Liquid wound dressing and preparation method thereof

A wound and liquid technology, which is applied in the field of medicine, can solve the problems of dressings with peculiar smell, exudate leakage, and difficult patient acceptance, and achieve the effects of improving adhesion, promoting wound regeneration, and inhibiting growth and reproduction

Inactive Publication Date: 2013-12-25
重庆华昶生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantage is that when it is applied to a wound with a lot of exudate, it needs to change the dressing frequently, otherwise the exudate will leak out
In addition, the dressing itself smelled bad and had a pus-like appearance, making it difficult for patients to accept

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Weigh 1g of chitosan, add 10ml of 2% acetic acid solution, stir to dissolve, and obtain solution I;

[0033] (2) Weigh 12g of polyvinyl alcohol solid, add 30ml of deionized water, heat to 60°C, stir and dissolve to prepare solution II;

[0034] (3) Mix solution I and solution II, add 2g polyethylene glycol 400, mix well, then add 1.5g glycerin, stir and mix well;

[0035](4) Add ethanol to the solution prepared above, dilute to 100ml, mix well, use C o 60 After 30 minutes of irradiation sterilization, the liquid wound dressing of the present invention is obtained.

[0036] According to the method described in the document "Establishment of Wound Repair Animal Model" [Yang Rui, Li Yajie. Nursing Research, 2003, 17 (12A): 1369-1370], SD rats were used as experimental animals to establish a skin linear cut wound model, With "Wound Yimide" wound liquid adhesive dressing (Tianjin Yimide Medical Supplies Co., Ltd., production batch: January 2013) as the positive contro...

Embodiment 2

[0038] (1) Weigh 2g of chitosan, add 10ml of 2% acetic acid solution, stir to dissolve, and obtain solution I;

[0039] (2) Weigh 15g of polyvinyl alcohol solid, add 40ml of deionized water, heat to 60°C, stir and dissolve to prepare solution II;

[0040] (3) Mix solution I and solution II, add 1g polyethylene glycol 400, mix evenly, then add 2.8g glycerin, stir and mix evenly;

[0041] (4) Add ethanol to the solution prepared above, dilute to 100ml, mix well, use C o 60 After 30 minutes of irradiation sterilization, the liquid wound dressing of the present invention is prepared.

[0042] According to the method described in the document "Establishment of Wound Repair Animal Model" [Yang Rui, Li Yajie. Nursing Research, 2003, 17 (12A): 1369-1370], SD rats were used as experimental animals to establish a skin linear cut wound model, With "Wound Yimide" wound liquid adhesive dressing (Tianjin Yimide Medical Supplies Co., Ltd., production batch: January 2013) as the positive c...

Embodiment 3

[0044] (1) Weigh 2g of carbomer, add 20ml of ethanol, stir to dissolve, and obtain solution I;

[0045] (2) Weigh 10g of polyvinyl butyral solid, add 30ml of ethanol, stir to dissolve, and obtain solution II;

[0046] (3) Mix solution I and solution II, add 1g polyethylene glycol, then add 1.8g glycerin, stir and mix well;

[0047] (4) Add ethanol to the solution prepared above, dilute to 100ml, mix well, use C o 60 After 30 minutes of irradiation sterilization, the liquid wound dressing of the present invention is prepared.

[0048] Experiments were carried out according to the animal experiment method described in Example 1, and the results were: the positive control film forming time was 3-5min, and the experimental film forming time was 3-5min; all animals had no death, and the negative control wound healing rate was 33%, and the positive control wound healing rate was 33%. The wound healing rate of the control group was 83%, and that of the experimental group was 75%. ...

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PUM

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Abstract

The invention discloses a liquid wound dressing which is characterized by comprising the following raw materials in parts by weight: 100-180 parts of a medical polymer film forming material, 0-20 parts of chitosan, 10-25 parts of polyethylene glycol 400 and 10-28 parts of glycerin, wherein the medical polymer film forming material is one in polyvinyl alcohol and polyvinyl butyral or a mixture of carbomer and one in the polyvinyl alcohol and the polyvinyl butyral. The liquid wound dressing can absorb the wound exudate, can effectively debride, maintains the surface of a wound to be wet, promotes the wound healing and is good in sterilizing effect.

Description

technical field [0001] The invention relates to a liquid wound dressing and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] The skin is the largest organ of the human body and one of the most important organs. It has important functions such as resisting the invasion of external microorganisms, excreting and preventing water evaporation, regulating body temperature, and maintaining the stability of the internal environment of the body. At the same time, the skin is also the most important organ of the human body that is most susceptible to trauma caused by various factors. The survey shows that small-scale skin trauma such as knife wounds, burns, and bumps in daily life has become one of the most important factors that endanger the health of Chinese people. Among the 12,000 respondents, 78.7% said that they had Suffered this kind of skin trauma, among them, 45.9% of the injured left scars. Wounds caused by skin trau...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/26A61L15/24A61L15/44
Inventor 李康何红秋
Owner 重庆华昶生物技术有限公司
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