4 results about "Neural tissue engineering" patented technology

The present invention introduces an approach to neural tissue engineering by developing vascularized neurospheres (VNSs) through novel methods, systems, and kits. These VNSs are generated using a unique blend of neural, vascular, and supportive cells, cultured in specialized hydrogel-containing media. The VNSs feature an integrated vascular network, serving as a physiologically relevant in vitro model. The invention also offers a grafting technique for therapeutic applications in neural disorders and injuries, as well as facilitating brain-computer interfacing. Beyond therapeutics, the VNSs have broad applications in drug development, synthetic biology, disease modeling, and more. The invention also includes kits for VNS generation and methods for interfacing VNSs with probes for applications of brain-computer interfacing. Overall, this patent represents a significant leap in the field, bridging the gap between in vitro and in vivo systems and opening new avenues in research, therapeutics, and bioengineering.

This invention discloses a tough anisotropic hydrogel, its preparation method, and its applications, belonging to the field of biomedical polymer materials technology. The method involves preparing a prepolymer solution using polymer monomers, zirconium salts, and an initiator. After polymerization to obtain an initial hydrogel, the solution is pre-stretched and simultaneously dialyzed in deionized water to achieve equilibration, resulting in a tough anisotropic hydrogel. This method utilizes the synergistic effect of physical pre-stretching and metal coordination bond locking to guide the directional reconstruction of the hydrogel network, thus simply and efficiently preparing a tough anisotropic hydrogel with a stable orientation structure. This hydrogel possesses high strength, high modulus, and high toughness, and also has the ability to guide the directional growth of nerve cells, showing promising application prospects in neural tissue engineering, flexible electronics, and other fields.

The invention belongs to the field of biological materials and nervous tissue engineering, and provides a mimic peptide CIDPC modified magnetic directional freeze-drying scaffold as well as a preparation method and application thereof, and the mimic peptide CIDPC modified magnetic directional freeze-drying scaffold has a good directional topological structure and biocompatibility. Through the synergistic effect of an external magnetic field and the mimic peptide, proliferation, differentiation and directional migration of nerve cells can be effectively promoted, angiogenesis is promoted, in-vivo inflammation is regulated and controlled, axon regeneration and angiogenesis are stimulated, and sensory and motor neuron regeneration is stimulated, so that a remarkable effect is shown in spinal cord injury repair; and a new thought and a new method are provided for nervous tissue engineering injury repair.

The invention provides a biological scaffold with a piezoelectric effect as well as a preparation method and application of the biological scaffold. According to the invention, bismuth titanate (Bi4Ti3O12) nanosheets with excellent piezoelectric properties are compounded with poly-L-lactic acid (PLLA) with better biocompatibility through an electrostatic spinning technology for the first time, a novel bionic nervous tissue engineering scaffold is developed, the scaffold has degradability and excellent biocompatibility and safety, the flexibility of the scaffold is improved, and the scaffold can be applied to the field of biological engineering. The defects of high inherent hardness, high brittleness, non-degradability and cytotoxicity of an inorganic piezoelectric material are overcome. The PLLA / Bi4Ti3O12 composite scaffold provided by the invention can significantly promote neuronal differentiation of neural stem cells, inhibits directional differentiation of glial cell lineages while enhancing neuronal differentiation, can be used as an advanced nerve regeneration interface in nervous tissue engineering, provides a very potential strategy for neural circuit reconstruction and functional recovery, and has a wide application prospect. And a new direction is developed for neural restoration and treatment of neurodegenerative diseases.