Thermo-sensitive filling gel preparation for rhinology, preparation method of thermo-sensitive filling gel preparation and application of thermo-sensitive filling gel preparation in operation on nasal cavity and paranasal sinuses
A gel preparation and temperature-sensitive technology, which is applied in the field of temperature-sensitive filling gel preparations, can solve the problems of secondary wounds, removal, and difficulty in placing sponges, and achieves the advantages of preventing infection, being convenient to use, and avoiding secondary injuries. Effect
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[0041] The preparation method of the nasal temperature-sensitive filling gel preparation of the present invention is simple, comprising the following steps:
[0042] (1) Mix the alkaline buffer system and chitosan evenly, then add cellulose and poloxamer thereto under stirring, and fully stir;
[0043] (2) The mixture was allowed to stand at room temperature until fully swollen, and then sterilized to obtain a thermosensitive filling gel preparation for nasal use.
[0044] In the above method, the alkaline buffer system is prepared according to the formula first, then the chitosan and the alkaline buffer system are mixed evenly, and then the cellulose and poloxamer are added under stirring, and stirred until they are fully dispersed and dissolved.
[0045] In the above step (2), the mixture was allowed to stand at room temperature for 72-100 hours to fully swell.
[0046] In the above-mentioned step (2), after the mixture is swollen, any method used in industry can be used fo...
Embodiment 1
[0050] The formulation of the nasal thermosensitive filling gel preparation is: 3% chitosan hydrochloride with a molecular weight of 400KDa, 0.3% hydroxypropyl cellulose, 15% poloxamer 407, and 81.7% alkaline buffer system. Among them, the alkaline buffer system is a phosphate buffer with a pH of 8. The buffer components and their contents in the gel preparation are: potassium dihydrogen phosphate 0.04%, disodium hydrogen phosphate 0.45%, sodium chloride 2%, chlorine Potassium chloride 0.06%, sodium hydroxide 0.01%, polyethylene glycol 4000.8%, water 78.34%.
[0051] The preparation method of thermosensitive rhinology filling gel preparation is:
[0052] (1) take each required raw material respectively by formula;
[0053] (2) mixing the components of the alkaline buffer system according to the proportions to form an alkaline buffer system;
[0054] (3) chitosan hydrochloride is added in the alkaline buffer system and stirred evenly;
[0055] (4) Add hydroxypropyl cellulose...
Embodiment 2
[0059]The formula of thermosensitive filling gel preparation for nose is: chitosan acetate with a molecular weight of 400KDa 6%, hydroxypropyl cellulose 0.6%, carboxymethyl cellulose 0.2%, poloxamer 40719%, alkali Sexual buffer system 74.2%. Among them, the alkaline buffer system is a phosphate buffer with a pH of 9. The buffer components and their contents in the gel preparation are: potassium dihydrogen phosphate 0.06%, disodium hydrogen phosphate 0.54%, sodium chloride 3.0%, chlorine Potassium chloride 0.10%, sodium hydroxide 0.05%, propylene glycol 1.5%, water 68.95%.
[0060] Referring to Example 1 for the preparation method, the pH of the obtained nasal temperature-sensitive filling gel preparation is 7.5.
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