21 results about "Hydroxizinum" patented technology

The invention discloses a preparation method of a hydroxamic acid functionalized UiO-66-(COOH) 2 fiber membrane adsorbent, and belongs to the technical field of hydroxamic acid adsorbent preparation, and the preparation method comprises the following steps: S1, preparing UiO-66-(COOH) 2; s2, UiO-66-COOCH3 is prepared, and the UiO-66- S3, preparing UiO-66-HA (hyaluronic acid); s4, a PAN / UiO-66-HA membrane is prepared; the PAN / UiO-66-HA membrane prepared by the method has the characteristics that the preparation is easy, the preparation process is green and environment-friendly, gallium ions can be adsorbed from a trace gallium solution under an acidic condition, the selective adsorption rate is high, the adsorption rate is high, and the PAN / UiO-66-HA membrane is easy to recycle.

A transparent cleansing composition comprising: about 3% to about 35% by weight of an anionic surfactant; about 5% to about 15% by weight of an amphoteric surfactant; about 0.01% to about 2% by weight of a cationic polymer; about 0% to about 1.0% by weight of an inorganic salt; about 0.01% to about 10% of a hydroxamic acid or hydroxamic acid derivative; and an aqueous carrier, wherein the composition is substantially free of sulfate-based surfactants, and the composition has a T% value of greater than about 70.

The invention discloses a tetrahydroisoquinoline hydroximic acid collecting agent and a preparation method thereof. According to the collecting agent, tetrahydroisoquinoline serves as a basic framework, and various special functional groups such as a chelating group, an ether bond and a hydrogen bond donor are contained. The preparation method comprises the steps that tyrosine methyl ester and formaldehyde react in a solvent concentrated hydrochloric acid to generate a tetrahydroisoquinoline ring skeleton, then the tetrahydroisoquinoline ring skeleton and brominated hydrocarbon react in an alkaline environment to generate ether, and finally a hydroximation reaction is conducted to obtain the corresponding hydroximic acid collecting agent. The collecting agent of the type has very high chelating capacity, shows good collecting performance and selectivity in ilmenite flotation, and can effectively improve the grade and the recovery rate of ilmenite concentrate.

The invention discloses a hydroximic acid-quaternary ammonium salt ionic liquid collecting agent and a preparation method and application thereof. The structural formula of the hydroximic acid-quaternary ammonium salt ionic liquid collecting agent is as shown in the formula (I): # imgabs0 # (I). Compared with a traditional salicylhydroxamic acid collecting agent, the hydroxamic acid-quaternary ammonium salt ionic liquid collecting agent has good collecting performance and selectivity on rare earth ore, a good collecting effect can still be achieved under the condition that a foaming agent is not added, and the hydroxamic acid-quaternary ammonium salt ionic liquid collecting agent has wide application prospects.

The invention relates to a hydroxamic acid derivative and application thereof, in particular to a compound shown in the formula I and a pharmaceutically acceptable salt or prodrug thereof, and the compound shown in the formula I has good inhibitory activity on acid sphingomyelinase and has better pharmacokinetic property compared with a parent drug. # imgabs0 #

This invention discloses a 2-phenylimidazo[1,2-] α This paper describes pyridine compounds, their preparation methods, and applications, belonging to the field of pharmaceutical technology. These compounds use imidazo[1,2-α]pyridine as the core skeleton and are prepared via a three-step method: first, cyclization of 2-aminopyridine with hydroxyacetophenone yields intermediate LT1-6; then, etherification with a brominated carboxylic acid ester yields LT7-48; finally, hydroxylamine hydrolysis converts them into the target product HDDI1-42, which contains an isohydroxamic acid group. Activity tests show that these compounds possess significant HDAC1 inhibitory activity and anti-tumor cell proliferation activity.

The invention discloses a hydroxamic acid flotation collecting agent and a synthesis method and application thereof, the application is that an amino hydroxamic acid compound is used as a mineral flotation collecting agent to be applied to flotation recovery of valuable metals in non-ferrous metals and precious metal minerals containing rare earth, cassiterite, copper oxide and the like, and two functional groups are connected through an amino group and a hydrocarbon chain; the repulsive force between coordination groups and the repulsive force between surrounding hydration layers are weakened, the hydrophobicity of the mineral surface is effectively improved, and the mineral flotation recovery performance can be remarkably improved. Compared with a common flotation collector in the prior art, enrichment and recovery of rare earth, cassiterite, copper oxide and other nonferrous metal and precious metal minerals can be effectively improved.

The invention belongs to the technical field of chemical synthesis of medicines, and particularly relates to a preparation method of avibactam sodium. According to the method, (2S, 5R)-trans-5-hydroxypiperidine-2-formic acid is taken as a starting raw material, hydroxyl in the (2S, 5R)-trans-5-hydroxypiperidine-2-formic acid is efficiently and selectively converted into hydroximido by adopting an electrochemical method, the condition is mild, the method is environment-friendly, and the pollution problem caused by using an equivalent metal reducing agent or an oxidizing agent in a traditional chemical method is avoided; after O-benzyl oxime ether is constructed, a (2S, 5R) absolute configuration required by avibactam sodium is constructed and maintained through stereoselective reduction and efficient amination. From (2S, 5R)-trans-5-hydroxypiperidine-2-formic acid to avibactam sodium, the route design is ingenious, the steps are shorter, and a novel, simple and efficient synthesis route is provided for synthesis of avibactam sodium.

Provided are compounds of formula (1) and / or formula (2), and / or pharmaceutically acceptable salts thereof, and / or racemic mixtures, hydrates, solvates, prodrugs, enantiomers, diastereomers and tautomers thereof, belonging to the technical field of medicines. Also provided are pharmaceutical compositions containing the compounds of formula (1) and / or formula (2), and the uses of the compounds of formula (1) and / or formula (2) and / or the pharmaceutically acceptable salts thereof, and / or the racemic mixtures, hydrates, solvates, prodrugs, enantiomers, diastereomers and tautomers thereof, and / or the pharmaceutical compositions in preparing histone deacetylase inhibitors and drugs used for the treatment and / or prevention of diseases responsive to histone deacetylases.

The invention relates to use of (i) from 0.0001% to 5% by weight of litsea cubeba essential oil and (ii) a hydroxamic acid and / or its corresponding hydroxamate in a composition for providing an antimicrobial benefit. The invention also relates to a method of providing an antimicrobial benefit to a surface.

The invention belongs to the technical field of medicines, and relates to a hydroxamic acid compound containing N-benzyl-2-(5-(4-methylphenyl) pyridine-2-yl) acetamide, pharmaceutically acceptable salt, hydrate and a preparation method of the hydroxamic acid compound, and a pharmaceutical composition containing the compound. The invention also relates to application of the compound in preventing and / or treating diseases related to any one and / or two of histone deacetylase (HDACs) and c-Src kinase. The structure of the compound is shown as a general formula I in the specification. # imgabs0 #

Compounds disclosed herein have been prepared for use in the treatment of diseases, disorders or conditions treatable by activation of the stimulator of interferon genes (STING) adaptor protein, such as in the treatment or prevention of cancers.

A hydroxamic acid-metal hydroxide coordination complex and preparation and application thereof are disclosed. The hydroxamic acid-metal hydroxide coordination complex is formed by a coordination of hydroxamic acid with divalent or higher valent metal ions under an alkaline condition. The hydroxamic acid-metal hydroxide coordination complex has a strong selectivity and a strong collection ability for metal oxide minerals such as tungsten-containing minerals, ilmenite, rutile, cassiterite, and rare earth. The preparation method is simple and low in costs, and is beneficial to industrialized production.

The compounds disclosed herein are prepared for use in the treatment of a disease, disorder, or condition treatable by activation of the stimulator of interferon genes (STING) adaptor protein, for example, the treatment or prevention of cancer. [Formula 1] JPEG2026508759000428.jpg48170(I)

The invention discloses a hydroximic acid compound with a structure as shown in a formula (I) or a pharmaceutically acceptable salt or a stereoisomer of the hydroximic acid compound, and application of the hydroximic acid compound or the pharmaceutically acceptable salt or the stereoisomer. The invention provides a hydroximic acid compound, and discovers that a hydroximic acid group can be covalently bound with a lysine residue of a target protein after being oxidized through a novel efficient oxidation induction strategy, the lysine residue in the protein or polypeptide can be selectively and covalently modified, and the modification of the lysine residue has high selectivity and high efficiency; the method can be used for protein activity research, and has important significance on chemical proteomics application. # imgabs0 #

The application discloses a 2-phenylimidazo[1,2 α ]pyridine compound, a preparation method and application thereof, and belongs to the technical field of medicines. The compound has an imidazo[1,2-alpha]pyridine as a core skeleton, and is prepared through a three-step method: first, 2-amino pyridine is closed with hydroxyphenylacetophenone to obtain an intermediate LT1-6, then the intermediate LT1-6 is etherified with a bromine carboxylic acid ester to obtain LT7-48, and finally, the LT7-48 is converted into a target product HDDI1-42 containing a hydroxamic acid group through hydroxylamine solution conversion. Activity tests show that the compound has significant HDAC1 inhibitory activity and anti-tumor cell proliferation activity.

The invention provides metal chelating agents and metal complexes of these agents of use in therapeutic and diagnostic applications.

The invention discloses a hydroxamic acid small-molecule compound taking pyrazole as a mother nucleus structure, a hydrate or pharmaceutically acceptable salt thereof, and application and a preparation method thereof, the structure of the compound is shown as a formula (I) or a formula (II), and the definition of each group and substituent group is shown in the specification. The compound can be used as a broad-spectrum HDAC inhibitor, not only shows high inhibitory activity at the enzyme level, but also can inhibit proliferation of various tumor cells, and the compound, the hydrate or the pharmaceutically acceptable salt thereof and the pharmaceutical composition containing the compound can be used for preventing and / or treating various tumor diseases and the like. The compound can also be used as a histone deacetylase inhibitor for preventing and treating thioredoxin-mediated diseases and the like.

This invention belongs to the field of biopharmaceuticals and relates to an HDAC6 / JNK3 dual-targeting anti-Alzheimer's disease inhibitor, its preparation method, and its application. The chemical structure is shown in Formula I: #imgabs0#, where R is H or a halogen; and X is a linker. This invention utilizes an indazole core as the cap and hydroxamic acid as the ZBG, using linkers of varying lengths and types to synthesize a series of compounds that can act as HDAC6 / JNK3 dual-targeting inhibitors, effectively treating Alzheimer's disease.

The application provides a kind of hydroxamic acid and its synthesis method and application, the hydroxamic acid has the structure shown in formula M, the distance of two hydroxylamine groups in the structure of the hydroxamic acid is more appropriate, more easily adjust and match the distance between mineral surface metal ions, can show excellent flotation effect in mineral flotation.