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3D printed all-through tubular hydrogel support and preparation method thereof

A 3D printing and hydrogel technology, applied in manufacturing, medical science, liquid material additive processing, etc., can solve the problems of low precision of tubular structures, large selection limitations, slow speed, etc., and achieve flexible size controllability , the preparation process is simple, the effect of mild reaction conditions

Inactive Publication Date: 2019-11-08
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, based on the forming method of printing the physical edge of the tubular structure layer by layer, the tubular structure constructed by the direct printing method has low precision and slow speed; The obstacles in the real sense have not achieved full penetration; the post-processing process of the sacrificial material method is cumbersome to operate, and the selection of sacrificial materials is relatively limited

Method used

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  • 3D printed all-through tubular hydrogel support and preparation method thereof
  • 3D printed all-through tubular hydrogel support and preparation method thereof
  • 3D printed all-through tubular hydrogel support and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 4.5 g chitosan and 0.5 g gelatin powder were dispersed in 100 g of 1 vol.% acetic acid aqueous solution, stirred at 20 °C for 8 h to form a transparent solution, and then poured into a 30 cc printing cartridge and sealed. Stand in an oven at 30°C for 48 hours to remove air bubbles in the solution to obtain a chitosan / gelatin composite solution. Set the barrel temperature of the 3D printer to 40 °C, the extrusion pressure to 1.0 bar, and the traction speed to 50 mm / s, print on a platform at 4 °C, and obtain thermally reversible chitosan / gelatin based on gelatin gel curing Composite hydrogel scaffolds. Soak the above-mentioned hydrogel scaffold in 0.1 mol / L sodium thiosulfate aqueous solution for 1 min, take it out and cut off the edge end of the hydrogel scaffold, and then heat-wash it in deionized water at 20 °C for 60 min, and finally get a A three-dimensional hydrogel scaffold with a fully penetrating tubular structure.

[0033] figure 1 It is a schematic diagram o...

Embodiment 2

[0037] Disperse 9 g of chitosan and 9 g of collagen powder in 100 g of 5.5 vol.% acetic acid aqueous solution, stir at 40 °C for 6 h to form a transparent solution, then pour it into a 30 cc printing cartridge and seal it. Let it stand in an oven at 40 °C for 40 h to remove air bubbles in the solution to obtain a chitosan / collagen composite solution. Set the barrel temperature of the 3D printer to 50 °C, the extrusion pressure to 2.0 bar, and the traction speed to 40 mm / s, print on a platform at 8 °C, and obtain thermally reversible chitosan / collagen based on collagen gel curing Composite hydrogel scaffolds. Soak the above-mentioned hydrogel scaffold in 1.0 mol / L sodium citrate aqueous solution for 30 minutes, take it out and cut off the edge end of the hydrogel scaffold, and then wash it in deionized water at 40 ℃ for 50 minutes, and finally get a three-dimensional A hydrogel scaffold that runs through the tubular structure.

Embodiment 3

[0039] Disperse 4.95 g sodium alginate and 22.55 g collagen in 100 g deionized aqueous solution, stir at 55 °C for 4.5 h to form a transparent solution, then pour it into a 30 cc printing cartridge, seal it, and place it in a 55 °C oven Stand still for 30 h to remove air bubbles in the solution to obtain a sodium alginate / collagen composite solution. Set the barrel temperature of the 3D printer to 70 °C, the extrusion pressure to 3.5 bar, and the traction speed to 30 mm / s, print on a platform at 12 °C, and obtain thermally reversible sodium alginate / collagen based on collagen gel curing. Composite hydrogel scaffolds. Soak the above-mentioned hydrogel scaffold in 2.5 mol / L calcium chloride aqueous solution for 50 minutes, take it out and cut off the edge end of the hydrogel scaffold, and then wash it in deionized water at 55 ℃ for 35 minutes, and finally get a three-dimensional A hydrogel scaffold that runs through the tubular structure.

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Abstract

The invention discloses a 3D printed all-through tubular hydrogel support and a preparation method thereof. The method comprises the following steps that a, a polyion type / thermo-sensitive type complex solution is prepared and poured into a 3D printing material cylinder; b, printing parameters are set, and printing is conducted on a low-temperature platform to obtain a heat-reversible composite hydrogel support; c, the support is soaked in an ionic cross-linking agent aqueous solution for a period of time and then taken out; and d, after the edge tail end of the support is removed and then thesupport is soaked in deionized water for thermal washing treatment to obtain the hydrogel support with an all-through tubular structure. According to the support and the method, based on the difference of the thermal stability of the composite hydrogel before and after ion crosslinking, the spatial effect of 3D printing and the time effect of ion diffusion are combined, the process is simple, theprepared tubular hydrogel support has good structural connectivity and size regulation and control, and has a potential application prospect in the field of vascular tissue engineering.

Description

technical field [0001] The invention relates to the field of 3D printing hydrogels, in particular to a 3D printing full-through tubular hydrogel scaffold and a preparation method thereof. Background technique [0002] In recent years, 3D printing technology has developed rapidly. With the help of computer-aided software, the personalized construction of complex models can be realized through the design of material structures, and it is widely used in the field of tissue engineering. Hydrogel has become the most commonly used bioink for 3D printing because of its physical and chemical properties similar to human tissue. Traditional 3D printed hydrogel scaffolds are stacked by solid primitives, which reduces the porosity of the material. Moreover, the porous structure formed between the primitives is in the shape of a three-dimensional ladder extension, without forming a straight channel shape, and has strong fluid resistance in hydrodynamics, which is not conducive to the in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C64/106B33Y10/00A61L27/52A61L27/48
CPCA61L27/48A61L27/52B33Y10/00B29C64/106C08L5/08C08L5/04C08L5/12C08L89/00
Inventor 董华温宏基曹晓东
Owner SOUTH CHINA UNIV OF TECH
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