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Supramolecular hydrogel as well as preparation method and application thereof

A technology of supramolecular hydrogel and gelatin, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of electrical conductivity, self-healing performance, poor plasticity, and limited application

Active Publication Date: 2021-07-06
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, due to the shortcomings of such materials, such as electrical conductivity, self-healing performance and poor plasticity, they are rarely used in nerve injury repair, which limits their application.

Method used

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  • Supramolecular hydrogel as well as preparation method and application thereof
  • Supramolecular hydrogel as well as preparation method and application thereof
  • Supramolecular hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Mix 2mL of gelatin solution with 100μL of pyrrole (99wt%, AR), and then add ammonium persulfate solution, wherein the molar ratio of ammonium persulfate to pyrrole is 1:1, place the mixed solution at 4°C for 12h and then add 1mL The tannic acid solution was shaken at 37°C for 5s to cross-link to obtain the product.

[0037] Scanning electron microscope (SEM) observation is carried out to the obtained product, the result is as follows: figure 1 shown. figure 1 It was shown that gelatin, polypyrrole and tannic acid were cross-linked with each other to form a supramolecular hydrogel with a pore size of about 15-30 μm.

[0038] The obtained product and raw materials were characterized by Fourier transform infrared spectroscopy, and the results were as follows: figure 2 shown. figure 2 It was shown that the intensity and frequency of the amide II absorption band of the product in the spectrum did not change significantly, indicating that polypyrrole had been successfull...

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Abstract

The invention belongs to the technical field of high polymer materials. The invention provides supramolecular hydrogel as well as a preparation method and application thereof. The preparation method of the supramolecular hydrogel comprises the following steps: mixing gelatin and pyrrole, and then adding an oxidizing agent for polymerization to obtain a mixed solution; and adding tannic acid to the mixed solution for crosslinking, and the supramolecular hydrogel is obtained. Pyrrole is polymerized under the action of an oxidizing agent to obtain polypyrrole, and tannic acid contains rich phenolic hydroxyl groups. The preparation method is easy to operate and short in gelling time, and the prepared supramolecular hydrogel has good plasticity and electroactivity and can be self-healed at room temperature without being stimulated by external conditions. The supramolecular hydrogel has a three-dimensional porous structure, is beneficial to transmission of nutrient substances and electrons, has mechanical properties matched with nervous tissues, can be clinically applied to tissue engineering nerve conduits and damaged nerve repair, and has a great application prospect in the aspect of nerve injury repair.

Description

technical field [0001] The application belongs to the technical field of polymer materials, and in particular relates to a supramolecular hydrogel and its preparation method and application. Background technique [0002] Peripheral nerves are delicate and unprotected tissues that are vulnerable to natural disasters, industrial injuries, traffic accidents, war, and systemic diseases such as diabetes and cancer. Peripheral nerve injury has become a serious problem that plagues human health, and about 2.8% of patients suffer from peripheral nerve injury in surgical trauma every year. In the United States, more than 200,000 new cases of peripheral nerve injury occur each year, costing approximately $1.5 billion in healthcare costs. More than 300,000 people in Europe also suffer from peripheral nerve injuries every year. [0003] Hydrogel is a kind of polymer material, which can be obtained by chemical cross-linking or physical cross-linking of natural and synthetic polymers, h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/22A61L27/18A61L27/52A61L27/50C08J3/075C08J3/24C08L89/00C08L79/04C08G73/06
CPCA61L27/222A61L27/18A61L27/52A61L27/50C08J3/075C08J3/246C08G73/0611A61L2430/32C08J2389/00C08J2479/04C08L89/00C08L79/04
Inventor 谭帼馨李晓君周蕾
Owner GUANGDONG UNIV OF TECH
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