The invention relates to a method for preparing a P(LLA-CL) / collagen double-layer vascular stent coordinated and regulated by heparin and gemini, comprising: mixing P(LLA-CL) and collagen in a solvent to obtain a composite spinning Silk liquid; dissolving heparin sodium and VEGF in the diluent to obtain the drug solution loaded on the inner layer; dissolving PDGF in the diluent to obtain the drug solution loaded on the outer layer; the drug solution loaded on the inner layer is the core layer, and the spinning solution is the shell The inner layer of the stent is obtained by coaxial electrospinning; the drug solution loaded on the outer layer is the core layer, and the spinning solution is the shell layer, and the outer layer of the stent is obtained by bidirectional conjugate electrospinning, which is continuously received in the inner layer of the stent On the outside, a double-layer vascular stent was obtained, cross-linked, and obtained. The vascular stent of the present invention has excellent mechanical properties and biocompatibility, can mimic the components, structures and functions of natural blood vessels, and is beneficial to the in situ regeneration of vascular tissues and the reconstruction of multilayer structures, and is of great importance in vascular tissue engineering. Applications.