41results about How to "Less prone to thrombosis" patented technology

The present invention is specifically directed to a heart occlusion device with a self-centering mechanism. The heart occlusion device includes two separate uniquely shaped wires 12, 14, each forming shapes that mirror the respective wire's shapes. Each wire forms half-discs or quarter-discs that together form a distal disc and a proximal disc. In other versions, the device includes four separate wires, each mirroring its neighboring wire and forming a proximal and a distal quarter-disc. In the versions with four wires, the quarter-discs of each wire together form proximal and distal discs. The distal disc and proximal disc are separated by a self-centering waist. The proximal disc is attached to a hub comprising a screw mechanism. A similar hub is optional on the distal disc. The discs further include coverings which form a sealant to occlude an aperture in a tissue. The wires forming the discs have a shape-memory capability such that they can be collapsed and distorted in a catheter during delivery but resume and maintain their intended shape after delivery.

A method of coating implantable open lattice metallic stent prosthesis is disclosed which includes sequentially applying a plurality of relatively thin outer layers of a coating composition comprising a solvent mixture of uncured polymeric silicone material and crosslinker and finely divided biologically active species, possibly of controlled average particle size, to form a coating on each stent surface. The coatings are cured in situ and the coated, cured prosthesis are sterilized in a step that includes preferred pretreatment with argon gas plasma and exposure to gamma radiation electron beam, ethylene oxide, steam.

A peripheral stent with individual segments reduces the occurrence of fatigue fracture failure seen in vessels and tubes having bending and twisting movement. Segments can be attached via connecting fibers that biodegrade and offer the segments freedom of movement. The segments are balloon-expandable but will not be crushed by external forces placed upon the stent. Hinges and struts provide the stent with a plastic deformation during expansion and remain elastic if exposed to an oval shape. The segments overlap each other to provide improved scaffolding of the vessel wall and a greater flexibility during delivery. A composite stent having both balloon-expandable and self-expanding character has application in the venous system.

The invention relates to a blood pump for assisting blood flow in the heart, in particular to an artificial heart blood pump with magnetic and fluid dynamic pressure hybrid suspension, which comprises a casing 7 sleeved on an inner shell 9; wherein the casing comprises a motor stator 8 and the inner shell 9 comprises a head support component 1, a rotor component and a rear support component 15. The blood bump is characterized in that the rotor component, the head support component 1 and the rear support component 15 are arranged in the cylindrical inner shell 9; the rotor component is arranged between the head support component 1 the rear support component 15; wherein a head blood dynamic pressure suspension cone bearing 2 is positioned at the central head support component 1; the rotor component comprises a head blood dynamic pressure suspension cone 3, an impeller 6, a rear permanent magnet bearing inner ring 10 and a rear blood dynamic pressure suspension cone 13 in series; a rear blood dynamic pressure suspension cone bearing 14 is arranged at the central rear support component 15 and a rear permanent magnet bearing external ring 12 is embedded on the outside of the bearing. The blood pump has the advantages of low shearing force of the blood, less damage to blood erythrocytes and decreased hemolysis.

A high-molecular film covering on the surface of medical internal marmem supporter for insertion therapy is composed of internal, external and miniporous films. The said supporter has better elasticity, biological compatibility and medicine carrying power. It is used for esophagus, trachea, blood vessel, biliary trace and urethra.

The invention provides a compact axial-flow magnetic-levitation artificial heart pump, in particular to an artificial heart pump characterized in that two permanent magnet bearings and a mix of radial magnetic bearing suspension, and the radial magnetic bearing and a permanent magnet motor share a stator and a rotor. The compact axial-flow magnetic-levitation artificial heart pump has the structure that the compact axial-flow magnetic-levitation artificial heart pump comprises a stator assembly, a rotor assembly, a front guidance impeller and a rear guidance impeller; a taper-shaped or axial permanent magnet bearing is respectively formed by a first permanent magnet (9) and a right permanent magnet ring (14) as well as a second permanent magnet (19) and a left permanent magnet ring (18) to realize the purpose that the rotor axially supports in a suspension mode; a torque coil (5) and a suspension coil (7) are respectively wound on a motor stator (6); and with a certain decoupling control algorithm, the motor stator not only generates torque force but also generates radial suspension support force. In the compact axial-flow magnetic-levitation artificial heart pump, the rotor is supported by permanent magnetic force and electromagnetic force, and the compact axial-flow magnetic-levitation artificial heart pump has the advantages of small damage on blood, less radiation, compact structure and the like, is easy to transplant, is suitable for patients suffering from cardiac function failure, heart diseases and the like and can be used for ventricular assisting for a long time or a short time.

The invention relates to a blood pump for assisting blood flow in the heart, in particular to an artificial heart blood pump with magnetic and fluid dynamic pressure hybrid suspension, which comprisesa casing 7 sleeved on an inner shell 9; wherein the casing comprises a motor stator 8 and the inner shell 9 comprises a head support component 1, a rotor component and a rear support component 15. The blood bump is characterized in that the rotor component, the head support component 1 and the rear support component 15 are arranged in the cylindrical inner shell 9; the rotor component is arrangedbetween the head support component 1 the rear support component 15; wherein a head blood dynamic pressure suspension cone bearing 2 is positioned at the central head support component 1; the rotor component comprises a head blood dynamic pressure suspension cone 3, an impeller 6, a rear permanent magnet bearing inner ring 10 and a rear blood dynamic pressure suspension cone 13 in series; a rear blood dynamic pressure suspension cone bearing 14 is arranged at the central rear support component 15 and a rear permanent magnet bearing external ring 12 is embedded on the outside of the bearing. The blood pump has the advantages of low shearing force of the blood, less damage to blood erythrocytes and decreased hemolysis.

The present invention is directed to a novel poly (diol citrates)-based coating for implantable devices. More specifically, the specification describes methods and compositions for making and using implantable devices coated with citric acid copolymers or citric acid copolymers impregnated with therapeutic compositions and / or cells.

A high-molecular film covering on the surface of medical internal marmem supporter for insertion therapy is composed of internal, external and miniporous films. The said supporter has better elasticity, biological compatibility and medicine carrying power. It is used for esophagus, trachea, blood vessel, biliary trace and urethra.

The invention discloses an electromagnetic-permanent magnetism bidirectional driving type artificial heart pump employing artificial heart elastic blood sacs with simple structure and easy making; two nipple-shape bosses facing inwards and outwards are arranged on the elastic blood sac, and respectively provided with a central hole, thus replacing artificial heart valves of complex structures, and realizing unidirectional imbibition and unidirectional apocenosis; the artificial heart elastic blood sacs are driven by an electromagnetic-permanent magnetism bidirectional driving mechanism having only one armature, so the two elastic blood sacs are alternatively switch between a diastole work state and a contraction work state, thus alternatively realizing imbibition and apocenosis process, outputting pulse type blood flow like a natural heart, preventing technical directional errors of a continuous blood pump, and well simulating the work process of the natural heart; in addition, the elastic blood sacs are made of elastic telescopic materials, streamline form is realized inside, so cells in the blood cannot be damaged, and thromboses are hard to form, thus well replacing the work of a natural heart of a human being or vertebrate.

The invention provides a lateral aortic balloon counterpulsation cardiac ventricle donkey pump, which consists of a hard shell, a balloon, an air inlet pipe which connects a drive unit and the lateral aortic balloon counterpulsation cardiac ventricle donkey pump, and a blood pipe which connects a posterior aorta and a cardiac ventricle donkey pump and is used for blood to flow, wherein the balloon splits the hard shell into an air receiving cavity and a blood receiving cavity. Compared with the prior intra-aortic balloon counterpulsation pump, the lateral aortic balloon counterpulsation cardiac ventricle donkey pump has the advantages of simple structure, low production cost, convenient use and high use safety, not only can be arranged inside a thoracic cavity but also can be arranged in vitro during operation and postoperative recovery, has good effects of lightening the afterload of a left ventricle and improving blood supply of coronary arteries because the mounting position of the lateral aortic balloon counterpulsation cardiac ventricle donkey pump is close to the heart, and has stable treatment effect. Moreover, the blood enters in and out from the same pipe, so that thrombus is difficult to generate.

The invention relates to a drug coating balloon and a preparation method thereof. The drug coating balloon comprises a balloon body and a drug coating arranged on the outer surface of the balloon body. The drug coating comprises a bottom coating, an interlayer coating and a top coating which are sequentially stacked. The bottom coating is used for increasing the adhesion and firmness of the drug coating to the balloon body, so as to reduce the drug loss in the conveying process and increase the utilization rate of a drug. The interlayer coating is used for loading a drug and helping the drug to be better absorbed by tissues. The top coating is used for promoting the attachment of the drug coating and the intima of the vascular wall, so that the tissue absorption capability of the drug is better facilitated.

The invention provides a ventricular auxiliary device for the right heart of a child, belongs to the field of medical instruments, and solves the problems that an existing sliding bearing is prone to heating, blood coagulation is caused by heating, thrombus is further caused and the like, the ventricular auxiliary device comprises a pump cylinder and a rotor arranged in the pump cylinder, and a liquid inlet is formed in one end of the pump cylinder; a liquid inlet is formed in one end of the pump cylinder, a liquid outlet is formed in the other end of the pump cylinder, the rotor can rotate to enable blood to flow from the liquid inlet to the liquid outlet, the two ends of the rotor are connected with supporting pieces through rotating shafts, the supporting pieces are connected with the rotating shafts through bearings, and the bearings are provided with a plurality of open grooves. The magnetic core can be driven by in-vitro magnetic coupling driving equipment to rotate, and the magnetic core can rotate to drive the hub to rotate. The heating phenomenon at the joint of the rotating shaft and the bearing can be reduced, and thrombus is not prone to being generated.

The invention discloses a double-plunger cylinder driving artificial heart pump. An elastic haematodocha used for an artificial heart which is simple in structure and convenient in manufacturing is used, and two nipple-shaped bulges on the elastic haematodocha are used to replace a heart valve prosthesis which is extremely complex in structure, the inward nipple-shaped bulge and the outward nipple-shaped bulge being provided with holes on the center, thereby realizing one-way imbibition and one-way drainage. And the elastic haematodocha is driven by a double-plunger cylinder driving mechanism, so that the elastic haematodocha converts between a diastole operating state and a shrinkage operating state in turns, so as to realize processes of imbibitions and drainage in turns. The artificial heart pump can output impulse type blood flow similar to a natural heart, preventing technical directivity faults of a continuous blood pump, and preferably imitating operating process of a natural heart. The elastic haematodocha is made of an elastic scalable material, the internal of the elastic haematodocha is streamline, and would not damage cells in blood, and thrombus is not easy to form. The double-plunger cylinder driving artificial heart pump can preferably replace operation of a natural heart of a human or a vertebrate.

The invention discloses a small-caliber composite multilayer artificial blood vessel and a preparation method thereof. A chitosan / gelatin mixed solution is prepared as an electrolyte, and an electrophoretic deposition technology is utilized to deposit chitosan / gelatin composite gel on the surface of a needle-shaped electrode, so that a chitosan / gelatin composite gel coating is prepared; the composite gel coating is taken as a substrate, and a sodium alginate / chitosan outer layer is constructed on the surface of the composite gel coating by utilizing the layer-by-layer self-assembly effect to form chitosan / gelatin / sodium alginate composite multilayer gel; and after the composite multilayer gel is taken down, freeze drying is performed to obtain the chitosan / gelatin / sodium alginate compositemultilayer artificial blood vessel capable of simulating the special multilayer structure of the natural blood vessel. By means of the mode, the artificial blood vessel small in caliber and good in mechanical property can be rapidly and conveniently prepared; and the whole preparation process is easy to regulate and control, and the prepared composite multilayer artificial blood vessel is good inbiocompatibility, high in use safety and capable of meeting the requirements of practical application.

The invention discloses an elastic haematodocha for artificial heart and an air-bag-driven artificial heart pump. The air-bag-driven artificial heart pump adopts an elastic haematodocha for artificial heart which is simple in structure and convenient to make. An inward nipple-like protrusion having a hole in the center and an outward nipple-like protrusion having a hole in the center on the elastic haematodocha substrate an artificial heart valve prosthesis being extreme complex in structure, so that unidirectional imbibition and unidirectional apocenosis can be achieved, an air bag driving mechanism only having one tracheae inserted in the body is used for driving the elastic haematodocha to work, so that the elastic haematodocha can alternate between a diastole work state and a contraction work state, so as to alternate imbibition and apocenosis, to output a pulse blood flow like that output from a natural heart, so that a work process of the natural heart can be well simulated. At the same time, the elastic haematodocha is made from elastic telescopic material, the inner of the elastic haematodocha is a streamline structure which does not destroy cells in the blood, and thrombus will not be generated, so the elastic haematodocha for the artificial heart and the air-bag-driven artificial heart pump can substrate humans' or vertebrate natural hearts to work.

The invention relates to a vaneless blood pump. The vaneless blood pump comprises a volute, at least one separating piece, a rotor, a diversion piece and a power device; the volute is provided with a first cavity, a first liquid inlet and a first liquid outlet, wherein the first liquid inlet and the first liquid outlet are communicated with the first cavity; the separating piece and the rotor are arranged in the first cavity; the separating piece is provided with a second cavity, a second liquid inlet and a second liquid outlet, wherein the second liquid inlet and the second liquid outlet are communicated with the second cavity; the rotor is sleeved with the separating piece and fixedly connected with the separating piece through the diversion piece; a laminar flow channel is formed between the inner wall of the separating piece and the outer wall of the rotor. By supplying blood in this mode, the blood which needs to be supplied can flow in a laminar flow state, so that phenomena of hemolysis and thrombosis do not occur to the blood easily; meanwhile, the blood is not squeezed in the laminar flow mode, the damage to the blood is relatively small, long-term blood supplying can be conducted, the requirements of long-term blood supplying can be met, and the quality of the blood is ensured.

The invention relates to an artificial blood vessel and a preparation method thereof. The artificial blood vessel adopts a hollow circular pipe structure, and comprises a base layer, a binding layer and a bioglass layer which are sequentially connected from the inner part to the outer part, wherein the base layer adopts a styrene-isobutene block copolymer. The preparation method comprises the steps of performing injection molding, performing cleaning and drying, forming the binding layer and the bioglass layer and the like. The prepared artificial blood vessel is stable to exist in human bodies, and is good in bridging and suturing properties during operations, and thrombosis is not liable to form. Human tissue can rapidly admit and be compatible to form fixed tissue, and the artificial blood vessel has broad application prospects.

The invention provides an indwelling needle. The indwelling needle comprises an indwelling needle seat, an isolation plug, a catheter, a puncturing steel needle, a stop block, a plurality of limitingblocks and a baffle, wherein the indwelling needle seat comprises an inner cavity; the isolation plug is arranged in the inner cavity; the catheter is arranged at one end of the indwelling needle seat; one end of the puncturing steel needle punctures the isolation plug and extends out of the catheter; the stop block is clamped in the indwelling needle seat and abuts against the isolation plug; theplurality of limiting blocks are circumferentially arranged in one end, away from the catheter, of the indwelling needle seat; the baffle is arranged in the inner cavity and connected with the stop block through a spring, the spring sleeves the puncturing steel needle, and a plurality of openings matched with the plurality of limiting blocks in shape and size are formed in the edge of the baffle;the baffle is rotated, and when the plurality of openings in the baffle correspond to the plurality of limiting blocks, the plurality of openings in the baffle penetrate through the plurality of limiting blocks; the baffle is rotated, and when the plurality of openings in the baffle and the plurality of limiting blocks are staggered, the baffle is limited. The puncturing steel needle cannot puncture a medical worker due to protection of the spring, and medical infection is avoided.

The invention discloses a preparation method of a novel biological acellular implant material. The preparation method of the novel biological acellular implant material comprises the following steps: (1) carrying out raw material selection; (2) carrying out pretreatment; (3) carrying out material treatment; (4) carrying out material processing; and (5) storing the material finished product. According to the material disclosed by the invention, ascaris lumbricoides which can parasitize in the human body or the animal body are selected, the body wall bag of ascaris lumbricoide is taken as a raw material and is processed to prepare the biomedical material capable of being transplanted to the human body, the tissue compatibility of the material is good, and the material can replace the autologous tissue and partial functions of the human body.

The invention discloses a motor-bidirectional spiral-drive artificial heart pump. Through using an elastic haematodocha used for an artificial heart, the elastic haematodocha being simple in structure and convenient in manufacturing, two nipple-shaped bulges on the elastic haematodocha are used to replace a heart valve prosthesis which is extremely complex in structure, the inward nipple-shaped bulge and the outward nipple-shaped bulge being provided with holes on the center, thereby realizing one-way imbibition and one-way drainage. And the elastic haematodocha is driven by a motor-bidirectional spiral-drive mechanism, so that the elastic haematodocha converts between a diastole operating state and a shrinkage operating state in turns, so as to realize processes of imbibitions and drainage in turns. The artificial heart pump can output impulse type blood flow similar to a natural heart, preventing technical directivity faults of a continuous blood pump, and preferably imitating operating process of a natural heart. The elastic haematodocha is made of an elastic scalable material, the internal of the elastic haematodocha is streamline, and would not damage cells in blood, and thrombus is not easy to form. The motor-bidirectional spiral-drive artificial heart pump can preferably replace operation of a natural heart of a human or a vertebrate.

Disclosed are a magnetospirillum magneticum, a preparation method therefor, and a use thereof. In the preset invention, a magnetospirillum magneticum Magnetospirillum sp. ME-1, CCTCC No: M2013260 which can produce superparamagnetic magnetosomes is separated fresh water. The strain is a magnetospirillum magneticum with a size of 2.62~4.83×0.44~0.62μm, and comprises a magnetosome chain consisting of 10 to 31 magnetosome particles. A component of each magnetosome is ferroferric oxide, is a cuboctahedron or an octahedron in shape, and has a size of 26±5nm which is in a superparamagnetic range. The magnetospirillum magneticum strain has a specific magnetosome gene island sequence and can produce magnetosomes with a yield of 177mg / L by directly using air fermental cultivation. The strain has excellent fermentability, and produces magnetosome particles which are superparamagnetic, and has a great industrialization popularization prospect.

A medical intramedullary venous return device comprises a hollow screw (1), a drill core (2), a guide core (3) and a venous anastomosis ring (4). A cavity of the hollow screw (1) is used cooperativelywith the drill core (2) and the guide core (3), the drill core (2) is mounted in the hollow screw (1) to serve as an integrated drilling-in medullary cavity (6), the drill core (2) is replaced with the guide core (3), and the drill core (2) is communicated with a return vein (7) through the venous anastomosis ring (4). A flap venous return scheme is provided under the conditions that a recipientarea has no ideal vein for anastomosis. The device uses a high-strength metal material combined with a more biocompatible polymer material to facilitate the realization of a corresponding function. The inner wall of the guide core made of a polymer material can be coated with a medicine sustained-release diaphragm, long-term anticoagulation is achieved, and the embolism of a return channel is prevented.

The invention discloses a preparation method of a compliance adjustable multi-layer composite artificial blood vessel and belongs to the technical field of artificial blood vessels. The preparation method comprises the following steps: (1) blending and granulating PCL, PLA and TPU in a mass ratio of (7-9): (1-3): (0-2); (2) melting and thermally pressing the granules at 190-220 DEG C to prepare afilm; (3) coating a solid cylinder with an aluminum foil layer, then coating the aluminum foil layer with the film, then coating an aluminum foil layer and putting the solid cylinder in a hollow cylinder, and then putting the cylinder in a high pressure reaction kettle to prepare a single-layered composite material foaming pipe by supercritical CO2 microcellular foaming; and (4) nesting three single-layered composite material foaming pipes of different elastic modulus, and filling the gaps between adjacent single-layered composite material foaming pipes with a gel or proteins to obtain the compliance adjustable multi-layer composite artificial blood vessel.

The invention discloses a preparation method of a novel biological acellular implant material. The preparation method of the novel biological acellular implant material comprises the following steps: (1) carrying out raw material selection; (2) carrying out pretreatment; (3) carrying out material treatment; (4) carrying out material processing; and (5) storing the material finished product. According to the material disclosed by the invention, ascaris lumbricoides which can parasitize in the human body or the animal body are selected, the body wall bag of ascaris lumbricoide is taken as a raw material and is processed to prepare the biomedical material capable of being transplanted to the human body, the tissue compatibility of the material is good, and the material can replace the autologous tissue and partial functions of the human body.

The invention relates to the technical field of medical instruments, in particular to a ventricular shunt device which comprises a conduction part, a first positioning body and a second positioning body, the first positioning body and the second positioning body are arranged on the two sides of the conduction part respectively, and the conduction part, the first positioning body and the second positioning body are formed by integrally weaving single weaving wires. In the embodiment of the utility model, by adopting the interaventricular shunting device, through an integrated weaving mode of a single weaving wire, treatment on bulk wire heads is not needed, no redundant structure protrudes into the left atrium and the right atrium after installation is completed, thrombus is not easy to generate, the structure is simple, the size is smaller during contraction, and the device is convenient to use. And the damage to the admission blood vessel is smaller in the implanting process.

The invention discloses a small-diameter composite multilayer artificial blood vessel and a preparation method thereof. The present invention prepares chitosan / gelatin composite gel coating as electrolyte by preparing chitosan / gelatin mixed solution, and utilizes electrophoretic deposition technology to deposit chitosan / gelatin composite gel on the needle electrode surface; Using the composite gel coating as the base, use layer-by-layer self-assembly to build an outer layer of sodium alginate / chitosan on its surface to form a composite multi-layer gel of chitosan / gelatin / sodium alginate; remove the composite After the multi-layer gel, the chitosan / gelatin / sodium alginate composite multi-layer artificial blood vessel that can simulate the special multi-layer structure of the natural blood vessel can be obtained by freeze-drying. Through the above method, the present invention can quickly and conveniently prepare artificial blood vessels with small diameter and good mechanical properties; and the overall preparation process is easy to control, and the prepared composite multi-layer artificial blood vessel has good biocompatibility and high safety in use, and can meet the actual application needs.

The invention discloses a guide wire recovery catheter for interventional operation and an application thereof. The guide wire recovery catheter comprises a catheter body and a straight sheathing canal sleeving on the catheter body, wherein the catheter body is made from a flexible material and is provided with a near end tubular structure and a far end flared structure connected to each other; the far end flared structure is configured such that when the straight sheathing canal shrinks, the far end flared structure extending out of the straight sheathing canal is unfolded outward through a self-recovery force. The catheter can be used for recovering guide wires, and can recover far end guide wire reversely smoothly in interventional operation, so that the problem of operation failure asthe guide wire cannot enter a positive catheter to establish a guide ware path when the far end artery is punctured reversely is solved, and meanwhile, a lot of time and vigor wasted for re-establishing the guide wire path are avoided, so that the X ray exposure time of doctors and patients is reduced.