33 results about "Hydroxizinum" patented technology

The invention relates to a floating and collecting agent of bertrandite beryllium ores and application thereof. In the invention, benzohydroxamic acid is used as an organic compound collecting agent, and after benzyl is introduced to hydroximic acid, the selective collecting capacity to beryllium ores of hydroximic acid medicaments is improved. The floating and collecting agent is used for the flotation of the bertrandite beryllium ores, has excellent selective collecting property and is a high-efficiency floating and collecting agent for the beryllium ores.

The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

The invention discloses a beta-carboline derivative containing hydroximic acid as well as a preparation method and a medical application thereof. The product has the structure as shown in the general formula I. The compound can be combined with other antitumor drugs such as alkylating agents, antimetabolites, topoisomerase inhibitors, mitotic inhibitors and DNA intercalating agents and additionally can be combined with radiotherapy. The invention also discloses a pharmaceutical composition containing the compound with the general formula I as well as medical application thereof, particularly application of preparation of antitumor medicines, Alzheimer disease medicines and Parkinson disease medicines. The other antitumor medicines or radiotherapy can be administrated with the compound at the same time or in different times. The combination therapy can generate the synergistic effect, so that the treatment effect is improved.

The present invention provides a medicine composition or crystal composition which is provided with specific solubility characters, which includes octanedioyl aniline hydroxamic acids or its medicinal salt or hydrated compound as the active component. The invention also provides a method for preparing the crystal composition or medicine composition. The invention also provides a composition which is provided with specific particle size distribution.

The invention relates to a macromolecule of poly(N-hexyl hydroximic acid acrylamide), and preparation and application methods thereof. The macromolecule of poly(N-hexyl hydroximic acid acrylamide) has a basic unit structure shown by the formula (I). The preparation method comprises the steps: by taking polyacrylic acid macromolecules and 6-aminohexyl hydroximic acid as active ingredients, controlling the mole ratio of carboxyl to amino in the active ingredients to be 1:(1-2) at the reaction temperature of 100-160 DEG C, reacting for 1-4 hours to produce the poly(N-hexyl hydroximic acid acrylamide) macromolecule solid product with the structure shown by the formula (I). In the preparation method, no addition solvent is needed, the reaction processes are simple and convenient, the reaction time is short, the productivity and hydroximic efficiency are high, the amide group and hydroximic group of the prepared macromolecule has synergistic coordination effect to transition metal ions, so that the macromolecule can be used as aflocculant, precipitatnt, or an adsorbent of metal ions such as iron, copper, cobalt, nickel, lanthanum, cerium, yttrium, praseodymium, neodymium and the like.

The invention belongs to the technical field of medicine and discloses bexarotene hydroximic acid as well as a preparation method and application thereof. The formation of the compound is as shown in the picture and the objective compound is prepared mainly by taking 1,1,4,4,6- pentamethyl-1,2,3,4-tetrahydronaphthalene as the initial material through the steps of Friedel-Crafts acylation, Wittig reaction and condensation reaction. The method is simple in operation, convenient in post-processing and high in yield. The objective compound has good inhibitory action on various cancer cells by the multiple action mechanisms of bonding the retinoic acid X receptors and restraining the histone deacetyltransferases, and the anti-cancer activity of the bexarotene hydroximic acid is obviously better than that of bexarotene. Therefore, the bexarotene hydroximic acid can be applied to treatment of cancers.

The invention provides a preparation method of hydroxamic acid. The preparation method comprises the following steps: reacting acid anhydride with hydroxylamine under the catalysis of alkali, and acidifying after the reaction is completed, wherein the acid anhydride is C4-C12 cycloalkane fatty acid anhydride or aromatic acid anhydride. According to the preparation method, hydroximation reaction can be realized without heating, the reaction conditions are mild, side reactions are few, the purity of the obtained product is high, and the concentrate product obtained by flotation is high in recovery rate and grade. Secondly, the synthesis conversion rate of the product is high, the raw material consumption ratio is reduced, the synthesis cost is greatly reduced, the alkali consumption in the preparation process of the method is greatly reduced, the acid required in the subsequent acidification process is also reduced, the generated waste residue sodium chloride is reduced and the wastewater discharge amount is reduced by about 50% or above.

Compounds having the formulawherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of 4-phenyl-4-hydroxy-butyric acid and capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.

The invention provides a rare-earth mineral collecting agent. The rare-earth mineral collecting agent comprises, by weight, 70-90 parts of C5-9 hydroximic acid, 5-15 parts of Medialan and 5-15 parts of C11-16 alkane kerosene. The rare-earth mineral collecting agent is good in selectivity, wide in pH applied range and high in collecting capacity.

The invention discloses a hydroxamic acid-sulfonic acid multi-ligand metal complex collecting agent, and a preparation method and an application thereof. The hydroxamic acid-sulfonic acid multi-ligandmetal complex collecting agent is obtained by a coordination reaction of hydroxamic acid-sulfonic acid multi-ligand composite micelles, prepared from hydroximate and sulfonate, and metal ions. The hydroxamic acid-sulfonic acid multi-ligand metal complex collecting agent has extremely high selective collecting capacity on titaniferous minerals such as ilmenite, rutile and anatase, can achieve selective flotation separation of the titaniferous minerals and gangue minerals, and fundamentally solves the technical problem of difficult flotation separation of the titaniferous minerals and the gangue minerals.

The invention discloses an organic compound as well as a preparation method and application thereof. The organic compound has a structure as shown in a formula I in the description, wherein R is C1-C12 alkyl; and the organic compound is obtained by carrying out amino acid condensation on alkyl thioether acetic acid and methyl 6-aminoacetate hydrochloride and then carrying out hydroximation by adopting hydroxylamine and alkali. According to the invention, thioether, acylamino and hydroxamic acid groups are combined to develop an efficient hydroxamic acid organic compound, the functional groupshave a strong synergistic effect according to the structural design of the invention, and the compound can be used as an analytical reagent for metal ions and a collecting agent for mineral flotation.In addition, the preparation method disclosed by the invention is simple, mild in reaction condition and easy to operate.

The invention belongs to the field of mineral flotation, and particularly discloses a collecting agent with a carboxyl-hydroximido structure, the structural formula of the collecting agent is shown in the specification, and the invention further provides a preparation method and application of the novel collecting agent. Carboxyl, hydroxamido and acylamino are introduced into the structure of the collecting agent at the same time, the water solubility and low-temperature adaptability of the collecting agent are improved, the chelation between the collecting agent and metal ions on the surface of minerals is enhanced, and the collecting performance is improved; the method is particularly suitable for efficient flotation recovery of minerals such as manganese carbonate ore, wolframite, scheelite, zinc oxide ore, rare earth ore, cassiterite, ilmenite, bauxite, phosphorite and fluorite ore.

The invention provides a hydroximic acid derivative and application thereof, and relates to the field of biological medicine. The hydroximic acid derivative is a compound represented by formula I, or a salt thereof, or a stereoisomer thereof, or a solvate thereof, or a hydrate thereof, or a prodrug thereof. The invention provides a compound with good inhibitory activity on HDAC and PARP, and the compound has a good inhibitory effect on HDAC and PARP, can be used for preparing a PARP / HDAC double-target inhibitor, and can be used for preventing and / or treating diseases, such as tumors, ischemic diseases, diabetes mellitus, inflammatory diseases and the like, which are improved due to PARP and / or HDAC activity inhibition. Meanwhile, the compound disclosed by the invention has a synthetic lethal effect, can be used as a chemotherapy drug sensitizer and a radiotherapy sensitizer, and can be combined with other antitumor drugs for use, so that the treatment effect is improved, and the adverse reaction is relieved. In addition, the compound provided by the invention improves the compliance of patients, has more pharmacoeconomics advantages, and has a good application prospect.

The invention discloses a hydroxamic acid-alkyl sulfuric acid multi-ligand metal complex collecting agent as well as a preparation method and application thereof. The hydroxamic acid-alkyl sulfuric acid multi-ligand metal complex collecting agent is obtained by carrying out coordination reaction on hydroxamic acid-alkyl sulfuric acid multi-ligand composite micelles prepared from hydroxamic acid salt and alkyl sulfate and metal ions. The hydroxamic acid-alkyl sulfuric acid multi-ligand metal complex collecting agent has extremely high selective collecting capacity on tungsten-containing minerals; efficient flotation separation of the tungsten-containing minerals and calcium-containing gangue minerals can be achieved under the condition that no or only a small amount of calcium-containing mineral inhibitor is contained, and the technical problem that flotation separation of the tungsten-containing minerals and the calcium-containing gangue minerals is difficult is fundamentally solved.

The present invention relates to a process for the synthesis of hydroxamic acid by a continuous flow process, wherein the process comprises reacting an alkyl ester with a hydroxylamine salt in the presence of a base in a microreactor system and continuously producing hydroxamic acid.

Compounds of formula I are provided:R1 is an alkoxy or O(CH2)pX, p is an integer from 2 to 3 and X is OH, NH2, or CO2H, m is an integer from 0 to 5, n is an integer from 0 to 5, each R2 is independently selected from hydrogen, alkenyl, hydroxyalkyl, alkoxymethyl, heterocyclyl, hetereocyclylmethyl, amino, amido, hydroxamido, any of which may be optionally substituted with one or more of acyl, alkyl, alkoxy, hydroxyalkyl, or halogen, each R3 is independently selected from hydrogen, halogen, alkyl, alkenyl, carboxy, hydroxymethyl, amido, and at least one of R2 and R3 is not hydrogen.

The invention belongs to the field of medicinal chemistry, and particularly relates to 4-triazole-2-phenylaminopyrimidine derivatives of which the structures are shown in the specification. In the formula (I), R1 is methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl; r2 is hydrogen, fluorine or trifluoromethyl; x is oxygen or. Pharmacological experiments show that the compounds and pharmaceutically acceptable salts thereof have the effect of inhibiting tumor cell proliferation.

The invention discloses a beta-carboline derivative containing hydroximic acid as well as a preparation method and a medical application thereof. The product has the structure as shown in the general formula I. The compound can be combined with other antitumor drugs such as alkylating agents, antimetabolites, topoisomerase inhibitors, mitotic inhibitors and DNA intercalating agents and additionally can be combined with radiotherapy. The invention also discloses a pharmaceutical composition containing the compound with the general formula I as well as medical application thereof, particularly application of preparation of antitumor medicines, Alzheimer disease medicines and Parkinson disease medicines. The other antitumor medicines or radiotherapy can be administrated with the compound at the same time or in different times. The combination therapy can generate the synergistic effect, so that the treatment effect is improved.

The present invention provides an improved process for preparing an hydroxycarbamoyl derivative of a carboxylic acid using a hydroxylammonium salt of a carboxylic acid as a reagent.

The invention relates to a hydroximic acid sulfonic acid compound as well as a preparation method and application thereof. The hydroximic acid sulfonic acid compound has a structural formula shown as a formula (I) in the description. The hydroximic acid sulfonic acid compound provided by the invention not only has an excellent flotation effect at a low temperature, but also is low in reagent consumption, can be used as a collecting agent to realize flotation of phosphine ore, fluorite and scheelite in a low-temperature and high-calcium-magnesium environment, and has an excellent flotation effect.

The invention discloses diosgenin hydroxamic acid derivatives as well as a preparation method and application thereof. Diosgenin is used as a lead compound, a series of hydroxamic acid derivatives are prepared through corresponding chemical reactions, and the application of the derivatives in the anti-tumor aspect is also disclosed. Pharmacological experiments show that all the synthesized diosgenin hydroximic acid derivatives are subjected to in-vitro anti-proliferative activity experiments on SW620 (human colonic adenocarcinoma cells), H358 (human non-small cell lung cancer cells), HCT-116 (human colorectal adenocarcinoma cells) and Aspc-1 (human metastatic pancreatic cancer cells) by adopting a CCK8 method. Experimental results show that the anti-tumor activity of most of the derivatives on cells is superior to that of diosgenin.

The invention discloses a 4-aminoquinazoline compound containing a morpholinyl aromatic heterocycle and a hydroximic acid structure and a preparation method of the 4-aminoquinazoline compound, and particularly discloses a 4-aminoquinazoline compound containing a morpholinyl aromatic heterocycle and a hydroximic acid structure and a preparation method of the 4-aminoquinazoline compound containing a morpholinyl aromatic heterocycle and a hydroximic acid structure. 2, 6-diamine is amidated with dicarboxylic acid monomethyl ester and subjected to a substitution reaction with hydroxylamine to obtain the 4-aminoquinazoline compound (formula 1) containing morpholinyl heteroaromatic rings and hydroximic acid structures and having various structures, X, Y and Z are independently N or CH, R is H, Cl, OCH3 or 4-morpholinyl, and L is (CH2) 2, (CH2) 3, (CH2) 4, o-C6H4, p-C6H4 or (CH2) 6. The method is mild in reaction condition, high in target product yield, safe, simple and convenient to operate, free of toxic and harmful thionyl chloride and environment-friendly, and an efficient, simple and green method is provided for synthesizing the 4-aminoquinazoline compound containing morpholinyl aromatic heterocycle and hydroximic acid structures. The invention provides a theoretical basis and clinical application value for designing and developing novel anti-drug-resistance micromolecular multi-target antitumor drugs. Formula 1.

The invention relates to the technical field of beneficiation, in particular to a flotation method and application of o-hydroxy aromatic ketoxime serving as a collecting agent in froth flotation. The structural formula of the o-hydroxy aromatic ketoxime is shown as a formula I, a formula II or a formula III. Phenolic hydroxyl groups at the adjacent positions of ketoxime groups can participate in chelation, so that the selectivity to copper is improved, and the copper-iron selectivity similar to that of an extracting agent is achieved; alkyl at the meta-position of ketoxime can provide proper lipophilicity, so that the overall collecting capacity is further enhanced, meanwhile, alkyl at the meta-position has strong defoaming capacity, and the problem that foams are too thick in existing hydroximic acid flotation is solved. According to the technical scheme, the technical problem that the selectivity and collecting capacity of a hydroximic acid flotation collecting agent in the prior art cannot meet application requirements is solved, the hydroximic acid flotation collecting agent is applied to practical operation in the mineral separation field, the recovery rate of copper and the grade of copper ore can be greatly improved, remarkable economic benefits are brought, and the hydroximic acid flotation collecting agent has ideal application value.

The invention relates to the technical field of enzyme inhibitors, in particular to a hydroxamic acid derivative and its preparation method and application. The hydroxamic acid group in the hydroxamic acid derivatives provided by the present invention is chelated with the active zinc ion in the active region of the LpxC enzyme, and contains a hydrophobic side chain combined with the hydrophobic channel in the LpxC enzyme, the above two The content of the aspect ensures that the hydroxamic acid derivatives have better bactericidal activity and lower toxicity to LpxC; the present invention also provides a preparation method of the hydroxamic acid derivatives, and the preparation method has a short reaction time , high yield.

The invention provides an application method of an ester-based hydroximic acid collecting agent to mineral flotation, and belongs to the technical field of mineral flotation. The structure of the ester-based hydroximic acid collecting agent is shown in the formula I shown in the specification, wherein in the formula I, R is a C1-C17 alkane base or C2-C17 alkylene. Due to the fact that the molecule of the ester-based hydroximic acid collecting agent contains an ester base and a hydroximic acid base, more ligating atoms and more coordinating groups are obtained, through chelation and metal ions, the more stable complex compound can be formed or strong adsorption is formed on the surfaces of metal oxide minerals, and floatation recycling of rare earth ores, titanic iron ores, scheelite, wolframite, scheelite and wolframite mixture ores or tin ores ca be strengthened; compared with an existing hydroximic acid collecting agent, due to the fact that the ester base exists in the molecule, the beneficial effects of being good in biodegradability, small in poisonousness and friendly to the environment are achieved.

The invention discloses a hydroxamic acid-alkylamine multi-ligand metal complex collecting agent, and a preparation method and an application thereof. The hydroxamic acid-alkylamine multi-ligand metalcomplex collecting agent is obtained by a coordination reaction of hydroxamic acid-alkylamine multi-ligand composite micelles, prepared from hydroxamic acid salt and alkylamine, and metal ions. The hydroxamic acid-alkylamine multi-ligand metal complex collecting agent has extremely high selective collecting capacity on rare earth ores, can realize selective flotation separation of rare earth minerals such as monazite, bastnaesite and xenotime and gangue minerals by using a small amount or zero amount of a gangue mineral inhibitor, and fundamentally solves the technical problem of difficult flotation separation of rare earth and gangue minerals.