Application of beta-cyclodextrin derivative compound in preparation of medicine or preparation for promoting wound healing
A wound healing and cyclodextrin technology, applied in the directions of drug combinations, antipyretics, anti-inflammatory agents, etc., can solve the problems of high price, side effects, easy degradation, etc., and achieve the effect of good biocompatibility
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Embodiment 1
[0037] Example 1 Synthesis of CD-Man7
[0038] 6-hydroxy azide substituted β-cyclodextrin (β-CD-N 3 ) synthetic route can refer to literature (Journal ofOrganic Chemistry, 1996,61:903-908). 0.5g β-CD-N 3 with 0.7g propargyl-α-D-mannopyranoside Dissolve in 2.5mL DMF solution, then add 100mg copper sulfate pentahydrate and 160mg sodium ascorbate in 2.5mL aqueous solution dropwise, and the reaction solution was stirred at 60°C for 48 hours under nitrogen protection. The reaction solution was filtered through a 0.45 μm filter membrane, dialyzed and freeze-dried, and separated by a gel column to obtain CD-Man7.
Embodiment 2
[0039] Example 2C 3 - Synthesis of CD-Man7
[0040] 0.75g β-CD-N 3 Dissolve 2.25 g of 4-dimethylaminopyridine in 18 mL of anhydrous pyridine, add 5 mL of propionic anhydride to the reaction solution, and stir at 60° C. for 48 hours under nitrogen protection. After the reaction, dialyzed and freeze-dried, separated by silica gel column to obtain C 3 -CD-N 3 . Will C 3 -CD-N 3 Instead of β-CD-N in Example 1 3 , by click chemistry with 0.7g reaction to produce C 3 -CD-Man7. For specific experimental methods, please refer to the literature (Chemistry-A European Journal, 2016, 22:15216-15221).
Embodiment 3
[0041] Example 3C 2 - Synthesis of CD-Man7
[0042] With acetic anhydride instead of propionic anhydride in Example 2, after performing the same operation, an amphiphilic β-cyclodextrin compound (C 2 -CD-Man7).
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