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43 results about "Internal cell" patented technology

Intelligent energy distribution system and method for multiple battery modules

The invention belongs to the technical field of battery distribution management, and provides an intelligent energy distribution system and method for a multi-battery module, and the method comprises the steps: constructing a battery cell network topological graph according to the internal battery cells of a battery pack and the connection relation between the battery cells; according to the cell network topological graph, real-time voltage, current and temperature signals of part of cells in each battery module are obtained, and part of sampling observation data is formed; on the basis of a graph signal processing method, mapping part of sampling observation data into graph signals, estimating the state of an unsampled battery cell by adopting a graph Laplacian regularization method, detecting abnormal nodes in a graph on the basis of a state estimation value of the battery cell, and correspondingly identifying an abnormal battery cell; constructing an energy distribution model according to the state estimation value data of each battery cell, which is estimated by graph signal processing; risks caused by reduction of sampling wire harnesses and reduction of monitoring precision under a CTP architecture are effectively relieved, the cell state estimation precision and the energy distribution stability are improved, and the overall safe life of the battery pack is prolonged.
Owner:SHENZHEN RIZHAO INTELLIGENT TECH CO LTD

Battery module and battery assembly

A battery module (20) comprises a battery module housing (22), a plurality of battery cells (30), and a coolant (50), wherein the battery cells (30) and the coolant (50) are provided in the battery module housing (22), the coolant (50) being provided on the outside of the battery cells (30) to enable heat conduction, the battery cells (30) comprising a cell housing (32) with a safety valve (34), the safety valve (34) being configured to open when the internal cell pressure within the cell housing (32) rises above a predetermined first threshold value, thus enabling the outflow of a medium from the cell housing (32), the safety valves (34) being directed towards first regions (21) of the battery module housing (22), the battery module housing (22) having at least one opening (24) outside the first regions (21) which is closed by a rupture disc (26).
Owner:DR ING H C F PORSCHE AG

Transmission loss panel for aircraft cabin noise and thermal treatment

A vehicle panel includes two sidewalls and a resonator disposed between them on one of the cell walls. The resonator includes a network of cells, each cell defines an internal space to absorb and dissipate noise and vibrations within a specific frequency range. Certain cells or subsets of cells may be interconnected to define a larger internal cell space. An airgap between the resonator and one of the sidewalls may be partially or completely filled with dampening material to absorb high frequency noise. The dampening material may also provide thermal insulation.
Owner:BE AEROSPACE INC

bus bars

ActiveCN309784771SElectrical batteryBusbar
1. The name of the design product: busbar. 2. The use of the design product: for the current transmission, structural fixation, safety protection and heat dissipation management of the internal cell of the square battery. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.
Owner:JIANGSU HIGHSTAR BATTERY MFG CO LTD

A three-dimensional gradient negative poisson's ratio honeycomb skeleton structure and its preparation method and use

ActiveCN117366451BSheets/panelsIncreasing energy efficiencyMechanical metamaterialProsthesis
The application provides a three-dimensional gradient negative Poisson's ratio honeycomb skeleton structure and a preparation method and application thereof, and relates to the technical field of mechanical metamaterials; the external configuration of the three-dimensional gradient negative Poisson's ratio honeycomb skeleton structure is a circular truncated cone tube structure; the circular truncated cone tube structure comprises a plurality of curved surface concave hexagonal cells arranged around a central axis of the circular truncated cone tube structure and in a gradient along the circular truncated cone generatrix direction; the structure gradient can be first realized by relying on inherent characteristics of the inclined wall surface of the circular truncated cone tube structure, and further controlled by adjusting internal cell parameters; and the skeleton structure can be prepared by a 3D printing process. The three-dimensional gradient negative Poisson's ratio honeycomb skeleton structure has the characteristics of light self-weight, linear deformability, synergistic effects of structure gradient effects and negative Poisson's ratio effects, and deformation characteristics of flexible linear expansion under external load, and can be used in the fields of protective engineering, artificial intelligence, wearable devices, medical devices, artificial prostheses and the like.
Owner:INSTITUTE OF PROCESS ENGINEERING CHINESE ACADEMY OF SCIENCES

Battery cell cover plate, battery, and electric device

The application relates to a battery cell cover plate, a battery and an electric device, and belongs to the technical field of batteries. The application optimizes current distribution by differentiating the structures and positions of two pole columns. Two mounting holes are formed in a cover plate body and penetrate through a first pole column and a second pole column; the first pole column away from a center axis of the cover plate adopts a small-section column body, and the second pole column close to or coinciding with the center axis adopts a large-section column body; and the two pole columns are fixedly connected at the bottom of the cover plate through a connecting block. The application combines the current distribution characteristics of the battery internal cell pole group, cooperates the large-section column body with the small-section column body, makes the current distribution uniform, balances the pole column temperature rise, solves the local overheating problem caused by uneven current distribution of the traditional symmetrical pole column, and significantly improves the battery safety and service life.
Owner:SVOLT ENERGY TECHNOLOGY CO LTD

Pneumatic control pressurization type cell culture instrument

The invention discloses an air control pressurization type cell culture instrument in the technical field of cell culture instruments. The air control pressurization type cell culture instrument comprises a culture cabin, a cabin cover and a pressure detection unit, the cabin cover is provided with a dynamic pressure simulation module which is used for generating periodic dynamic pressure for simulating the respiratory rhythm of a human body in the culture cabin; in the process of culturing the cells in the human body, the driving mechanism is used for driving the moving plate, the elastic element and the piston to reciprocate, the pressure in the culture cabin fluctuates within a certain range, and the periodic change of the in-vivo pressure intensity when the human body breathes is simulated, so that the cells grow in a state closer to the in-vivo state; a more reliable in-vitro cell model is provided for subsequent research for revealing physiological and pathological mechanisms of a human body; and in the culture process, the detection mechanism and the compensation mechanism are used for supplementing or discharging gas into the culture cabin, so that the air pressure change caused by cell respiration in the culture cabin can be automatically adjusted.
Owner:PURCELL HIGH -TECH (SHANDONG) BIOTECHNOLOGY CO LTD

Closed-cell foaming material for backpack equipment

PendingCN121471619AElastomerPolymer science
The invention discloses a closed-cell foam material for backpack equipment, the closed-cell foam material is composed of matrix resin and an elastomer component, the matrix resin is an ethylene-vinyl acetate copolymer in which the content of a vinyl acetate structural unit is 5%-15%; the closed-cell foaming material has the overall density of 0.05-0.08 g / cm < 3 >, and the average diameter of internal cells is not larger than 200 microns; the closed cell foam material exhibits a compression set rate of less than 5%. According to the closed-cell foaming material for the backpack equipment provided by the invention, light weight, high resilience and deformation resistance are realized through collaborative design of materials and a process.
Owner:FILA SPORTS CO LTD

Systems and methods for a battery cell odometer with internal resistance self-test

Systems and methods are disclosed herein for determining the remaining useful life of a battery cell that includes the battery cell's internal resistance and / or shock loading. In one example implementation, the systems and methods disclosed herein monitor acceleration information over time based on information received from an accelerometer integrated in a battery cell and electrical information for at least one electrical parameter of the battery cell over time. The information is stored for determining remaining useful life. In another example implementation, the systems and methods disclosed herein determine a voltage drop across the battery cell and a current output of the battery cell. The systems and methods determine an internal cell resistance of the battery cell based on charge or discharge voltage and current information.
Owner:KYMA BATTERIES LLC

A broken wall device for traditional Chinese medicine decoction pieces production

This utility model belongs to the technical field of cell wall breaking devices, and in particular, it is a cell wall breaking device for the production of traditional Chinese medicine decoction pieces. It includes an outer shell with an internal cell wall breaking chamber, a base located at the bottom of the outer shell and housing a motor, and blades installed inside the cell wall breaking chamber. The heat dissipation assembly includes a cooling chamber located below the motor, a receiving space inside the cell wall breaking chamber, a circulating pump located on top of a partition and connected at one end to a cooling pipe, an inlet pipe located at the other end of the circulating pump, and an outlet pipe located at the end of the cooling pipe away from the circulating pump. This device can simultaneously remove heat generated by the motor and the cell wall breaking chamber during the cell wall breaking process of the traditional Chinese medicine decoction pieces. This not only ensures stable heat dissipation of the motor during long-term operation, preventing damage or performance degradation due to overheating, but also absorbs the heat generated by the traditional Chinese medicine decoction pieces during the cell wall breaking process, avoiding the charring problem caused by heat accumulation in the decoction pieces, thus improving the quality of the traditional Chinese medicine decoction pieces.
Owner:ANHUI JIAKAI PHARM CO LTD

Magnetic cell sorting device

The utility model discloses a magnetic cell sorting device which comprises a coil lifting mechanism, an electrified coil is clamped on the left side wall of the coil lifting mechanism, and the coil lifting mechanism comprises a stand column, a top plate fixedly connected to the top of the left side of the stand column and an electric telescopic rod fixed to the upper surface of the top plate. A telescopic shaft penetrating through the top plate is connected to a telescopic shaft of the electric telescopic rod, a movable block is fixedly connected to the bottom end of the telescopic shaft, and two servo electric cylinders are fixed to the left side of the movable block. According to the scheme, the electrified coil and the magnetic ring are arranged on the periphery of the separation column, the coil and the magnetic ring are used for manufacturing a magnetic field on the periphery of the separation column to attract nanometer magnetic beads in the separation column to move, the coil lifting mechanism is matched to pull the coil and the magnetic ring to reciprocate up and down, and then magnetic force drives the nanometer magnetic beads to move up and down in the separation column; therefore, the combination with cells in the sorting column is accelerated, and the cell sorting speed is increased.
Owner:JUNRUN BIOTECHNOLOGY (SHENZHEN) CO LTD

Battery pack cell module

This utility model discloses a battery pack cell module, relating to the field of battery pack manufacturing technology. It includes at least two sets of cell units. A T-shaped beam is provided at the top of the connection between the cell units, with the vertical beam of the T-shaped beam inserted downwards into the connection between the cell units. An insulating extruded T-shaped beam, conforming to the outer surface of the T-shaped beam and integrally formed, is provided between the cell unit and the T-shaped beam. A Z-shaped beam is provided at the bottom of the connection between the cell units, with the protrusion of the Z-shaped beam inserted upwards into the connection between the cell units. An insulating extruded Z-shaped beam, conforming to the outer surface of the Z-shaped beam and integrally formed, is provided between the cell unit and the Z-shaped beam. This utility model provides good insulation between the internal cell and the metal beam structure, effectively improving the safety and reliability of the battery pack cell module while increasing production efficiency.
Owner:柳州华霆新能源技术有限公司

Board structure, battery device, and electric device

The utility model discloses a plate structure, a battery device and a power utilization device, the plate structure comprises a first layer plate, a second layer plate and a third layer plate which are sequentially stacked along a first direction, and the second layer plate is a nylon particle foam plate. According to the plate structure, the nylon particle foam plate is clamped between the two layers of plates, the first layer of plate can disperse impact force, so that the foam plate is evenly stressed, the energy absorption characteristic is fully played, local failure is avoided, the internal foam structure of the nylon particle foam plate can effectively cope with impact, and the nylon particle foam plate is excellent in mechanical property, high in strength and high in toughness; when the foam board is impacted, energy is absorbed through foam hole deformation and nylon particle effect, the structure is kept stable, the third layer board provides supporting and restraining, excessive deformation of the foam board is prevented, and the integrity of the whole structure is guaranteed. The characteristics of the three layers of materials are complementary, an energy transfer path is optimized, the compression deformation capacity and the impact resistance capacity of the whole plate structure are greatly improved, structural safety and stability can be effectively guaranteed, the service life is prolonged, and the maintenance cost is reduced.
Owner:CONTEMPORARY AMPEREX INTELLIGENCE TECHNOLOGY (SHANGHAI) LTD

air bed

To provide an air bed which does not require a large storage space, can be made usable with a simple operation, and can provide high-quality sleep. [Solution] The device comprises an internal cell mat in which multiple rod-shaped cells made of soft film are connected horizontally with welded bars sandwiched between them, and an outer bag made of a breathable, low-elasticity material into which the internal cell mat is placed. The rod-shaped cells at both ends of the internal cell mat are larger in diameter than the rod-shaped cells between them, and the welded bars have non-welded sections in some parts so that the rod-shaped cells are connected to each other via the non-welded sections. When the internal cell mat is inflated with air and is not under load, the large-diameter rod-shaped cells at both ends come into contact with the use side and anti-use side of the outer bag, and the small-diameter rod-shaped cells between the large-diameter rod-shaped cells are not in contact with at least one of the use side or anti-use side of the outer bag, and the outer bag is in an expanded state in this state.
Owner:NICHIWA

Evaluating power consumption

A computer-implemented method for evaluating power consumption of an electronic circuit design including at least one logic gate is disclosed. The method includes receiving one or more data files describing an electronic circuit design, describing waveform data describing signal activity describing a logic gate used in the electronic circuit design, and describing power consumption values of internal cells of the logic gate of the electronic circuit design (701). Waveform data is extracted from one or more data files describing signal activity at a main input of the electronic circuit design and describing outputs of registers and memories of the electronic circuit design (702). Simulation of the logic gate is performed using the extracted waveform data to generate analog waveform data describing analog logic transitions of the internal cells of the logic gate (703), and event-based evaluation of power consumption of the electronic circuit design is performed based on the extracted waveform data, the analog waveform data, and the power consumption value (704).
Owner:SIMENS INDASTRI SOFTVEAR INK

Fuel cell, and method for manufacturing a fuel cell

This technology provides a way to suppress the deterioration of sealing performance. [Solution] The fuel cell cell comprises an anode separator and a cathode separator having a coating on their surface, and each of the anode separator and cathode separator comprises a main body, a coolant manifold which is an opening formed in the main body and through which coolant flows, an internal cell seal portion which seals the space between the anode separator and the cathode separator inside the fuel cell by the main body being bonded to an insulating sheet so as to surround the coolant manifold, and a sacrificial galvanic corrosion portion which is disposed between the coolant manifold and the internal cell seal portion and has a plurality of exposed portions in which the substrate is exposed without being covered by a coating, and the sacrificial galvanic corrosion portion has at least one exposed portion on a straight line connecting the coolant manifold and the internal cell seal portion.
Owner:TOYOTA JIDOSHA KK

Systems and methods for a battery cell odometer with internal resistance self-test

Systems and methods are disclosed herein for determining the remaining useful life of a battery cell that includes the battery cell's internal resistance and / or shock loading. In one example implementation, the systems and methods disclosed herein monitor acceleration information over time based on information received from an accelerometer integrated in a battery cell and electrical information for at least one electrical parameter of the battery cell over time. The information is stored for determining remaining useful life. In another example implementation, the systems and methods disclosed herein determine a voltage drop across the battery cell and a current output of the battery cell. The systems and methods determine an internal cell resistance of the battery cell based on charge or discharge voltage and current information.
Owner:KYMA BATTERIES LLC

Anti-tampering arrangement for computing device

An anti-tampering arrangement for a computing device including an intrusion detector configured to detect an infiltration of a printed circuit board of the computing device, a sensors layer including at least one sensor selected from the group consisting of a heat sensor configured to detect temperature changes indicative of tampering operations, a vibration sensor configured to detect vibrations associated with tampering operations, a light sensor configured to detect lighting variations indicative of tampering attempts, an internal cell sensor configured to detect tampering of a designated high security region of the computing device containing at least one highly sensitive component, and a device access sensor configured to detect unauthorized opening of a housing of the computing device, and a processor configured to monitor the intrusion detector and the sensors layer, and to trigger a security response upon detection of a tampering attempt.
Owner:ZEROPORT LTD

Embryo-like model and construction method and application thereof

PendingCN121752713ADrug screeningCulture processBiotechnologyModel disease
The invention provides a construction method of an embryo-like model, which comprises the following steps: culturing primitive state stem cells in vitro or injecting the primitive state stem cells into an immunodeficient animal body for differentiation to obtain the embryo-like model. According to the method, in the process of preparing the embryo-like model, cell factors and small molecular pathway interference factors do not need to be added, gene editing is not needed, only a single starting cell type is adopted, and the method has the advantages of being simple and high in repeatability, facilitates large-scale preparation and application, and has wide application prospects. And the prepared embryo-like model has all embryo external cell lineages and all embryo internal cell lineages except for trophoderm, and can simulate the development process from an implanted embryo of a Carbonate-resistant group 3 stage to a Carbonate-resistant group 9 stage nerve embryo, so that the embryo-like model can be used for preparing various progenitor cell lineages, modeling diseases, screening drugs and carrying out scientific research.
Owner:SHENZHEN HUADA GENE INST +1

A macro-micro mechanical property parameter prediction method for three-dimensional woven composite materials

The application discloses a kind of three-dimensional woven composite macro-mesoscopic mechanical property parameter prediction method, based on the internal real weaving structure of three-dimensional four-way woven composite material, the whole material is divided into surface area and internal area, and the periodic cell finite element model of two kinds of areas is respectively established, the nonlinear mechanical behavior characteristics of matrix material and yarn material are considered to carry out the explicit dynamics calculation of cell under different strain rates, to predict the mechanical property parameters of different regions of composite material under different strain rates, the strain rate strengthening parameter is obtained by curve fitting the mechanical property parameters under each strain rate.The mechanical property parameters of surface cell and internal cell area calculated by mesoscopic scale are respectively substituted into the surface cell area and internal cell area of macroscopic finite element model, so that high strain rate condition calculation such as ballistic impact, bird impact, ice impact and other impact dynamics related can be carried out.
Owner:NANJING UNIV OF AERONAUTICS & ASTRONAUTICS

Double-confinement heated sample holder, method for analyzing a sample using said sample holder.

PendingFR3170614A1Glass chipParticle physics
A double-confinement heated sample holder and a method for analyzing a sample using said sample holder. The invention relates to a sample holder (1) for analysis by X-ray scattering and / or X-ray spectroscopy, comprising: - an internal cell (3) including a cavity, configured to hermetically contain a sample to be analyzed, and windows opposite each other on either side of the cavity, each window being closed by a pane of glass transparent at least to X-rays; - a housing including at least one compartment, referred to as the first compartment (7), configured to hermetically contain the internal cell, and windows opposite each other on either side of the first compartment, each window being closed by a sheet transparent at least to X-rays; - at least one heating element (5) inserted in the housing so as to heat the cavity of the internal cell. Figure for the abstract: Fig. 3
Owner:COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES +3

Cell product quality analyzer

The invention relates to the field of detection equipment, in particular to a cell product quality analyzer. Comprising a shell, a control module, a cell test module, a lock-in amplifier and a display, and the control module is arranged in the shell; the control module is arranged in the shell, the cell testing module is arranged in the shell, the lock-in amplifier is arranged in the shell, the lock-in amplifier is electrically connected with the control module and the cell testing module, and the lock-in amplifier is used for extracting an impedance signal directly related to cell attributes from an electric signal output by the cell testing module; and then the extracted impedance signal is sent to the control module for processing. The micro-fluidic chip and the high-sensitivity lock-in amplifier are combined, a single cell is analyzed, a weak impedance change signal directly related to cell quality attributes is accurately extracted from a complex electric signal, and then the quality of the cell is detected based on a single type of detection signal. And synchronous detection of key quality attributes such as cell particle size, motility rate, apoptosis and heterogeneity is realized at the single cell level.
Owner:TIAN JIN KINSLY PHARMACEUTICAL R&D CO LTD

Fixing device for battery cell group in battery

The utility model relates to a fixing device for a battery cell group in a battery, and belongs to the technical field of batteries. The battery fixing device comprises a bottom plate, a first baffle and a second baffle, the bottom plate is used for supporting the whole battery, and the first baffle and the second baffle are both of an inverted L-shaped structure and are fixed to the bottom plate to form an enclosure frame structure to fix a battery cell set; meanwhile, the connecting piece is additionally arranged at the contact position of the first baffle and the second baffle, the two baffles are relatively fixed to form the enclosure frame by matching the connecting bolt with the connecting piece, and the structural stability is enhanced. In addition, the first baffle and the second baffle are each provided with at least one bottom plate fixing hole used for fixing the baffles, so that the baffles are fixed relative to the bottom plate. According to the utility model, the production cost is reduced, the cell mounting and dismounting process is convenient, no complex tool is needed, the structure is stable, the cell is not easy to loosen after long-term use, and the performance and safety of the battery are effectively guaranteed.
Owner:JIANGSU GUOXIA TECH CO LTD

Foamed silica gel production inspection method and system based on silicon matrix characteristic analysis

The invention discloses a foamed silica gel production inspection method and system based on silicon matrix characteristic analysis, and belongs to the technical field of high polymer material performance evaluation.The foamed silica gel product is subjected to three-dimensional structure scanning, internal foam structure data are obtained, and a foam three-dimensional structure model is established; extracting foam structure parameters based on the foam three-dimensional structure model, establishing a three-dimensional finite element model of the foamed silica gel material based on the foam structure parameters, and establishing a three-dimensional finite element model of the foamed silica gel material based on the foam structure parameters, applying a compression working condition and a stretching working condition corresponding to the actual use condition in the finite element model, performing finite element analysis on the foamed silica gel product to obtain an internal stress distribution state, and calculating a local stress concentration coefficient and an equivalent sealing performance index based on a finite element analysis result, and performance grading is performed on the foamed silica gel product based on the equivalent sealing performance index and the local stress concentration coefficient, and the dynamic sealing life is evaluated, so that the detection precision is improved.
Owner:NANJING PAKTAN SEALING SYST CO LTD

A centrifuge tube and assembly for making cell wax blocks

ActiveCN115646566BCell massMechanical engineering
The application discloses a centrifugal tube and assembly for making cell wax blocks. The centrifugal tube comprises a ball-sac-equipped inner thread top cover, a centrifugal tube body composed of a funnel part and a cell enrichment tube, a cell collection capsule, a bottom pad and a bottom-sealed inner thread cover. The cell collection capsule and the bottom pad are arranged inside the cell enrichment tube to collect cells and can be taken in and out of the lower opening of the cell enrichment tube. After installation, detection liquid is added to the centrifugal tube body, and the centrifugal tube body is centrifuged by a centrifugal machine. The cells in the liquid are settled in the collection capsule. The bottom thread cover is unscrewed, the ball sac is pressed, and the cell collection capsule with the internal cell sediment is discharged from the lower opening of the cell enrichment tube under the hydraulic action. Then, the cell collection capsule is taken with the capsule cap and is placed in 10% neutral formalin solution for fixation. The fixing solution gradually penetrates into the cell mass, and the cell sediment gradually forms a certain shape and hardness. In this way, the cell wax block is simple and convenient to make and is not limited by the small amount of cells.
Owner:王兆辉

Film thickness prediction method and system based on sequence angle spectrum analysis

The invention discloses a thin film thickness prediction method and system based on sequence angle spectrum analysis, and aims to solve the problem of insufficient measurement precision of complex multilayer films in a traditional method. The method comprises the following steps: acquiring optical reflectivity spectrums of a target film at a plurality of incident angles; arranging the spectrums into a sequence according to an angle sequence; inputting the sequence into a pre-trained long short-term memory (LSTM) network model; and the LSTM model updates the understanding of the film layer structure by utilizing internal cell state angle-by-angle accumulation, and finally outputs a film layer thickness prediction value. The system correspondingly comprises a data acquisition module, a sequence construction module and a prediction module. According to the method, the multi-angle optical response is constructed into the time series data, the deep physical correlation between the angles is captured by using the LSTM network, the limitation of a traditional ideal model is overcome, the precision, efficiency and robustness of predicting the thickness of the complex multi-layer thin film are remarkably improved, and an effective scheme is provided for industrial online detection.
Owner:SHANGHAI INST OF OPTICS & FINE MECHANICS CHINESE ACAD OF SCI

Systems and methods for a battery odometer with active shock and vibration monitoring

Systems and methods are disclosed herein for determining the remaining useful life of a battery cell that includes the battery cell's internal resistance and / or shock loading. In one example implementation, the systems and methods disclosed herein monitor acceleration information over time based on information received from an accelerometer integrated in a battery cell and electrical information for at least one electrical parameter of the battery cell over time. The information is stored for determining remaining useful life. In another example implementation, the systems and methods disclosed herein determine a voltage drop across the battery cell and a current output of the battery cell. The systems and methods determine an internal cell resistance of the battery cell based on charge or discharge voltage and current information.
Owner:KYMA BATTERIES LLC

Blastocyst transplantation outcome prediction method based on single image data

The invention discloses an embryo transplantation outcome prediction method based on single blastocyst image data, belongs to the field of medical artificial intelligence, and is suitable for single blastocyst transplantation. Firstly, a high-resolution embryo image of a patient is obtained. The image resolution is unified by fixing the aspect ratio of an original image and properly cutting and filling. A standard picture enhancement technology is adopted for model training, and adaptability to variable imaging conditions is improved. During prediction, a preprocessed image is input into a model which takes ResNet-50 as a trunk and combines SimCLR comparative learning to perform self-supervised pre-training, the model is used for extracting morphological features of embryos, and the recognition capability of the model for specific tasks is further optimized through supervised fine tuning. The extracted features are averagely pooled and then connected with a newly defined full-connection network, then pregnancy probability is output through a Sigmoid activation function, and finally a prediction result of single blastocyst transplantation is obtained through threshold mapping. Besides, in order to enhance clinical interpretability, gradient weighted class activation mapping (Grad-CAM) is further introduced, and a key region concerned by the model is visualized so as to verify whether the model is judged based on structures with biological significance, such as an internal cell mass and a trophoderm. According to the method, the transplantation outcome can be predicted under the condition of only depending on a single blastocyst image, and the method can be used for assisting clinical embryo selection and decision making.
Owner:NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV

A vibrating cell transfection microscopy observation platform

The application discloses a vibrating cell transfection microscopic observation platform, which comprises a sample loading module, a vibrating module and an observation module, wherein the sample loading module comprises a bottom plate and a sample stage installed on the bottom plate, and the vibrating module and the observation module are arranged on the bottom plate. The vibrating module comprises a driving motor and a sample table connected with the driving motor through an eccentric rotating shaft, and the sample table is used for placing a micro-fluidic chip. The module comprises a microscope tube, a high-speed camera assembled above an observation lens and a light source located below the observation lens. The driving motor rotates at a high speed, drives the sample table to make reciprocating motion through the eccentric rotating shaft, and makes the micro-fluidic chip move with the sample table; a suitable imaging focal plane is found by adjusting the height of the microscope tube; the light source illuminates the high-speed camera; and the high-speed camera collects signals to clearly record the flow channel morphology of the micro-fluidic chip and the internal cell motion state and trajectory, so that the accurate observation of the motion state of the cell micro-mechanical behavior is realized.
Owner:TSINGHUA UNIVERSITY