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Preparation method of retinoic acid dressing for promoting wound healing

A technology of wound healing and retinoic acid, applied in medical science, bandages, absorbent pads, etc., can solve the problems of no obvious promotion effect and slow wound healing

Inactive Publication Date: 2021-09-14
SHANDONG LIANGFU PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such antibacterial and anti-inflammatory agents have no obvious promotion effect on tissue and fiber proliferation, so wound healing is slow

Method used

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  • Preparation method of retinoic acid dressing for promoting wound healing
  • Preparation method of retinoic acid dressing for promoting wound healing
  • Preparation method of retinoic acid dressing for promoting wound healing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Dissolve polyvinyl alcohol in distilled water at 95°C to a concentration of 4% (v / v), stir until dissolved, and then cool to room temperature;

[0032] (2) Sodium alginate was dissolved in distilled water at 40° C. to a concentration of 4% (V / V), stirred to dissolve, and then cooled to room temperature.

[0033] (3) Mix polyvinyl alcohol solution and sodium alginate solution in a beaker according to 1:1, and stir until uniform.

[0034] (4) In a new beaker, add 8g of Tween 80, 0.5g of retinoic acid and 10g of propolis, avoid light, stir to dissolve.

[0035] (5) Add 100 ml of the mixed polyvinyl alcohol and sodium alginate solution to the beaker in step 4, and stir until uniform.

[0036] (6) Add hydrochloric acid to lower the pH to 2, then add 0.75% glutaraldehyde, and stir slowly for 30 minutes.

[0037] (7) The solution was introduced into a silicon mold, frozen at -80°C for 0.5h, and freeze-dried at -50°C for 24h to obtain a dressing in the form of foam.

Embodiment 2

[0039] (1) Dissolve polyvinyl alcohol in distilled water at 95°C to a concentration of 4% (v / v), stir until dissolved, and then cool to room temperature;

[0040] (2) Sodium alginate was dissolved in distilled water at 40° C. to a concentration of 4% (V / V), stirred to dissolve, and then cooled to room temperature.

[0041] (3) Mix polyvinyl alcohol solution and sodium alginate solution in a beaker according to 2:1, and stir until uniform.

[0042] (4) In a new beaker, add 8g of Tween 80, 0.5g of retinoic acid and 10g of propolis, avoid light, stir to dissolve.

[0043] (5) Add 100 ml of the mixed polyvinyl alcohol and sodium alginate solution to the beaker in step 4, and stir until uniform.

[0044] (6) Add hydrochloric acid to lower the pH to 2, then add 0.75% glutaraldehyde, and stir slowly for 30 minutes.

[0045] (7) The solution was introduced into a silicon mold, frozen at -80°C for 1 hour, and freeze-dried at -50°C for 24 hours to obtain a dressing in the form of foam...

Embodiment 3

[0047] (1) Dissolve polyvinyl alcohol in distilled water at 95°C to a concentration of 4% (v / v), stir until dissolved, and then cool to room temperature;

[0048] (2) Sodium alginate was dissolved in distilled water at 40° C. to a concentration of 4% (V / V), stirred to dissolve, and then cooled to room temperature.

[0049] (3) Mix polyvinyl alcohol solution and sodium alginate solution in a beaker according to 3:1, and stir until uniform.

[0050] (4) In a new beaker, add 8g of Tween 80, 0.5g of retinoic acid and 10g of propolis, avoid light, stir to dissolve.

[0051] (5) Add 100 ml of the mixed polyvinyl alcohol and sodium alginate solution to the beaker in step 4, and stir until uniform.

[0052] (6) Add hydrochloric acid to lower the pH to 2, then add 0.75% glutaraldehyde, and stir slowly for 30 minutes.

[0053] (7) The solution was introduced into a silicon mold, frozen at -80°C for 2 hours, and freeze-dried at -50°C for 24 hours to obtain a dressing in the form of foa...

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Abstract

The invention relates to the field of wound treatment, and particularly relates to a preparation method of a retinoic acid dressing for promoting wound healing. A natural antibacterial anti-inflammatory agent propolis and retinoic acid are combined for use, so that the formation of ordered collagen crosslinked fibers in a wound can be effectively promoted, and the wound healing rate is improved. The dressing is a foam-form wound dressing, can retain a large amount of liquid, can controllably release a bioactive agent, has long-term drug release, and provides long-acting antibacterial protection.

Description

technical field [0001] The invention relates to the field of wound treatment, in particular to a preparation method of a retinoic acid dressing for promoting wound healing. Background technique [0002] Wound healing is generally divided into four phases: (1) hemostasis; (2) the inflammatory phase, which mainly acts on the removal of bacteria and debris in preparation for tissue growth; (3) the proliferative phase, in which granulation tissue fills the wound bed and forms new wounds. (4) In the mature stage, collagen fibers are reorganized to restore strength and flexibility. [0003] Wound dressings provide a moist protective barrier that stops infection and contamination, and are easy to apply and replace. However, at present, there are problems such as poor biocompatibility, inability to effectively prevent wound infection, and slow wound healing, which have great limitations in application. Therefore, there is a need to develop a multifunctional biomedical dressing tha...

Claims

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Application Information

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IPC IPC(8): A61L15/42A61L15/46A61L15/44A61L15/20A61L15/40
CPCA61L15/425A61L15/46A61L15/44A61L15/20A61L15/40A61L2300/404A61L2300/41A61L2300/428A61L2300/30A61L2300/45A61L2300/602
Inventor 刘文婷史宁刘洪亮
Owner SHANDONG LIANGFU PHARM CO LTD
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