypsum, 250-750 parts of plant oil, 250-750 parts of beewax and 8-24 parts of red peony root. The invention further discloses the preparation method of the burn and scald treating ointment. The invention provides the burn and scald treating ointment which is short in treatment time, high in curative speed, free of sequelae, strong in antibacterial performance, anti-inflammatory, swelling-removing, convenient to use, high in therapeutic effect and low in cost and the preparation method thereof.

The Chinese medicine for external application for curing injury of skin is made from yellow wax 4-30g, wingless cockroach 0.5-3g, sesame oil 60-120g, bletilla tuber 10-20g and rhubarb 0.5-10g, and its preparation method includes: placing the bletilla tuber and rhubarb into sesame oil, heating and deep-frying until yellow, taking out bletilla tuber and rhubarb, placing the wingless cockroach into the seame oil, deep-frying until crisp and taking out the wingless cockroach, cooling liquid medicine to 80-120 deg.c, adding yellow wax and dissolving yellow wax completely to obtain the invented product which can be used not only for curing burn and scald, but also for curing dermal injuries of pinkeye, electric welding light radiation damaged eye, running sore and dermel ulcer, etc. and can obtain good therapeutic effect.

The invention discloses a polypeptide preloaded injectable self-repairing antibacterial hydrogel dressing and a preparation method thereof. The hydrogel dressing comprises a hydrogel combined with a fabric, wherein polypeptides for promoting migration of fibroblasts are distributed on the surface of the hydrogel and in the hydrogel. The preparation method comprises the following steps: selectivelyoxidizing glucans with different molecular weights into aldehyde glucans through an oxidizing agent; performing reacting on the aldehyde glucans with aliphatic amine to obtain partially alkylated glucans; then preparing the polypeptides through solid phase; and respectively dissolving the aldehyde glucans, adipic dihydrazide and the partially alkylated glucans into PBS buffer solutions, adding the polypeptides into the aldehyde glucan solution to preload the polypeptides synthesized through solid phase, mixing the three solutions according to a certain mass ratio to prepare the polypeptide preloaded injectable self-repairing antibacterial hydrogel, and finally preparing the dressing. The hydrogel dressing prepared by the method has good antibacterial performance, can reduce the chance ofwound infection, has dynamic self-repairing performance, can aim at irregular wounds, can keep the wound surface moist, and can accelerate wound healing.

The invention discloses a spray for treating scalds and burns and a preparation method thereof. The spray comprises white spirit, safflower, radix sophorae flavescentis and cortex periplocae. The preparation method specifically comprises the following steps: 1) selecting and cleaning of medicines; 2) soaking; 3) filtering and sub-packaging. The spray has the effects of relieving swelling and pain,promoting blood circulation, nourishing blood, astringing dampness, healing sores, promoting tissue regeneration, healing wounds, resisting bacteria, diminishing inflammation, relieving pain, protecting wounds, preventing infection and promoting rapid healing of wounds. The regeneration capacity of human cells is fully stimulated through the external medicines, muscle tissue is promoted to rapidly grow again, and therefore the treatment effect of short-term healing is achieved. The application method is simple, the wound surface of a patient is not treated, the spray is applied immediately, and pain is relieved within a short time. The external medicine is more direct in effect, simple in dressing change, less in pain and beneficial to observation of changes of the wound surface, a medicine film formed by the medicine on the wound surface and the wound surface are kept wet, no scar is left after healing, and hormone and toxic and side effects are avoided. The spray is used for burns and scalds of heat toxin skin burning, ultraviolet radiation injuries, electric shock injuries and the like.

The invention discloses a pharmaceutical composition for prevention of rectal carcinoma radioactive skin damage and an application thereof; the pharmaceutical composition is prepared from an active component and auxiliary materials; the active component is prepared by water extraction and alcohol precipitation of the following traditional Chinese medicine raw materials in parts by weight: 13-20 parts of potentilla fulgens wall, 12-18 parts of tribulus terrestris, 12-18 parts of mandarin orange seed, 13-20 parts of abelmoschus crinitus wall, 21-30 parts of herba lycopi, 21-30 parts of white atractylodes rhizome, 6-12 parts of fructus amomi, and 10-20 parts of herba hyperici. The pharmaceutical composition not only can delay the generation of radioactive skin damage, ensure smooth performing of radiation therapy and improve tolerability of patient skins on the cumulative dose of radiation, but also can promote healing of radioactive skin damage wound surfaces.