Preparation method of chitosan gelatin-based electrostatic spinning composite hydrogel wound dressing

Abstract

The invention discloses a preparation method of a chitosan gelatin-based electrostatic spinning composite hydrogel wound dressing, belonging to the field of dressing preparation. The method comprises the following steps: preparing a spinning solution from carboxymethyl chitosan and gelatin as raw materials, and performing electrostatic spinning to obtain a fiber film dressing; and performing a crosslinking reaction with glutaraldehyde steam to obtain the dressing. The composite hydrogel prepared by the preparation method is soft, has good elasticity, can absorb a large amount of wound exudate to keep a wound wet, and also accelerates the healing and tissue repair of the wound; and moreover, fewer wastes are generated in comparison with a traditional gauze dressing, and environmental pressure is reduced.

Description

technical field [0001] The invention discloses a preparation method of a chitosan gelatin-based electrospun composite hydrogel wound dressing, which belongs to the field of dressing manufacture. Background technique [0002] Medical dressing is a kind of disposable medical care product. The used dressing is a kind of highly dangerous medical waste, which is easy to cause cross-infection and environmental pollution, and needs to be treated in a centralized manner. A large amount of dressing waste is produced in our country every year, which puts great pressure on the treatment work and environmental protection. How to reduce the amount of this dangerous medical waste has attracted people's great attention. [0003] Traditional gauze dressings cannot keep the wound moist and delay wound healing; they often stick together with the wound, and it is easy to cause wound cracking when replaced. On the one hand, it damages the new tissue, which is not conducive to wound healing; Wo...

AI Technical Summary

Problems solved by technology

[0005] The technical problem mainly solved by the present invention: aiming at the problems that current gauze dressings cannot keep the wound moistened, the wound healing is delayed, and the wound is easily cracked when replaced, the pathogens are easy to pass through, and the wound infection is caused, a mixture of chitosan and gelatin is provided A preparation method for making a hydrogel dressing as a base material. The carboxymethyl chitosan and gelatin prepared by the present invention are used as raw materials to prepare a spinning solution and carry out electrospinning to obtain a fiber membrane dressing, which is then processed with glutaraldehyde steam. The dressing obtained by cross-linking reaction, the composite hydrogel prepared by the present invention has softness and good elasticity, can absorb a large amount of wound exudate, keep the wound surface moist, and accelerate wound healing and tissue repair, and is more effective than traditional gauze dressings. Less waste, less pressure on the environment