Retina cell scaffold biological surgical binder and preparing method thereof

A retinal cell and adhesive technology, applied in the field of retinal cell scaffold biosurgical adhesive and its preparation, can solve the problems of poor retinal integration and the like
CN105597145AInactive Publication Date: 2016-05-25ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
Publication Date
2016-05-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a retina cell scaffold biological surgical binder and a preparing method thereof. The retina cell scaffold biological surgical binder comprises laminin, type-IV collagen, nidogen, human heparin sulphate protoglycans, fibroblast growth factors, matrix metalloproteinase and phosphate buffer salt solution. By the adoption of the retina cell scaffold biological surgical binder, degradable human iPSCs-derived retina nerve scaffold (iRMP) can be bound with a host retina nerve layer, and effective integration of a cell biological scaffold and a host retina is guaranteed. The tissue engineering technology and clinical practice are combined, and the retina cell scaffold biological surgical binder has certain theoretical and practical application value for regenerative medicine fundamental research and ophthalmology clinical treatment, promotes optic nerve system damage repair and nervous tissue engineering research, and lays a theoretical and experimental foundation for tissue engineering transplantation therapy of visual damage.
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Description

Technical field:

[0001] The invention belongs to the field of tissue engineering, and in particular relates to a retinal cell scaffold biooperative adhesive and a preparation method thereof. Background technique:

[0002] The damage and repair of retinal neurons is a common scientific problem in the occurrence, development and outcome of neurological visual damage. In recent years, with the rapid development of stem cell research, induced pluripotent stem cells (iPSCs) have brought new hope for the repair and treatment of optic nerve damage. Due to the self-replication and multi-differentiation potential of iPSCs, as a donor for repairing nervous system damage, it can not only meet the cell quantity required for transplantation, but also iPSCs can be induced to differentiate into different neural cell lines including neurons under certain conditions. Therefore, the use of human-derived iPSCs transplantation to treat optic nerve injury diseases has important theoretical sign...

Claims

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