The invention relates to
tertiary amine oxidation type zwitterionic lipid, lipid nano-delivery particles and application of the
tertiary amine oxidation type zwitterionic lipid and the lipid nano-delivery particles. The invention provides
tertiary amine oxidation type zwitterionic lipid which is proper in size and special in structure. The
tertiary amine oxidation type zwitterionic lipid can deliver hydrophilic / hydrophobic organic / inorganic contents. The lipid nano-delivery particles are prepared on the basis of the
tertiary amine oxidation type zwitterionic lipid, and various contents including hydrophilic drugs, hydrophobic drugs and inorganic nano-particles can be encapsulated by regulating and controlling the ratio of the
tertiary amine oxidation type zwitterionic lipid to the lipid without the tertiary amine oxidation type group. The formed lipid nanoparticles are uniform in size, stably exist in different solutions, do not
agglomerate, have long blood circularity of up to at least 60 hours, have very high specific affinity to tumors, are gathered in the tumors in quantity, do not cause any obvious damage to main organs, and can be used for preparing the lipid nanoparticles. The
bioavailability of the content and the
cancer treatment effect are obviously improved.