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Asymmetrical polyurethane/nano TiO2 thin film wound dressing and preparation method thereof

A wound dressing and polyurethane technology, which is applied in the field of medical wound dressing and its preparation, can solve the problems of physiological toxicity, can not fully meet the use requirements of medical wound dressing, secondary injury of new tissue, etc., and achieve the effect of accelerating the healing rate.

Inactive Publication Date: 2014-06-11
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these additional antibiotics have good antibacterial effects, they are often physiologically toxic, which will inevitably cause secondary damage to the new tissue at the wound
It can be seen that due to structural defects, the traditional polyurethane film dressing has a large gap between its many properties and ideals, and cannot fully meet the requirements for the use of medical wound dressings.

Method used

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  • Asymmetrical polyurethane/nano TiO2 thin film wound dressing and preparation method thereof
  • Asymmetrical polyurethane/nano TiO2 thin film wound dressing and preparation method thereof
  • Asymmetrical polyurethane/nano TiO2 thin film wound dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Add 1 part of ethyl titanate dropwise to a mixed solution prepared by 0.2 parts of diethanolamine and 15 parts of methyl ethyl ketone, and stir at 30°C for 25 minutes, then add 100 parts of the obtained yellow transparent solution with a solid content of 25 wt%. MDI solvent-based polyurethane solution, and continue to oscillate with ultrasonic frequency 35KHz at 30°C for 20 minutes, defoaming for later use;

[0026] Coat the prepared mixture solution on a silicon-based release paper with a coating thickness of 150 μm, and immediately heat it at 40°C for 2 minutes to evaporate the solvent on the surface of the liquid film to form a dense skin layer, and then immerse it as a whole in a pH value 4.5 Coagulate in deionized water for 30 minutes, peel off the coagulated and formed film dressing from the release paper, then fully wash with deionized water and dry at 40°C.

Embodiment 2

[0028] Add 9 parts of n-butyl titanate dropwise to the mixed solution prepared by 10.5 parts of acetylacetone and 15 parts of N,N-dimethylformamide, and stir at 35°C for 45 minutes, then add the obtained yellow transparent solution to 200 parts of a hydrogenated MDI solvent-based polyurethane solution with a solid content of 40 wt%, and continue to vibrate with a frequency of 30KHz ultrasonic waves for 30 minutes at 35°C, and defoam for subsequent use;

[0029] The prepared mixture solution was coated on chromium complex release paper with a coating thickness of 150 μm, and immediately heated at 70°C for 10 minutes to evaporate the solvent on the surface of the liquid film to form a dense skin layer, and then immerse it as a whole in a 35wt% N, N-dimethylformamide was coagulated in deionized water with a pH value of 6.0 for 5 minutes, and the film dressing after coagulation was peeled off from the release paper, then fully washed with deionized water and dried at 70°C Just dry...

Embodiment 3

[0031] Add 6 parts of n-butyl titanate dropwise to the mixed solution prepared by 6.2 parts of triethanolamine and 5 parts of N,N-dimethylacetamide, and stir at 30°C for 60 minutes, then add the obtained yellow transparent solution to 200 parts of IPDI solvent-based polyurethane solutions with a solid content of 35wt%, and continue to vibrate with ultrasonic waves at a frequency of 45KHz for 20 minutes at 30°C, and defoam for subsequent use;

[0032] Coat the prepared mixture solution on polymethylpentene release paper with a coating thickness of 150 μm, and immediately heat it at 60°C for 8 minutes to evaporate the solvent on the surface of the liquid film to form a dense skin layer, and then immerse it as a whole Containing 25wt% N,N-dimethylacetamide, coagulate in deionized water with a pH value of 5.5 for 10 minutes, peel off the solidified and formed film dressing from the release paper, then fully wash with deionized water and place at 30°C Just dry.

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Abstract

The invention discloses an asymmetrical polyurethane / nano TiO2 thin film wound dressing, which is characterized by being composed of a dense surface layer and a porous support layer, wherein the dense surface layer is integrally shaped with the porous support layer, the dense surface layer has the thickness of 7-15 mu m, the porous support layer has the total pore volume of 4.80-5.24 cm<3> / g, and in-situ generated nano TiO2 particles are uniformly dispersed in an entire polyurethane thin film and have the particle size of 30-150 nm. The invention also discloses a preparation method of the asymmetrical polyurethane / nano TiO2 thin film wound dressing. In the technical scheme disclosed by the invention, a solvent evaporation film-forming method, a wet process phase inversion film-forming method and a nano particle in-situ generation technique are felicitously organically combined, the structure of the polyurethane thin film wound dressing is reconstructed, the defects of the existing performance of the polyurethane thin film wound dressing are compensated, the comprehensive and clinical application value of the product is greatly improved, and a new method is provided for preparation of the asymmetrical polyurethane / nano TiO2 thin film wound dressing.

Description

technical field [0001] The invention belongs to the technical field of medical wound dressing and its preparation, in particular to an asymmetric polyurethane / nano-TiO 2 Film wound dressing and method for its preparation. Background technique [0002] In the clinical treatment of burns, wounds in skin grafting areas / donor areas, surgical wounds, and various types of ulcers, bedsores, pressure sores, sinus tracts and other refractory chronic wounds, the use of wound dressings can play a role in the rapid healing of wounds. to a great boost. Modern medicine believes that an ideal medical wound dressing should at least have the following functional characteristics: (1) Moderate moisture permeability (2000-2500g / m 2. 24h), to control the evaporation rate of tissue fluid secreted by the wound, to ensure that there is neither accumulation of excess tissue fluid nor complete dehydration and scab on the wound (moist healing theory); Oxygen / carbon dioxide exchange, promoting cell ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/26A61L15/18A61F13/02C08J5/18C08J9/00C08L75/04C08K3/22
Inventor 陈意范浩军刘洁徐辉石碧
Owner SICHUAN UNIV
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