The invention discloses
emodin as an inhibitor of activated molecules p-Akt and p-mTOR of a PI3K / Akt / mTOR
signal transduction pathway and application thereof, wherein the
emodin is a purely natural
anthraquinone monomer compound extracted from rhubarb as a
Chinese traditional medicine and has multiple biologic activities such as anti-microbes, anti-
inflammation, antioxidation,
immune regulation, liver protection and the like. The invention finds that after
acute leukemia multidrug-resistance cells HL-60 / ADR,
acute promyelocytic leukemia retinoic acid drug-resistant cells MR2 as well as corresponding sensitive cells NB4 and
acute leukemia primary cells are acted by the rhubarb, key
signal activated molecules of the PI3K / Akt / mTOR
signal transduction pathway, particularly p-Akt and p-mTOR, are inhabited with specificity;
in vivo researches verify that after the
emodin is dosed, all the key activated molecules p-Akt, p-p65 and p-mTOR of the PI3K / Akt / mTOR
signal pathway in
acute leukemia nude mouse transplanted
tumor tissue protein are expressed and downwards regulated, which indicates that the emodin can be used as a novel targeting inhibitor for PI3K / Akt / mTOR
signal transduction activated molecules, particularly p-Akt and p-mTOR, and is applied to treating malignant tumors of a blood
system.