Degradable tubular polymeric multipore foaming material and its preparation method

A technology of porous foam and polymer, applied in the direction of coating, etc., can solve the problems of easy degradation of polymers and harsh conditions, and achieve the effect of good reproducibility, good shape retention ability, and large-scale production

Inactive Publication Date: 2004-07-21
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method has harsh conditions and requires high temperature (often higher than 250°C) and high pressure (often higher than 150MPa), which leads to the easy degradation of polymers and requires high-pressure equipment such as hydraulic presses.

Method used

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  • Degradable tubular polymeric multipore foaming material and its preparation method
  • Degradable tubular polymeric multipore foaming material and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1, 0.3 grams of PLGA85 / 15 with a molecular weight of 300,000 was dissolved in 3 milliliters of chloroform, and 2.7 grams of sodium chloride particles with a particle size of 180-280 μm were added to the solution, stirred evenly, and the solvent was partially volatilized, and the solvent body was adjusted. The integral rate is about 38.0%, and the particle volume fraction is about 52.0%, forming a soft doughy polymer solution-porogen particle mixture; the mixture is filled into a small injection molding machine trough (see figure 1 ), the composite mold for injection molding with a tubular inner cavity shape is installed, and the polymer solution-porogen particle mixture is quickly filled into the mold cavity under the injection pressure; after demolding, the polymer solution-porogen particle mixture is obtained. For tubular products, part of the solvent is volatilized at room temperature, and then the remaining solvent is removed at room temperature and a vacuum ...

Embodiment 2

[0047] Embodiment 2, porogen particle sodium chloride particle size is 280-450 μ m, adjust solvent volume fraction about 43.4%, particle volume fraction is about 47.5%, other is the same as embodiment 1, makes tubular porous foam porosity 86.4%.

Embodiment 3

[0048] Example 3, 0.15 grams of PLGA85 / 15 with a molecular weight of 300,000 was dissolved in 3 milliliters of chloroform, and 2.85 grams of sodium chloride particles with a particle size of 180-280 μm were added to the solution, stirred evenly, and the solvent was partially volatilized, and the volume fraction of the solvent was adjusted. The ratio is about 42.4%, and the particle volume fraction is about 48.3%, forming a soft doughy polymer solution-porogen particle mixture; others are the same as in Example 1, and the obtained tubular porous foam has a porosity of 93.6%.

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Abstract

A degradable tubular high-molecular porous foam material used as the porous cell scaffold of blood vessel tissue or nerve tissue engineering is prepared from a high-molecular material through use of combined mould. Its advantages are high porosity up to 90% and uniform distribution of pores.

Description

technical field [0001] The invention belongs to the technical fields of polymer materials and biomedical engineering, and specifically relates to a degradable tubular polymer porous foam material and a preparation method thereof. technical background [0002] Porous foam materials are widely used in many fields such as chemical industry, pharmaceutical, biomedical engineering and so on. In recent years, the rapid development of tissue engineering has put forward new requirements for new porous foam materials, and the preparation methods and technologies of polymer porous foams have become more and more important. Tubular porous foams play an important role in the fields of vascular tissue engineering and neural tissue engineering. [0003] However, there is still a lack of effective and practical methods for the preparation of tubular porous foams, especially small-diameter and thin-walled tubular porous scaffolds. [Wake, 1996] first obtained a porous membrane by solvent c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C45/00C08J9/26
Inventor 丁建东吴林波
Owner FUDAN UNIV
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