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Extracellular matrix-imitated hydrogel dressing for diabetic foot ulcer and preparation method

A technology for diabetic foot ulcers and extramatrix, applied in pharmaceutical formulations, medical science, bandages, etc., can solve the problem of no diabetic foot ulcers, avoid toxicity and side effects, keep the wound moist, and improve the wound healing rate.

Active Publication Date: 2021-10-29
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no wound dressing for diabetic foot ulcers on the market. Based on the characteristics of impaired angiogenesis and long-term chronic inflammation of diabetic foot ulcers, a topical dressing that can significantly promote the healing of diabetic foot ulcers is designed for patients with diabetic foot ulcers. Dressings have important clinical significance and application prospects

Method used

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  • Extracellular matrix-imitated hydrogel dressing for diabetic foot ulcer and preparation method
  • Extracellular matrix-imitated hydrogel dressing for diabetic foot ulcer and preparation method
  • Extracellular matrix-imitated hydrogel dressing for diabetic foot ulcer and preparation method

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Experimental program
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Effect test

Embodiment 1

[0051] This embodiment provides a method for preparing an extracellular matrix-like hydrogel dressing for diabetic foot ulcers, including:

[0052] Step 1, preparing polydopamine nanoparticles (M@D) loaded with deferoxamine mesylate, specifically including:

[0053] Step 101, dissolving 0.36 g of surfactant Pluronic F-127 and 417 μL of 1,3,5-trimethylbenzene (TMB) in 64 mL of deionized water, then adding 60 mL of absolute ethanol, stirring to mix evenly, to obtain a TMB solution; The stirring time can be 30min;

[0054] Step 102, adding 60 mg of dopamine hydrochloride and 90 mg of tris (hydroxymethyl) aminomethane (Tris) into the TMB solution described in step 101, stirred and reacted for 24 hours at room temperature, centrifuged, washed, and freeze-dried to obtain polydopamine nanoparticles (MPDA ); said cleaning is cleaning with a volume ratio of absolute ethanol and acetone mixed solution of 2:1, and the number of times of said cleaning is 3 times;

[0055] Step 103, addi...

Embodiment 2

[0081] This embodiment provides a method for preparing an extracellular matrix-like hydrogel dressing for diabetic foot ulcers, including:

[0082] Step 1, preparing polydopamine nanoparticles (M@D) loaded with deferoxamine mesylate, specifically including:

[0083] Step 101. Dissolve 0.38 g of surfactant Pluronic F-127 and 435 μL of 1,3,5-trimethylbenzene (TMB) in 64 mL of deionized water, then add 60 mL of absolute ethanol, stir to mix evenly, and obtain a TMB solution; The stirring time can be 30min;

[0084] Step 102, adding 65 mg of dopamine hydrochloride and 90 mg of tris(hydroxymethyl)aminomethane (Tris) into the TMB solution described in step 101, stirred and reacted for 24 hours at room temperature, centrifuged, washed, and freeze-dried to obtain polydopamine nanoparticles (MPDA ); said cleaning is cleaning with a volume ratio of absolute ethanol and acetone mixed solution of 2:1, and the number of times of said cleaning is 3 times;

[0085] Step 103, adding 100 mg ...

Embodiment 3

[0105] This embodiment provides a method for preparing an extracellular matrix-like hydrogel dressing for diabetic foot ulcers, including:

[0106] Step 1, preparing polydopamine nanoparticles (M@D) loaded with deferoxamine mesylate, specifically including:

[0107] Step 101. Dissolve 0.40 g of surfactant Pluronic F-127 and 450 μL of 1,3,5-trimethylbenzene (TMB) in 120 mL of deionized water, then add 60 mL of absolute ethanol, stir to mix evenly, and obtain a TMB solution; The stirring time can be 30min;

[0108]Step 102, adding 70 mg of dopamine hydrochloride and 90 mg of tris(hydroxymethyl)aminomethane (Tris) into the TMB solution described in step 101, stirred and reacted for 24 hours at room temperature, centrifuged, washed, and freeze-dried to obtain polydopamine nanoparticles (MPDA ); said cleaning is cleaning with a volume ratio of absolute ethanol and acetone mixed solution of 2:1, and the number of times of said cleaning is 3 times;

[0109] Step 103, adding 100 mg ...

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Abstract

The invention discloses a method for preparing an extracellular matrix-imitated hydrogel dressing for diabetic foot ulcer. The method comprises the following steps: dispersing polydopamine nanoparticles loaded with deferoxamine mesylate in a modified human-like collagen solution, then performing mixing with an epigallocatechin gallate dimer grafted hyaluronic acid solution, and adding a tyrosinase solution to obtain the extracellular matrix-imitated hydrogel dressing. By dissolving the polydopamine nanoparticles loaded with deferoxamine mesylate in the modified human-like collagen solution, performing mixing with the epigallocatechin gallate dimer grafted hyaluronic acid solution, and quickly adding the tyrosinase solution, the extracellular matrix-imitating hydrogel dressing is prepared. The problems of angiogenesis damage and long-term chronic inflammation of diabetic foot ulcer wounds are solved in a targeted manner, angiogenesis and inflammation resistance can be effectively promoted, and the wound healing rate is high.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an extracellular matrix imitating hydrogel dressing for diabetic foot ulcers and a preparation method thereof. Background technique [0002] In recent years, the prevalence of diabetes in my country has shown an obvious upward trend. As a chronic disease, diabetes and its complications have gradually affected all aspects of people's lives. Diabetic foot ulcer is one of the most serious chronic complications of diabetes and the main cause of non-traumatic amputation in diabetes, which greatly reduces the quality of life of diabetic foot patients and seriously threatens their lives. Many studies have shown that hydrogel dressings that can keep the wound moist and absorb tissue exudate can promote wound healing, but the commercially available hydrogel dressings with the above characteristics have very limited therapeutic effects on diabetic foot ulcers. The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/008A61L26/0019A61L26/0033A61L26/0023A61L26/0047A61L26/0066A61L26/0061A61L2400/12A61L2300/41A61L2300/412C08L79/02C08L5/08C08L89/00
Inventor 范代娣袁扬马晓轩
Owner NORTHWEST UNIV(CN)
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