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Chitosan fluid dressing film

A fluid dressing film, chitosan technology, applied in the field of medical supplies, can solve the problems of low antibacterial activity and general biocompatibility, achieve good biocompatibility, promote accelerated healing, and good tissue compatibility. Effect

Active Publication Date: 2013-01-02
HANGZHOU CROR BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing fluid dressing films made of chitosan have low antibacterial activity and general biocompatibility

Method used

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  • Chitosan fluid dressing film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 Preparation of nano-silver sol

[0018] Materials and instruments: silver nitrate (analytical grade, purity 99.8%, Tianjin Wenda Rare and Precious Reagent Chemical Factory), glycerin (China Pharmaceutical Shanghai Chemical Reagent Company), water-soluble chitosan (pharmaceutical grade, Jinhu, Huantai County) Shell Products Co., Ltd.), purified water (self-made) QC-ROⅡ-0.5T / H two-stage reverse osmosis purified water equipment (Hangzhou Qicheng Purification Equipment Co., Ltd.), H-800 transmission electron microscope (Hitachi, Japan), UV- Model 2501 UV-Vis Spectrophotometer (Shimadzu), JF1204 Analytical Balance (Yuyao Jinnuo Balance Instrument Co., Ltd.).

[0019] Experimental method: Accurately weigh a certain amount of silver nitrate, add water to dissolve it, and put it into a brown volumetric flask for later use. Accurately weigh a certain amount of water-soluble chitosan, add water to dissolve, make a solution with a certain concentration, filter, and p...

Embodiment 2

[0037] Weigh chitosan, gelatin, glycerin and silver nitrate in a weight ratio of 10:10:2:1, mix silver nitrate with water to make a solution, dissolve chitosan with acid, and then mix with gelatin fully swollen by water, Then add glycerin and mix evenly, under stirring, slowly add silver nitrate solution to the above solution, so that the concentration of silver reaches 1000 mg·L -1 , stirred evenly, and then put the mixture in an ultrasonic instrument, set the ultrasonic power to 150W, and the time to 60min, under the action of ultrasonic waves, the prepared 1000 mg·L -1 The nano-silver particles are monodisperse spherical, the average particle size is below 10 nm and the particle size distribution is narrow, and they are uniformly dispersed in the chitosan fluid dressing in the form of colloid.

Embodiment 3

[0039] Weigh chitosan, gelatin, glycerin and silver nitrate in a weight ratio of 12:12:2:1.2, mix silver nitrate with water to make a solution, dissolve chitosan with acid, then mix with gelatin fully swollen by water, Then add glycerin and mix evenly, under stirring, slowly add silver nitrate solution to the above solution, so that the concentration of silver reaches 1200 mg·L -1 , stirred evenly, and then put the mixture in an ultrasonic instrument, set the ultrasonic power to 150W, and the time to 65min, under the action of ultrasonic waves, the prepared 1200 mg·L -1 The nano-silver particles are monodisperse spherical, the average particle size is below 10 nm and the particle size distribution is narrow, and they are uniformly dispersed in the chitosan fluid dressing in the form of colloid.

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Abstract

The invention relates to a medical article, and mainly relates to a chitosan fluid dressing film for accelerating wound healing for skin burn, trauma, and body surface ulcers, and infection treatment. The chitosan fluid dressing film is prepared by using chitosan as a main raw material; the chitosan is dissolved with acids, and mixed with gelatin fully swelled in water; then glycerin and a silver salt solution are added; under the action of ultrasonic wave, simple substance silver exists in the fluid in a form of nanometer colloidal silver so as to obtain nanometer silver sol. The dressing film of the invention adopts chitosan as a main raw material, has wide-spectrum antibacterial properties, and can be used as dressing for skin modification and skin wound. A lot of -NH2 and -OH are contained in the molecules, which can form cage-shaped molecules with a structure like a net with metal ions through hydrogen bonds, and thus stable coordination is provided for silver ions. Chitosan adsorbed with silver ions has more effective bactericidal effect.

Description

technical field [0001] The invention relates to a medical product, mainly a chitosan fluid dressing film for accelerating wound healing and infection treatment of skin burns, wounds and body surface ulcers. Background technique [0002] Silver has been used since ancient times to speed wound healing, treat infections, purify water and preserve beverages. The bactericidal mechanism of silver is different from chemically synthesized antibacterial agents. It works through the denaturation of bacterial proteins by heavy metal ions, so it has the characteristics of broad-spectrum bactericidal and less resistant to drugs. However, the antibacterial effect of silver in the metal state is weak, and the metallic silver is processed into nano-silver, due to the quantum effect, small size effect and large specific surface area characteristics of the nano-material itself, the nano-silver particles show extraordinary antibacterial properties. Ability to kill common bacteria, fungi, myco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/32A61L15/44
Inventor 童鑫霞
Owner HANGZHOU CROR BIOTECH
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