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Chitosan-silicone dressing as well as preparation method and application thereof

A technology of chitosan and silicone, which is applied in the direction of medical formulations, active ingredients of silicon compounds, medical preparations of non-active ingredients, etc., can solve problems such as unsatisfactory treatment effects, achieve reasonable formulations, promote wound healing, and prepare convenient effect

Active Publication Date: 2013-07-10
潘银根
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Clinically, in order to inhibit various hypertrophic scars caused by burns, trauma, surgery, infection, etc. and protect various wounds caused by burns, trauma, surgery, infection, etc., control wound infection, keep the wound moist, and promote wound healing. A variety of different treatment methods and products are often used, but the existing methods and products are often unsatisfactory in terms of treatment effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A chitosan silicone dressing consists of the following ingredients in percentage by weight:

[0028] Chitosan 0.1%~5% (eg 0.1%, 3%, 5%)

[0029] Silicone 1~50% (eg 1%, 25%, 50%)

[0030] Silicone antibacterial agent 0.5~5% (eg 0.5%, 3%, 5%)

[0031] Matrix balance.

[0032] The molecular weight of the silicone is 200-10000, which is methyl silicone oil (or ethyl silicone oil or phenyl silicone oil or methyl hydrogen silicone oil or methyl phenyl silicone oil).

[0033] The organosilicon antibacterial agent is organosilicon guanidine salt (or organosilicon quaternary ammonium salt or flusilazole).

[0034] The dosage form of the dressing is an aerosol, and its matrix is ​​composed of ether (or petroleum ether) and Freon (or 134a); in the matrix components, the mass percentage of ether (or petroleum ether) is 20-80%, and Freon (or 134a ) The mass percentage is 20~80%.

[0035] During preparation: mix chitosan, silicone and organic silicon antibacterial agent, dissolv...

Embodiment 2

[0038] The dosage form of the dressing is a gel, and its matrix component is a mixture of 2 to 3 components of polyvinyl alcohol, hydroxyethyl cellulose, and hydroxymethyl cellulose.

[0039] When preparing:

[0040] Mix chitosan, silicone and silicone antibacterial agent, dissolve in a matrix made of 2~3 ingredients of polyvinyl alcohol, hydroxyethyl cellulose, and hydroxymethyl cellulose, and fill in In the plastic tube, after irradiation sterilization, it is the finished product. When in use, apply to the surface of scars and wounds.

[0041] All the other are with embodiment 1.

Embodiment 3

[0043] The dosage form of the dressing is a cream, and its base composition is composed of the following components by weight:

[0044] Glyceryl monostearate 30~60 parts (eg 30 parts, 45 parts, 60 parts)

[0045] 80~120 parts of stearic acid (e.g. 80 parts, 100 parts, 120 parts)

[0046] 40~60 parts of white petrolatum (for example, 40 parts, 50 parts, 60 parts)

[0047] 130~180 parts of liquid paraffin (eg 130 parts, 150 parts, 180 parts)

[0048] Glycerin 80~120 parts (e.g. 80 parts, 100 parts, 120 parts)

[0049] Tween-80 120~150 parts (eg 120 parts, 135 parts, 150 parts)

[0050] Purified water 350~550 parts (eg 350 parts, 450 parts, 550 parts).

[0051] During preparation: mix chitosan, silicone and organic silicon antibacterial agent, miscible in glyceryl monostearate, stearic acid, white petrolatum, liquid paraffin, glycerin, Tween-80, purified water In the matrix, filled in plastic tubes, and sterilized by radiation, it is the finished product. When in use, apply...

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PUM

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Abstract

The invention discloses chitosan-silicone dressing as well as a preparation method and application thereof. The chitosan-silicone dressing comprises chitosan, silicone, an organosilicone antibacterial agent and matrix. The chitosan silicone dressing is reasonable in formula, convenient to prepare, capable of effectively inhibiting various hyperplastic scars caused by burn injury, trauma, surgery, infection and the like and various wounds caused by protecting burn injury, trauma, surgery, inflection and the like, controlling wound infection, keeping wounds moist and promoting the heating of wounds; and the chitosan silicone dressing has the bacteria inhibition capability being higher than or equal to 99% for Staphylococcus aureus and Escherichia coli.

Description

technical field [0001] The invention relates to a medical dressing and its preparation method and application. Background technique [0002] Clinically, in order to inhibit various hypertrophic scars caused by burns, trauma, surgery, infection, etc. and protect various wounds caused by burns, trauma, surgery, infection, etc., control wound infection, keep the wound moist, and promote wound healing. Various treatment methods and products are often used, but the existing methods and products are often unsatisfactory in therapeutic effect. Contents of the invention [0003] The object of the present invention is to provide a chitosan silicone dressing with reasonable formula, convenient preparation and good therapeutic effect, as well as its preparation method and application. [0004] Technical solution of the present invention is: [0005] A kind of chitosan silicone dressing is characterized in that: it is made up of the composition of following percentage by weight: ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/26A61L15/44A61L15/42A61L15/20A61L15/24A61L15/34A61K47/36A61K47/38A61K31/695A61P31/02A61P17/02
CPCY02A50/30
Inventor 潘银根姚敏潘华倩
Owner 潘银根
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