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Chitosan wound dressing and preparation and application thereof

A kind of wound dressing, chitosan technology

Inactive Publication Date: 2017-10-10
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, researchers at home and abroad have done a lot of research on wound dressings, but in clinical treatment, sterile gauze is still used for dressing. This traditional gauze dressing mainly protects the wound, but hardly promotes the healing of the wound. and this type of dressing is easy to adhere to the wound, so it is very easy to cause secondary damage when changing the dressing; for small wounds, adhesive bandages are still the product of choice for people to often treat wounds. Adhesive bandages usually consist of a long Shaped adhesive plaster and a small piece of absorbent pad, but traditional bandages generally only temporarily stop bleeding and protect the wound surface, and should not be used for too long
If it is used for a long time, the outer layer of the band-aid is not air-permeable, which will make the wound and the skin around the wound turn white and soften, leading to secondary infection
[0004] According to incomplete statistics, there are more than 2,400 kinds of wound dressings currently on the market, but no specific dressing can be used for the entire wound healing process, and the choice of dressing should also be made according to the condition of the wound

Method used

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  • Chitosan wound dressing and preparation and application thereof
  • Chitosan wound dressing and preparation and application thereof
  • Chitosan wound dressing and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) Preparation of N-glycosylated chitosan: Weigh 4.0g of chitosan, add 200mL of 1% acetic acid aqueous solution, stir at room temperature (25-30°C) for 0.5h, wait for it to fully dissolve, then add 4.0 Chitosan amino equivalent fructose, after 7 hours of magnetic stirring reaction at 30-35 °C, add 1.7 g of sodium borohydride and reduce it at room temperature for 24 hours, and finally stop the reaction with 95% ethanol aqueous solution, and wash the precipitated product with absolute ethanol Wash 3 to 4 times, centrifuge to obtain a precipitate, and vacuum dry at 40°C to finally obtain N-glycosylated chitosan, which is stored in a desiccator for future use.

[0041] (2) The preparation method of the aloe water extract is as follows: select fresh aloe leaves, rinse them with deionized water, and mash them to obtain a homogenate. Take 100g of homogenate, sterilize at 95°C for 5-8min at high temperature, let it stand for cooling, ultrasonicate at 450W for 20-30min, centrif...

Embodiment 2

[0044] 1) Liquid chitosan wound dressing formula: 2.17g of N-glycosylated chitosan, 10mL of aloe water extract prepared in Example 1, 30mL of mass concentration 10% polyvinyl alcohol (polymerization degree 1750±50), polyethylene glycol Diol (polymerization degree 6000) 0.43g, glycerin 1.52mL, olive oil 1.52mL, povidone iodine (molecular weight 365) 3.91mL, mass concentration 30% hydrogen peroxide 3.91mL, lactic acid 0.65mL, menthol 0.43g, volume concentration 95 % ethanol aqueous solution 32.6mL, 5mg / mL physiological saline 21.74mL.

[0045] 2) The preparation steps of liquid chitosan wound dressing are as follows:

[0046] (1) According to the formula, weigh 2.17g of N-glycosylated chitosan, add 21.74mL of 5mg / mL normal saline, stir and dissolve at room temperature, then add 0.65mL of lactic acid to prepare N-glycosylated chitosan solution;

[0047] (2) Membrane solution preparation: weigh 0.30 g of polyvinyl alcohol according to the formula, add it to deionized water, heat...

Embodiment 3

[0051] 1) Liquid chitosan wound dressing formula: 2.27g of N-glycosylated chitosan, 10.45mL of alcoholic extract of aloe prepared in Example 1, 31.8mL of mass concentration 10% polyvinyl alcohol, 0.45g of polyethylene glycol, Glycerin 1.59mL, olive oil 1.59mL, povidone-iodine 4.09mL, mass concentration 30% hydrogen peroxide 3.18mL, lactic acid 0.68mL, menthol 0.45g, volume concentration 95% ethanol aqueous solution 30.9mL, 5mg / mL normal saline 22.7mL.

[0052] 2) The preparation steps of liquid chitosan wound dressing are as follows:

[0053] (1) According to the formula, weigh 2.27g of N-glycosylated chitosan, add 22.7mL of 5mg / mL normal saline, stir and dissolve at room temperature, then add 0.68mL of lactic acid to prepare N-glycosylated chitosan solution;

[0054] (2) Membrane solution preparation: weigh 3.18g of polyvinyl alcohol according to the formula, add it to deionized water, heat and stir at 90-100°C for 2-3 hours until completely dissolved, and prepare a 10% poly...

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Abstract

The invention discloses a chitosan wound dressing and preparation and application thereof. The chitosan wound dressing is prepared from the raw materials of N-glycosylated chitosan, aloe extract, polyvinyl alcohol aqueous solution with mass concentration of 10%, polyethylene glycol, glycerol, olive oil, povindone-iodine, hydrogen peroxide with mass concentration of 30%, lactic acid, menthol, ethanol aqueous solution with volume concentration of 95%, and 5 mg / mL normal saline. The applying type fluid wound dressing is applicable to protection and the like of skin abrasions and cuts, skin chaps, minor burns and scalds and sutured surgical wounds.

Description

(1) Technical field [0001] The invention relates to a biomedical dressing and a preparation method thereof. (2) Background technology [0002] In real life, people are often injured due to accidents, such as abrasions, bumps, knife cuts, stab wounds, and burns. Such skin trauma can easily cause bleeding, bleeding, and persistent pain. In addition, there are traumas such as decubitus ulcers and surgical wounds in the hospital. If these traumas are not treated properly, the healing time will be delayed and scars will be left in mild cases; Can cause various complications, such as tetanus, sepsis and so on. Therefore, trauma is a kind of disease that cannot be ignored. It is very necessary to carry out effective treatment and care for wounds on the skin surface, and actively carry out research on the treatment and repair of wounds. [0003] At present, researchers at home and abroad have done a lot of research on wound dressings, but in clinical treatment, sterile gauze is st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
Inventor 应国清易喻徐云霞梅建凤陈建澍张彦璐
Owner ZHEJIANG UNIV OF TECH
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