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Preparation method of novel biological acellular implant material

An implant material and acellular technology, which is applied in the field of preparation of new biological acellular implant materials, can solve the problems of urethral stenosis and obstruction, poor anticoagulation of artificial blood vessels, poor adaptability of brain surface, etc., and achieves good material histocompatibility , Conducive to regeneration and repair, good strength and toughness

Active Publication Date: 2017-12-05
陈强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, the common polymer medical devices have their own shortcomings in the use process, such as meningeal products have adhesion, leakage, poor adaptability to the brain surface, and easy to cause infection. Artificial urethra is easy to cause urethral stricture and obstruction. Poor coagulation, long-term patency, easy to cause vascular intimal hyperplasia, etc.; although animal-derived medical devices have more advantages in use and effect, they also have problems such as the risk of zoonotic diseases
[0009] At present, there is a lack of a new biological decellularized implant material with better biocompatibility that can replace the body's own tissues and some functions

Method used

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  • Preparation method of novel biological acellular implant material

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Experimental program
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Embodiment 1

[0033] A preparation method of a novel biological decellularized implant material of the present invention, the novel biological decellularized implant material comprises the following steps:

[0034] (1) Raw material of the present invention: choose live Ascaris suum with a body length of less than 40 cm, male or female, and use it within 3 hours after the worm body dies;

[0035] (2) Pretreatment: After collecting the materials, kill them manually, then cut or dissect the insects according to the expected product, clean them with cleaning solution, and remove the contents of the body wall cavity as much as possible to obtain the required raw materials;

[0036] The cleaning solution is physiological saline.

[0037] (3) Material treatment: After the treated roundworm body wall capsule is treated with surfactant and protease, a biological scaffold with a three-dimensional structure is obtained;

[0038] The surfactant is triton-100, and the protease is a combination of pepsi...

Embodiment 2

[0045] The difference between embodiment 2 and embodiment 1 is:

[0046] A preparation method of a novel biological decellularized implant material of the present invention, the novel biological decellularized implant material comprises the following steps:

[0047] In step (1), the raw material of the present invention: select live Ascaris suum with a body length of less than 40 cm, male or female, and use it within 1 hour after the worm body dies;

[0048] In step (2), pretreatment: human execution after material collection, then cut or dissect the insect body according to the expected product, clean it with cleaning solution, remove the body wall cavity content as much as possible, and initially obtain the required raw materials;

[0049] The cleaning solution is a combination of physiological saline, sterilized water for injection and deionized water.

[0050] In step (3), material treatment: the processed roundworm body wall capsule is treated with surfactant and proteas...

Embodiment 3

[0057] The difference between embodiment 3 and embodiment 1 is:

[0058] A preparation method of a novel biological decellularized implant material of the present invention, the novel biological decellularized implant material comprises the following steps:

[0059] In step (1), the raw material of the present invention: select live Ascaris suum with a body length of 38 cm, male or female, and use it within 2 hours after the worm body dies;

[0060] In step (2), pretreatment: human execution after material collection, then cut or dissect the insect body according to the expected product, clean it with cleaning solution, remove the body wall cavity content as much as possible, and initially obtain the required raw materials;

[0061] The cleaning solution is sterile water for injection.

[0062] In step (3), material treatment: the processed roundworm body wall capsule is treated with a surfactant and protease to obtain a biological scaffold with a three-dimensional structure;...

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Abstract

The invention discloses a preparation method of a novel biological acellular implant material. The preparation method of the novel biological acellular implant material comprises the following steps: (1) carrying out raw material selection; (2) carrying out pretreatment; (3) carrying out material treatment; (4) carrying out material processing; and (5) storing the material finished product. According to the material disclosed by the invention, ascaris lumbricoides which can parasitize in the human body or the animal body are selected, the body wall bag of ascaris lumbricoide is taken as a raw material and is processed to prepare the biomedical material capable of being transplanted to the human body, the tissue compatibility of the material is good, and the material can replace the autologous tissue and partial functions of the human body.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a method for preparing a novel biological decellularized implant material. Background technique [0002] Surgery is the most common clinical treatment, and implantable medical devices play an indispensable role as a substitute for pathological tissues or organs. When abnormalities occur in human tissues or organs, operations such as clipping, ostomy, pressure limiting, support, hemostasis, shaping, and reconstruction of the diseased organ are usually required. At this time, a large number of medical device products are required. [0003] With the continuous improvement of clinical requirements for medical devices, the field of medical devices has also achieved great development in recent years, and various new implantable medical devices are emerging. At present, the raw materials of implantable medical devices have been used The earliest simple inorganic substanc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/50A61L15/42A61L15/40
CPCA61L15/40A61L15/42A61L27/3604A61L27/3675A61L27/3679A61L27/3687A61L27/507A61L2430/22A61L2430/32
Inventor 陈强贾敬亮陈有旺
Owner 陈强
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