Preparation method for polylactic acid fiber three-dimensional bionic porous ordered scaffold

A polylactic acid fiber, polylactic acid technology, which is applied in the fields of medical science, surgery, prosthesis, etc., can solve problems such as poor thermal stability, and achieve the effect of simple method and process

Active Publication Date: 2015-03-11
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method cannot be used for polymers with

Method used

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  • Preparation method for polylactic acid fiber three-dimensional bionic porous ordered scaffold
  • Preparation method for polylactic acid fiber three-dimensional bionic porous ordered scaffold
  • Preparation method for polylactic acid fiber three-dimensional bionic porous ordered scaffold

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Experimental program
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Effect test

Embodiment 1

[0052] PLA slices with a molecular weight of 170,000 were prepared by melt spinning method into PLA melt-spun fibers with an average diameter of 12.41 μm, and the aggregates arranged in parallel were wound with a skein length measuring instrument, the rotation speed was 300r / min, and the circumference of the yarn frame It is 1000mm and the width is 3.5cm. 800 PLA ​​fibers arranged in parallel were wound with an initial tension of 100cN. Fully submerge the brush in the 15% solid content polyurethane adhesive for about 2 seconds, take out the brush and lightly brush on the PLA fiber surface once, then completely immerse the brush in the 15% solid content polyurethane adhesive for about 2 seconds, Take out the brush and brush lightly on the surface of the PLA fiber once, so that the ordered fiber bundles of PLA are bonded into a whole. Curing at 40°C for 1 hour without any tension during the curing process. Naturally cooled to room temperature, the three-dimensional porous orde...

Embodiment 2

[0055] Adopt the same method and condition as embodiment 1, just change the number of PLA fibers to be 1300. The surface and cross-sectional morphology of the PLA melt-spun fiber ordered scaffold prepared in this embodiment are as follows: image 3 and 4 shown.

[0056] The prepared three-dimensional porous ordered scaffold has an average thickness of 0.0988cm and a weight of 0.05466g / cm 2 , the degree of order is 104.78°, the pore diameter is 5.90 μm, the porosity is 53.33%, and the connectivity between pores is good. Since water droplets directly enter the internal pores from the surface of the scaffold, it can be known from the contact angle test that the scaffold is hydrophilic. The water absorption rate of the scaffold was 116.22% in 1h, and 141.42% in 6h. The adsorption capacity of the scaffold to 1mg / mL gelatin solution in 10min is 0.66g / cm 3 , the adsorption capacity at 60min is 0.63g / cm 3 . The tensile stress and strain of the scaffold along the fiber alignment...

Embodiment 3

[0058] The PLA slices with a molecular weight of 200,000 were prepared into PLA melt-spun fibers with an average diameter of 12.41 μm, and a parallel assembly was wound with a skein length measuring instrument at a speed of 1 r / min. The circumference of the yarn frame was 1000 mm, and the width was 3.5cm. 1000 PLA ​​fibers arranged in parallel were wound with an initial tension of 100cN. Submerge the brush completely in 5% solid content cyanoacrylate adhesive for about 2 seconds, take out the brush and brush lightly on the PLA fiber surface once, then completely immerse the brush in 5% solid content polyurethane adhesive After about 2 seconds, take out the brush and brush lightly on the surface of the PLA fiber once, so that the ordered fiber bundles of PLA can be bonded into a whole. At 100°C, the curing time is 1.5h, and no tension is added during the curing process. Naturally cooled to room temperature, the three-dimensional porous ordered scaffold of PLA melt-spun fibers...

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Abstract

A disclosed preparation method for a polylactic acid fiber three-dimensional bionic porous ordered scaffold comprises the following steps: slicing polylactic acid (PLA) with good biodegradability and biocompatibility, and successively performing spinning and winding to prepare fiber assemblies in parallel arrangement; using a medical binder to bond the loose and parallel-arranged PLA fiber assemblies to form a stable structure; and then curing and naturally cooling to room temperature. The polylactic acid fiber three-dimensional bionic porous ordered scaffold prepared by using the method has relatively small thickness and weight, relatively large pore diameter and porosity, and relatively good order degree, pore communication property, hydrophily, hydroscopicity, mechanical properties and adsorption capability on gelatin. The ordered scaffold has relatively good application prospect, is applicable to aspects of cell vectors of blood vessel engineering and nerve tissue engineering, ligament base materials, medicine loading and release, nerve regeneration of nerve tissue engineering, implantation type functional muscle, restoration of knee damage and bone arthritis, bone tissue engineering, and the like.

Description

technical field [0001] The invention relates to a preparation method of a polylactic acid fiber three-dimensional bionic porous ordered support. Background technique [0002] When designing a three-dimensional bionic scaffold, the pore structure of the scaffold is a key parameter. The existing tissue engineering technology is to culture cells on three-dimensional biomimetic scaffolds made of biomaterials, which must have good biodegradability, biocompatibility, specific physical and mechanical properties, and chemical stability (Karande TS, Ong JL, Agrawal CM. Diffusion in musculoskeletal tissue engineering scaffolds: Design issues related to porosity, permeability, architecture, and nutrient mixing. Ann Biomed Eng. 2004; 32:1728-43.). Among them, oxygen and nutrient transport, waste removal, protein transport, and cell migration are all related to the porosity of the scaffold (Yang J, Shi GX, Bei JZ, Wang SG, Cao YL, Shang QX, et al. surface modification of macroporous po...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/56A61L27/54A61L31/06A61L31/16
Inventor 高长有冯建永
Owner ZHEJIANG UNIV
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