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A preparation method of a multi-layer composite artificial blood vessel with adjustable compliance

A multi-layer composite and artificial blood vessel technology, applied in the field of artificial blood vessels, can solve problems such as difficult bionic human blood vessels, suture fatigue, solvents are difficult to completely remove, etc., to achieve the effect of overcoming the easy formation of thrombus, not easy to form thrombus, and enhancing patency

Active Publication Date: 2019-11-08
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(2) Due to the difference in the diameter expansion rate of the artificial blood vessel and the host blood vessel, excessive stress will be generated at the anastomosis, resulting in fatigue of the suture at the anastomosis, shear force of the host aorta, and fibrous tissue
In the prior art, most of the artificial blood vessels are prepared by electrospinning, but it is inevitable to introduce organic solvents to process the polymer materials, which are difficult to completely remove during the solvent volatilization process, and cause toxic and side effects to the human body in subsequent use
[0005] The construction of bionic artificial blood vessels is still in the exploratory stage in our country. Most of the current research uses single-layer artificial blood vessels, which is difficult to simulate the complex microstructure and functionality of human blood vessels.

Method used

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  • A preparation method of a multi-layer composite artificial blood vessel with adjustable compliance
  • A preparation method of a multi-layer composite artificial blood vessel with adjustable compliance
  • A preparation method of a multi-layer composite artificial blood vessel with adjustable compliance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A composite foam tube is made of PCL, PLA and TPU blended and foamed at a mass ratio of 80:10:10.

[0044] The composite material foam tube is prepared by the following method:

[0045] (1) PCL, PLA and TPU are blended and granulated according to the mass ratio of 80:10:10 on a twin-screw extruder;

[0046] (2) Set the temperature of the flat vulcanizing machine to 190°C. After the temperature is reached, put the pellets in a hollow steel plate with a thickness of 0.5mm, cover the upper and lower planes with a polytetrafluoroethylene film, put it into the heating plate, and wait for about 15 minutes. Melt, squeeze for about 5 minutes after melting, and take out the thin slice; perform secondary extrusion on the hot press to obtain a film with a thickness of about 0.2mm;

[0047] (3) Wrap a layer of aluminum foil paper (made of two layers of aluminum foil paper) around a solid cylinder with a diameter of 7mm, then wrap a film outside the layer of aluminum foil paper, an...

Embodiment 2

[0051] A composite material foam tube is made by blending and foaming PCL and PLA according to the mass ratio of 80:20, and its preparation method is the same as that of Example 1. The obtained product is designated as sample 2.

[0052] It was determined that the cell rate of the above sample 2 was 84.71%, the average size of the internal cell size was 10.06 μm, the cell size distribution was 10.06±3.3 μm, and the cell density was 2.55X10 8 piece / cm 3 , the modulus of elasticity is 4.86MPa, the tensile strength is 1.36MPa, and the elongation at break is 203%.

Embodiment 3

[0054] A composite material foam tube, which is made by blending and foaming PCL and PLA according to the mass ratio of 90:10, is designated as sample 3.

[0055] For the preparation process, refer to Example 1. The difference from the preparation process of Example 1 is that the diameter of the solid cylinder is 5.5 mm, and the inner diameter of the hollow cylinder is 6.5 mm.

[0056] It was determined that the cell rate of the above sample 3 was 88.52%, the average size of the internal cell size was 10.67 μm, the cell size distribution was 10.67±3.03 μm, and the cell density was 1.75×10 8 piece / cm 3 , the modulus of elasticity is 4.49 MPa, the tensile strength is 1.25 MPa, and the elongation at break is 326%.

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Abstract

The invention discloses a preparation method of a compliance adjustable multi-layer composite artificial blood vessel and belongs to the technical field of artificial blood vessels. The preparation method comprises the following steps: (1) blending and granulating PCL, PLA and TPU in a mass ratio of (7-9): (1-3): (0-2); (2) melting and thermally pressing the granules at 190-220 DEG C to prepare afilm; (3) coating a solid cylinder with an aluminum foil layer, then coating the aluminum foil layer with the film, then coating an aluminum foil layer and putting the solid cylinder in a hollow cylinder, and then putting the cylinder in a high pressure reaction kettle to prepare a single-layered composite material foaming pipe by supercritical CO2 microcellular foaming; and (4) nesting three single-layered composite material foaming pipes of different elastic modulus, and filling the gaps between adjacent single-layered composite material foaming pipes with a gel or proteins to obtain the compliance adjustable multi-layer composite artificial blood vessel.

Description

technical field [0001] The invention belongs to the technical field of artificial blood vessels, and in particular relates to a preparation method of a multi-layer composite artificial blood vessel with adjustable compliance. Background technique [0002] When the blood vessels in a certain part of the human body cannot guarantee the normal blood supply to the human body due to reasons such as aging, arteriosclerosis, embolism or damage, surgical operations such as artificial blood vessel replacement, bypass or intervention are required for treatment. [0003] Human blood vessels have a three-layer structure. Among the biomechanical properties of blood vessels, the most important thing is the compliance of blood vessels. Compliance refers to the expansion degree of the artificial blood vessel wall caused by the pressure in the lumen of the artificial blood vessel under normal diastolic pressure, that is, the relationship between the stress and the strain caused by the blood ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/50A61L27/40
CPCA61L27/18A61L27/50A61L27/507C08L67/04C08L75/04
Inventor 侯建华李倩郭海洋蒋晶王小峰裴莹
Owner ZHENGZHOU UNIV
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