The present application relates to the field of
tissue engineering and biomedical materials, in particular to a macroporous multi-scale
tissue engineering scaffold based on
electrospinning and a preparation method and application thereof; first, a PU / PLCL blended
electrospinning film is prepared, the
electrospinning film is broken into a dispersion liquid and a
gelatin solution, and the dispersion liquid and the
gelatin solution are mixed at a certain ratio, and a three-dimensional
tissue engineering scaffold is prepared by cross-linking the
gelatin; the
vascular tissue engineering scaffold has a
macropore, good mechanical properties, a suitable swelling rate and a
water contact angle, good
biocompatibility, and to some extent, the structure of nanofibers is retained; and the present application can be applied to the field of artificial
blood vessel materials and vascular
transplantation biomedical materials.