Preparation method of PCL (polycaprolactone)/CNTs (carbon nanotubes) compound electrospun film

A technology of electrospinning and mixed solution, applied in the field of materials science, to improve repair efficiency, promote neuronal differentiation, and enhance electrical activity

Inactive Publication Date: 2019-09-10
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As mentioned above, various techniques have been employed to achieve electrospun fibers with different degrees of orientation, but relatively few studies have systematically revealed the specific relationship between fiber alignment, physical properties, and biological properties.

Method used

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  • Preparation method of PCL (polycaprolactone)/CNTs (carbon nanotubes) compound electrospun film
  • Preparation method of PCL (polycaprolactone)/CNTs (carbon nanotubes) compound electrospun film
  • Preparation method of PCL (polycaprolactone)/CNTs (carbon nanotubes) compound electrospun film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Weigh a certain amount of polycaprolactone (PCL) and dissolve it in chloroform, stir for 24 h until the solution is uniform and transparent, and the concentration of PCL is 10 wt.%;

[0042] (2) In order to prepare PCL / CNTs composite electrospun fibers, a certain concentration of CNTs was added to the polymer solution (10wt.%), and the CNTs were kept in a good dispersion state by continuous ultrasonication for 30 minutes;

[0043] (3) Inhale PCL or PCL / CNTs solution into a 10 mL plastic syringe, press 0.10 mm·min –1 Launched, the high-voltage power supply applied an electric field of 15 kV during the spinning process;

[0044] (4) The obtained PCL or PCL / CNTs electrospun was collected on a metal cylindrical roller 14 cm away from the needle tip (D=16 cm, L=22 cm);

[0045] (5) In order to obtain oriented fibers, set the rotation speed of the drum collection device to 1000 rpm, and control the thickness of the final electrospun fiber membrane to 150 μm;

[0046] (6...

Embodiment 2

[0048] (1) Weigh a certain amount of polycaprolactone (PCL) and dissolve it in chloroform, stir for 24 h until the solution is uniform and transparent, and the concentration of PCL is 12 wt.%;

[0049] (2) In order to prepare PCL / CNTs composite electrospun fibers, a certain concentration of CNTs was added to the polymer solution (10wt.%), and the CNTs were kept in a good dispersion state by continuous ultrasonication for 30 minutes;

[0050] (3) Inhale PCL or PCL / CNTs solution into a 10 mL plastic syringe, press 0.10 mm·min –1 Launched, the high-voltage power supply applied an electric field of 15 kV during the spinning process;

[0051] (4) The obtained PCL or PCL / CNTs electrospun was collected on a metal cylindrical roller 14 cm away from the needle tip (D=16 cm, L=22 cm);

[0052] (5) In order to obtain oriented fibers, set the rotation speed of the drum collection device to 1000 rpm, and control the thickness of the final electrospun fiber membrane to 160 μm;

[0053] (6...

Embodiment 3

[0055] (1) Weigh a certain amount of polycaprolactone (PCL) and dissolve it in chloroform, stir for 24 h until the solution is uniform and transparent, and the concentration of PCL is 10 wt.%;

[0056] (2) In order to prepare PCL / CNTs composite electrospun fibers, a certain concentration of CNTs was added to the polymer solution (15wt.%), and the CNTs were kept in a good dispersion state by continuous ultrasonication for 30 minutes;

[0057] (3) Inhale PCL or PCL / CNTs solution into a 10 mL plastic syringe, press 0.10 mm·min –1 Launched, the high-voltage power supply applied an electric field of 15 kV during the spinning process;

[0058] (4) The obtained PCL or PCL / CNTs electrospun was collected on a metal cylindrical roller 14 cm away from the needle tip (D=16 cm, L=22 cm);

[0059] (5) In order to obtain oriented fibers, set the rotation speed of the drum collection device to 1000 rpm, and control the thickness of the final electrospun fiber membrane to 165 μm;

[0060] (6...

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Abstract

The invention discloses a PCL (polycaprolactone)/CNTs (carbon nanotubes) compound electrospun film with optimal fiber orientation for inducing nerve regeneration. The PCL/CNTs compound electrospun film has the characteristics of large specific surface area and high porosity, is very similar to an extracellular matrix, and can be used as a support for supporting regeneration of various cells into complete tissues. The introduction of CNTs can further enhance the electrical activity of the composite support, so that the repair efficiency of nervous tissues is further improved under the action ofelectrical stimulation. The obtained PCL/CNTs compound electrospun film with the optimal fiber orientation lays a solid theoretical foundation for nerve defect repair in nervous tissue engineering, the process is simple, convenient, and easy to operate, and popularization and application are facilitated.

Description

technical field [0001] The invention belongs to the technical field of materials science, and in particular relates to a PCL / CNTs composite electrospinning membrane with optimal fiber orientation for inducing nerve regeneration. Background technique [0002] Electrospinning is a special fiber nano-manufacturing technology, which uses the force of an electric field to stretch the polymer solution to form ultra-fine fibers. The electrospun nanofiber membrane prepared by it has the characteristics of large specific surface area and high porosity, which is very similar to extracellular matrix (ECM), and is often used as a scaffold to support the regeneration of various cells into complete tissues. Poly(ε-caprolactone) (PCL) is an environmentally friendly biodegradable polymer material with good biocompatibility. Because it is non-toxic and harmless and easy to make, it is favored by a large number of tissue engineering researchers and has broad application prospects. At presen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/4382D04H1/728D04H1/435D01D5/00D01D1/02A61L27/50A61L27/44
CPCA61L27/443A61L27/50A61L2400/12A61L2430/32D01D1/02D01D5/003D01D5/0076D01D5/0092D04H1/435D04H1/4382D04H1/728C08L67/04
Inventor 张进乔紫雯王君曾亮丹刘晓晨
Owner FUZHOU UNIV
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