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Double-layer small-caliber nanofiber tissue engineering blood vessel stent and preparation method thereof

A vascular stent and tissue engineering technology, applied in the field of double-layer small-diameter nanofiber tissue engineering vascular stent and its preparation, vascular repair or vascular replacement material, to achieve non-thrombosis, huge application potential, excellent mechanical properties and biocompatibility Effect

Inactive Publication Date: 2019-01-11
ZHONGYUAN ENGINEERING COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, there is no ideal technical product for preparing micro-diameter blood vessel (inner diameter less than 6mm) tissue in the world for clinical medicine. Angiogenesis stent based on vascular regeneration stent in vivo is an urgent need for clinical medicine.

Method used

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  • Double-layer small-caliber nanofiber tissue engineering blood vessel stent and preparation method thereof
  • Double-layer small-caliber nanofiber tissue engineering blood vessel stent and preparation method thereof
  • Double-layer small-caliber nanofiber tissue engineering blood vessel stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A double-layer small-diameter nanofiber tissue engineering stent, including an inner layer of a tissue engineering stent and an outer layer of a tissue engineering stent, the inner layer of the tissue engineering stent and the outer layer of the tissue engineering stent are included in the core yarn by electrospinning in sequence After the electrospinning is completed, the core yarn of the core-spun yarn is extracted to obtain a tissue engineering vascular stent. Based on the nanofiber core-spun yarn technology, the core-spun yarn with a double-layer nanofiber structure is prepared, and the vascular stent that mimics the natural blood vessel can be obtained by pulling out the core filament.

[0027] The inner layer of the tissue engineering stent is prepared by electrospinning from a spinning solution prepared from silk fibroin and a polymer at a mass ratio of 95:5, and the outer layer of the tissue engineering stent is a spinning solution prepared from a polymer. The s...

Embodiment 2

[0033]A double-layer small-diameter nanofiber tissue engineering stent, including an inner layer of a tissue engineering stent and an outer layer of a tissue engineering stent, the inner layer of the tissue engineering stent and the outer layer of the tissue engineering stent are included in the core yarn by electrospinning in sequence After the electrospinning is completed, the core yarn of the core-spun yarn is extracted to obtain a tissue engineering vascular stent. Based on the nanofiber core-spun yarn technology, the core-spun yarn with a double-layer nanofiber structure is prepared, and the vascular stent that mimics the natural blood vessel can be obtained by pulling out the core filament.

[0034] The inner layer of the tissue engineering stent is prepared by electrospinning a spinning solution prepared by mass ratio of silk fibroin and polymer (95:5-85:15), and the outer layer of the tissue engineering stent is The spinning solution prepared for the polymer was prepar...

Embodiment 3

[0052] A double-layer small-diameter nanofiber tissue engineering stent, including an inner layer of a tissue engineering stent and an outer layer of a tissue engineering stent, the inner layer of the tissue engineering stent and the outer layer of the tissue engineering stent are included in the core yarn by electrospinning in sequence After the electrospinning is completed, the core yarn of the core-spun yarn is extracted to obtain a tissue engineering vascular stent. Based on the nanofiber core-spun yarn technology, the core-spun yarn with a double-layer nanofiber structure is prepared, and the vascular stent that mimics the natural blood vessel can be obtained by pulling out the core filament.

[0053] The inner layer of the tissue engineered stent is prepared by electrospinning a spinning solution prepared from silk fibroin and polymer at a mass ratio of 87:13, and the outer layer of the tissue engineered stent is spun by polymer. The silk solution was prepared by electro...

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Abstract

The invention discloses a double-layer small-caliber nanofiber tissue engineering blood vessel stent and a preparation method thereof. The double-layer small-caliber nanofiber tissue engineering bloodvessel stent comprises an inner layer of a tissue engineering blood vessel stent and an outer layer of the tissue engineering blood vessel stent, wherein the inner layer of the tissue engineering blood vessel stent and the outer layer of the tissue engineering blood vessel stent are sequentially electrospun to obtain a core-spun yarn on the core yarn, and after the electrospinning is completed, the core yarn of the core-spun yarn is extracted to obtain a tissue engineering blood vessel stent. As the blood vessel tissue engineer stent material with micro and small caliber has a multi-layer structure and composition of the bionic natural blood vessel to a certain extent, the blood vessel tissue engineer stent material has good biocompatibility, is not easy to generate thrombus and has sufficient viscoelasticity so that the blood vessel tissue engineering stent material can withstand the pressure in the blood vessel for a long time.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a double-layer small-diameter nanofiber tissue engineering blood vessel support and a preparation method thereof, which are applied to blood vessel repair or blood vessel replacement materials. Background technique [0002] Cardiovascular disease is one of the common diseases that endanger human health. According to the data of "China Cardiovascular Disease Report", the prevalence of cardiovascular disease risk factors in China is obvious, leading to a continuous increase in the number of cardiovascular diseases. When a blood vessel in a certain part of the human body cannot supply blood normally due to reasons such as arteriosclerosis, thrombosis, aging or damage, surgical treatment such as blood vessel replacement and bypass surgery is required. There are two types of surgical blood vessels: biological blood vessels and artificial blood vessels. Biological blood ...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61F2/06
CPCA61F2/06A61L27/507A61L2400/12
Inventor 邵伟力何建新刘凡周玉嫚崔世忠王芳芳强荣李梦营王琳琳张景李方陶雪姣翁凯岳万里陈元昆
Owner ZHONGYUAN ENGINEERING COLLEGE
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