Application of beta-cyclodextrin derivative compound in preparation of medicine or preparation for promoting wound healing

A wound healing and cyclodextrin technology, applied in the directions of drug combinations, antipyretics, anti-inflammatory agents, etc., can solve the problems of high price, side effects, easy degradation, etc., and achieve the effect of good biocompatibility

Active Publication Date: 2021-07-02
ZHEJIANG SCI-TECH UNIV
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In general, the cytokines interleukin 4 (IL-4) and interleukin 13 (IL-13) are required to induce M2 polarization of macrophages, however...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of beta-cyclodextrin derivative compound in preparation of medicine or preparation for promoting wound healing
  • Application of beta-cyclodextrin derivative compound in preparation of medicine or preparation for promoting wound healing
  • Application of beta-cyclodextrin derivative compound in preparation of medicine or preparation for promoting wound healing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Synthesis of CD-Man7

[0038] 6-hydroxy azide substituted β-cyclodextrin (β-CD-N 3 ) synthetic route can refer to literature (Journal ofOrganic Chemistry, 1996,61:903-908). 0.5g β-CD-N 3 with 0.7g propargyl-α-D-mannopyranoside Dissolve in 2.5mL DMF solution, then add 100mg copper sulfate pentahydrate and 160mg sodium ascorbate in 2.5mL aqueous solution dropwise, and the reaction solution was stirred at 60°C for 48 hours under nitrogen protection. The reaction solution was filtered through a 0.45 μm filter membrane, dialyzed and freeze-dried, and separated by a gel column to obtain CD-Man7.

Embodiment 2

[0039] Example 2C 3 - Synthesis of CD-Man7

[0040] 0.75g β-CD-N 3 Dissolve 2.25 g of 4-dimethylaminopyridine in 18 mL of anhydrous pyridine, add 5 mL of propionic anhydride to the reaction solution, and stir at 60° C. for 48 hours under nitrogen protection. After the reaction, dialyzed and freeze-dried, separated by silica gel column to obtain C 3 -CD-N 3 . Will C 3 -CD-N 3 Instead of β-CD-N in Example 1 3 , by click chemistry with 0.7g reaction to produce C 3 -CD-Man7. For specific experimental methods, please refer to the literature (Chemistry-A European Journal, 2016, 22:15216-15221).

Embodiment 3

[0041] Example 3C 2 - Synthesis of CD-Man7

[0042] With acetic anhydride instead of propionic anhydride in Example 2, after performing the same operation, an amphiphilic β-cyclodextrin compound (C 2 -CD-Man7).

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to application of a beta-cyclodextrin derivative compound in preparation of a medicine or a preparation for promoting wound healing. Beta-cyclodextrin rich in source is used as a raw material, a plurality of sugar ligand molecules are introduced into a primary hydroxyl surface of the beta-cyclodextrin; an aliphatic chain can be introduced into a secondary hydroxyl surface of the beta-cyclodextrin to serve as a hydrophobic part; the beta-cyclodextrin molecules are modified through mannose coupling, and a mannose modified beta-cyclodextrin compound with the sugar ligand multivalent effect and the sugar nanoparticles are prepared. The mannose modified beta-cyclodextrin compound can stimulate the polarization of macrophages at a wound part into M2 type, thereby promoting tissue repair and wound healing. The mannose modified beta-cyclodextrin compound not only has low toxicity, but also has the functions of promoting tissue repair and wound healing, and can be applied as a medicine or medicament.

Description

technical field [0001] The invention relates to the application of a beta-cyclodextrin derivative compound in the preparation of a medicine or preparation for promoting wound healing, belonging to the field of medicine and pharmacy. Background technique [0002] Wound healing has always been an issue of great concern in the fields of healthcare and clinical medicine, which brings huge human, material and financial burdens to people every year (Physiological Reviews, 2019, 99(1):665-706). Drugs currently used in wound healing, such as growth factor gel, can accelerate the healing of wound sites by promoting cell proliferation, skin and blood vessel regeneration, etc. However, growth factors are expensive and difficult to store, which limits their large-scale use. Yunnan Baiyao powder has the effects of removing blood stasis and stopping bleeding, promoting blood circulation and relieving pain, detoxifying and reducing swelling, but it has no obvious effect of promoting wound...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/724A61P17/02A61P29/00C08B37/16
CPCA61K31/724A61P17/02A61P29/00C08B37/0012
Inventor 张权孔祥东张远宁赵瑞波罗丹丹
Owner ZHEJIANG SCI-TECH UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap