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Method for preparing retinoic hydroxyapatite bionic compound, and bionic compound

A technology of retinoic acid hydroxyapatite and compound, applied in the field of medical devices, can solve the problems of slow absorption, difficult to heal, high price, etc., and achieve the effects of preventing ectopic osteogenesis, large osteogenic effect, and excellent osteogenic effect.

Inactive Publication Date: 2014-07-30
柳毅 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since all-trans retinoic acid (ATRA) is a commonly used drug in clinical practice and its price is low, its clinical use can significantly reduce the cost of clinical treatment and reduce the economic burden of patients. The bone filling materials currently used in clinical practice mainly come from abroad, which are expensive and expensive. Unsatisfactory bone effect, slow absorption and difficult to heal clinically, prolonging the clinical action time
[0003] In addition, the amount of osteogenic materials currently used in clinical practice needs to be increased to compensate for the bone filling material absorbed during the osteogenesis process, which not only increases medical costs, but also causes swelling of the bone filling site, resulting in long-term postoperative swelling of the patient. Disadvantages such as unsightly appearance of the operation area

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: The preparation steps of this embodiment are as follows:

[0030] a, take 7.3 grams of hydrogen chloride (HCL), 2.58 grams of calcium chloride hydrate (CaCl 2 h 2 O), 39.78 grams of sodium chloride (NaCL), 1.42 grams of sodium monohydrogen phosphate (NaCl 2 HPO 4 ), 39.4 grams of tris buffer solution with a pH value of 7.4, add 1L of ultrapure water, adjust the pH value to 6.25, keep the temperature on a magnetic stirrer at 37 degrees, and continue stirring at a speed of 50r / min for 24 Hours, after the precipitation is generated, vacuum filter with a 0.22 micron filter, and carry out high temperature and high pressure sterilization to the solid matter obtained after the filtration;

[0031] b. Clean the material obtained in step a with ultrapure water, filter and compress it in a vacuum environment, and put it into a shaper to form a certain fixed shape (cylindrical or strip), which is convenient for drying; after vacuum drying for 2 hours , grind it w...

Embodiment 2

[0036] Embodiment 2: The preparation steps of this embodiment are as follows:

[0037] a, take 7.3 grams of hydrogen chloride (HCL), 2.58 grams of calcium chloride hydrate (CaCl 2 h 2 O), 39.78 grams of sodium chloride (NaCL), 1.42 grams of sodium monohydrogen phosphate (NaCl 2 HPO 4 ), 39.4 grams of tris buffer solution with a pH value of 7.4, add 1L of ultrapure water, adjust the pH value to 6.25, keep the temperature on a magnetic stirrer at 37 degrees, and continue stirring at a speed of 50r / min for 24 Hours, after the precipitation is generated, vacuum filter with a 0.22 micron filter, and carry out high temperature and high pressure sterilization to the solid matter obtained after the filtration;

[0038] b. Clean the material obtained in step a with ultrapure water, filter and compress it in a vacuum environment, and put it into a shaper to form a certain fixed shape (cylindrical or strip), which is convenient for drying; after vacuum drying for 2 hours , grind it w...

Embodiment 3

[0043] Embodiment 3: The preparation steps of this embodiment are as follows:

[0044] a, take 6.5 grams of hydrogen chloride (HCL), 2 grams of calcium chloride hydrate (CaCl 2 h 2 O), 38 grams of sodium chloride (NaCL), 1 gram of sodium monohydrogen phosphate (Na 2 HPO 4 ), 39 grams of tris buffer solution with a pH value of 7.4, adding 1L of ultrapure water, adjusting the pH value to 6.25, maintaining the temperature at 37 degrees on a magnetic stirrer, and continuously stirring at a speed of 50r / min for 24 Hours, after the precipitation is generated, vacuum filter with a 0.22 micron filter, and carry out high temperature and high pressure sterilization to the solid matter obtained after the filtration;

[0045] b. Clean the material obtained in step a with ultrapure water, filter and compress it in a vacuum environment, and put it into a shaper to form a certain fixed shape (cylindrical or strip), which is convenient for drying; after vacuum drying for 2 hours , grind i...

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Abstract

The invention relates to a method for preparing a retinoic hydroxyapatite bionic compound and the bionic compound. By virtue of the method for preparing the retinoic hydroxyapatite bionic compound and the retinoic hydroxyapatite bionic compound prepared by utilizing the method, a bone is formed by utilizing the bionic compound in the clinical application, the cost is low, the effect of bone formation is good, and ectopic bone formation, postoperative swelling and other complications can be effectively avoided. The technical scheme adopted by the invention is as follows: the preparation method comprises the following steps: a, preparing a core of a bionic layer; b, coating the surface of the core of the bionic layer with a functional layer; c, coating the surface of the product obtained in the step with one more functional layer. The bionic compound is mainly applied to the technical field of medical appliances.

Description

technical field [0001] The invention relates to a method for preparing a retinoic acid hydroxyapatite biomimetic compound and the retinoic acid hydroxyapatite biomimetic compound prepared by the method, which can be widely used in plastic surgery, trauma orthopedics and oral implant restoration Hydroxyapatite biomimetic material for reconstructive surgery. It belongs to the technical field of medical equipment. Background technique [0002] Bone nonunion and delayed union caused by bone defect are difficult problems in clinical treatment. Although autologous bone grafting is the gold standard for repairing bone defects, donor site complications are fatal defects that are difficult to overcome. The ideal tissue engineered bone should have: (1) good biocompatibility and biodegradable absorbability; (2) suitable three-dimensional microstructure; (3) easy processing to form three-dimensional geometry; (4) suitable surface physical and chemical properties ; (5) Certain mechani...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/12A61L27/54C01B25/32
Inventor 柳毅林振霍光谷志远
Owner 柳毅
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