Copper-based MOF hydrogel functionalized antibacterial film as well as preparation method and application thereof

Abstract

The invention discloses a copper-based MOF hydrogel functionalized antibacterial film as well as a preparation method and application thereof. The preparation method comprises the following steps thatfirstly, a natural polymer macromonomer is synthesized, wherein the natural polymer macromonomer is any one or more of a vinyl chitosan derivative, or vinyl chitosan derivative and methacrylic acid esterified gelatin; copper ions are loaded in cross-linked hydrogel of natural polymer-g-N-isopropylacrylamide in the form of copper-based metal organic framework nanoparticles, and the copper-based MOF hydrogel functionalized antibacterial film is prepared by virtue of nucleophilic addition reaction between active groups on the surface of a hydrogel matrix and isocyanate groups on the surface of amodified antibacterial film. According to the antibacterial film and the preparation method thereof, the temperature sensitivity and antibacterial property of the copper-based MOF functionalized hydrogel and the bacterium blocking capacity of the antibacterial film are combined, effective bonding between the antibacterial film and the functionalized hydrogel is achieved through physical and chemical effects, and the antibacterial film has relatively high physical and mechanical properties while having antibacterial and bacteriostatic effects.

Description

technical field [0001] The invention relates to a temperature-sensitive hydrogel functionalized antibacterial film, in particular to a method for preparing a temperature-sensitive hydrogel functionalized antibacterial film loaded with copper metal-organic framework (MOF) nanoparticles; it belongs to film medical dressings for regeneration and repair of skin wounds manufacturing field. Background technique [0002] As a covering for wounds, medical dressings can replace damaged skin to act as a temporary barrier during wound healing, avoid or control wound infection, and provide an environment conducive to wound healing. Traditional medical dressings are used as coverings outside the wound. Although they have a protective effect on the wound surface, they are difficult to meet the treatment needs of chronic and complex wounds in terms of blocking water, ventilation and bacterial entry. In order to provide a good wound healing environment, reduce scars, and improve user comfo...

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Problems solved by technology

[0006] In order to solve the problem of poor barrier properties of current hydrogel dressings to external bacteria, and at the same time reduce the cytotoxicity caused by antibacterial agents to the greatest extent, and optimize the preparation process, the present invention provides a copper-based MOF hydrogel that can be used for tissue regeneration and repair. Glue functionalized antibacterial film and preparation method thereof

[0007] On the basis of the Chinese invention patent CN201811534121.9, the present invention introduces a polyester film layer on the surface of the temperature-sensitive hydrogel dressing. The problem of poor hydrogel strength makes dressing application more convenient; on the other hand, the polyester film is a non-porous breathable film that can isolate the entry of external bacteria while allowing the penetration of water vapor and air, thereby providing wound protection. A sterile or less bacterial healing environment, and through the synergistic effect with copper-based MOF particles, it endows the dressing with more excellent antibacterial properties, reduces the dependence of dressings on the antibacterial properties of copper-based MOF nanoparticles, and maximizes the effectiveness of dressings. Biocompatibility

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