9 results about "Hydroxizinum" patented technology

The invention discloses a tetrahydroisoquinoline hydroximic acid collecting agent and a preparation method thereof. According to the collecting agent, tetrahydroisoquinoline serves as a basic framework, and various special functional groups such as a chelating group, an ether bond and a hydrogen bond donor are contained. The preparation method comprises the steps that tyrosine methyl ester and formaldehyde react in a solvent concentrated hydrochloric acid to generate a tetrahydroisoquinoline ring skeleton, then the tetrahydroisoquinoline ring skeleton and brominated hydrocarbon react in an alkaline environment to generate ether, and finally a hydroximation reaction is conducted to obtain the corresponding hydroximic acid collecting agent. The collecting agent of the type has very high chelating capacity, shows good collecting performance and selectivity in ilmenite flotation, and can effectively improve the grade and the recovery rate of ilmenite concentrate.

This invention discloses a 2-phenylimidazo[1,2-] α This paper describes pyridine compounds, their preparation methods, and applications, belonging to the field of pharmaceutical technology. These compounds use imidazo[1,2-α]pyridine as the core skeleton and are prepared via a three-step method: first, cyclization of 2-aminopyridine with hydroxyacetophenone yields intermediate LT1-6; then, etherification with a brominated carboxylic acid ester yields LT7-48; finally, hydroxylamine hydrolysis converts them into the target product HDDI1-42, which contains an isohydroxamic acid group. Activity tests show that these compounds possess significant HDAC1 inhibitory activity and anti-tumor cell proliferation activity.

The invention discloses a hydroxamic acid flotation collecting agent and a synthesis method and application thereof, the application is that an amino hydroxamic acid compound is used as a mineral flotation collecting agent to be applied to flotation recovery of valuable metals in non-ferrous metals and precious metal minerals containing rare earth, cassiterite, copper oxide and the like, and two functional groups are connected through an amino group and a hydrocarbon chain; the repulsive force between coordination groups and the repulsive force between surrounding hydration layers are weakened, the hydrophobicity of the mineral surface is effectively improved, and the mineral flotation recovery performance can be remarkably improved. Compared with a common flotation collector in the prior art, enrichment and recovery of rare earth, cassiterite, copper oxide and other nonferrous metal and precious metal minerals can be effectively improved.

The invention belongs to the technical field of chemical synthesis of medicines, and particularly relates to a preparation method of avibactam sodium. According to the method, (2S, 5R)-trans-5-hydroxypiperidine-2-formic acid is taken as a starting raw material, hydroxyl in the (2S, 5R)-trans-5-hydroxypiperidine-2-formic acid is efficiently and selectively converted into hydroximido by adopting an electrochemical method, the condition is mild, the method is environment-friendly, and the pollution problem caused by using an equivalent metal reducing agent or an oxidizing agent in a traditional chemical method is avoided; after O-benzyl oxime ether is constructed, a (2S, 5R) absolute configuration required by avibactam sodium is constructed and maintained through stereoselective reduction and efficient amination. From (2S, 5R)-trans-5-hydroxypiperidine-2-formic acid to avibactam sodium, the route design is ingenious, the steps are shorter, and a novel, simple and efficient synthesis route is provided for synthesis of avibactam sodium.

Compounds disclosed herein have been prepared for use in the treatment of diseases, disorders or conditions treatable by activation of the stimulator of interferon genes (STING) adaptor protein, such as in the treatment or prevention of cancers.

The compounds disclosed herein are prepared for use in the treatment of a disease, disorder, or condition treatable by activation of the stimulator of interferon genes (STING) adaptor protein, for example, the treatment or prevention of cancer. [Formula 1] JPEG2026508759000428.jpg48170(I)

The application discloses a 2-phenylimidazo[1,2 α ]pyridine compound, a preparation method and application thereof, and belongs to the technical field of medicines. The compound has an imidazo[1,2-alpha]pyridine as a core skeleton, and is prepared through a three-step method: first, 2-amino pyridine is closed with hydroxyphenylacetophenone to obtain an intermediate LT1-6, then the intermediate LT1-6 is etherified with a bromine carboxylic acid ester to obtain LT7-48, and finally, the LT7-48 is converted into a target product HDDI1-42 containing a hydroxamic acid group through hydroxylamine solution conversion. Activity tests show that the compound has significant HDAC1 inhibitory activity and anti-tumor cell proliferation activity.

The application provides a kind of hydroxamic acid and its synthesis method and application, the hydroxamic acid has the structure shown in formula M, the distance of two hydroxylamine groups in the structure of the hydroxamic acid is more appropriate, more easily adjust and match the distance between mineral surface metal ions, can show excellent flotation effect in mineral flotation.