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Glucose and enzyme double-response dressing for treating chronic wound surface of diabetes mellitus and preparation method thereof

A technology for chronic wounds and glucose, which is applied in medical formulas, bandages, microcapsules, etc., can solve the problems of impaired regeneration of wound tissue, disordered glucose metabolism in diabetics, and low levels of glucose utilization, achieving precise and efficient wound healing and promoting Wound healing and keeping the wound moist

Active Publication Date: 2021-08-10
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The main characteristics of the physiological microenvironment of diabetic foot ulcer wounds are as follows: 1. Diabetic foot ulcer wounds have high glucose levels, which are more likely to cause infection, and diabetic patients have disordered glucose metabolism and low glucose utilization levels , leading to impaired regenerative function of wound tissue

Method used

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  • Glucose and enzyme double-response dressing for treating chronic wound surface of diabetes mellitus and preparation method thereof
  • Glucose and enzyme double-response dressing for treating chronic wound surface of diabetes mellitus and preparation method thereof
  • Glucose and enzyme double-response dressing for treating chronic wound surface of diabetes mellitus and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] This embodiment provides a method for preparing a glucose and enzyme dual-response dressing for treating diabetic chronic wounds, including:

[0055] Step 1. Preparation of enzyme-responsive collagen drug-loaded microspheres, including:

[0056] Step 101, adding anti-inflammatory drugs into the collagen solution, stirring at 37°C for 0.5 h to obtain a suspension containing anti-inflammatory drugs; the mass of the anti-inflammatory drugs is 0.8 times the mass of collagen, and the collagen The protein solution is a 15% collagen solution formed by dissolving collagen in water at a temperature of 37° C.; the collagen is pigskin collagen, and the anti-inflammatory drug is a hydrophobic anti-inflammatory drug. The hydrophobic anti-inflammatory drug is celecoxib; the collagen can also be one or more of other natural collagens, recombinant collagens and recombinant collagens mixed with natural collagens;

[0057] Step 102. Stir and mix 30 mL of liquid paraffin and 0.5 mL of em...

Embodiment 2

[0093] This embodiment provides a method for preparing a glucose and enzyme dual-response dressing for treating diabetic chronic wounds, including:

[0094] Step 1. Preparation of enzyme-responsive collagen drug-loaded microspheres, including:

[0095] Step 101, adding anti-inflammatory drugs into the collagen solution, stirring at 37°C for 2 hours to obtain a suspension containing anti-inflammatory drugs; the mass of the anti-inflammatory drugs is 0.2 times the mass of collagen, and the collagen The solution is a 10% collagen solution formed by dissolving collagen in water at a temperature of 37° C.; the collagen is pigskin collagen, and the anti-inflammatory drug is a hydrophobic anti-inflammatory drug. The hydrophobic anti-inflammatory drug is celecoxib; the collagen can also be one or more of other natural collagen, recombinant collagen and recombinant collagen mixed with natural collagen;

[0096] Step 102. Stir and mix 30 mL of liquid paraffin and 0.8 mL of emulsifier a...

Embodiment 3

[0112] This embodiment provides a method for preparing a glucose and enzyme dual-response dressing for treating diabetic chronic wounds, including:

[0113] Step 1. Preparation of enzyme-responsive collagen drug-loaded microspheres, including:

[0114] Step 101, adding anti-inflammatory drugs into the collagen solution, stirring at 37°C for 3 hours to obtain a suspension containing anti-inflammatory drugs; the mass of the anti-inflammatory drugs is 0.8 times the mass of collagen, and the collagen The solution is a 20% collagen solution formed by dissolving collagen in water at a temperature of 37° C.; the collagen is pigskin collagen, and the anti-inflammatory drug is a hydrophobic anti-inflammatory drug. The hydrophobic anti-inflammatory drug is celecoxib; the collagen can also be one or more of other natural collagen, recombinant collagen and recombinant collagen mixed with natural collagen;

[0115] Step 102. Stir and mix 30 mL of liquid paraffin and 0.6 mL of emulsifier a...

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Abstract

The invention discloses a glucose and enzyme double-response dressing for treating diabetic chronic wounds and a preparation method thereof, and the method comprises the following steps: adding an anti-inflammatory drug into a collagen solution to form a suspension containing the anti-inflammatory drug, mixing the suspension containing the anti-inflammatory drug with a system containing an emulsifier to form an emulsion system containing the anti-inflammatory drug, freezing the anti-inflammatory drug emulsion system, and mixing the anti-inflammatory drug emulsion system with a glutaraldehyde solution for reaction to obtain enzyme response collagen drug-loaded microspheres; mixing and reacting a system containing the enzyme response collagen drug-loaded microspheres, insulin and modified chitosan with a polyvinyl alcohol solution to obtain the glucose and enzyme double-response dressing for treating the chronic wound surface of the diabetes mellitus. The dressing prepared by the method disclosed by the invention has the characteristic of double response of glucose and matrix metalloproteinase-9, can effectively absorb tissue seepage and keep a wound moist, can perform intelligent drug delivery according to the characteristic that a diabetic foot ulcer wound has high glucose and MMP-9, and solves the two prominent problems of the wound; and the wound healing is accurately and efficiently promoted.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a glucose and enzyme dual-response dressing for treating diabetic chronic wounds and a preparation method. Background technique [0002] Diabetes is a common chronic disease, and its incidence has been increasing in recent years. Diabetic foot ulcer is a serious complication of diabetic patients. It is mainly due to the low immunity of diabetic patients. The feet far away from the heart are prone to neurological and vascular diseases due to insufficient blood supply. Ordinary foot trauma often evolves into chronic and difficult-to-heal diabetic foot ulcers. Ulcers, the treatment of patients with diabetic foot ulcers often requires high costs, and severe cases even lead to amputation. Many studies have proved that it can keep the wound surface moist, and hydrogel dressings that absorb tissue exudate can better promote wound healing. However, although comm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0066A61L26/0033A61L26/008A61L2300/43A61L2300/41A61L2300/412A61L2400/06A61L2300/622C08L5/08C08L29/04C08L89/00
Inventor 朱晨辉范代娣周宛仪傅容湛
Owner NORTHWEST UNIV(CN)
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