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Small-caliber composite multilayer artificial blood vessel and preparation method thereof

An artificial blood vessel and small-diameter technology, applied in the field of artificial blood vessels, can solve the problems of limited types of materials, high equipment requirements, and difficulty in meeting demands, and achieve the effects of convenient overall process, green preparation process, and high crystallinity

Active Publication Date: 2020-11-20
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the above methods can successfully prepare small-caliber composite multi-layer artificial blood vessels by combining multi-layer materials, and precisely control their micro-nano scale structure, the preparation process still faces high equipment requirements, limited material types and Time-consuming and other problems, it is difficult to meet the large demand of the market

Method used

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  • Small-caliber composite multilayer artificial blood vessel and preparation method thereof
  • Small-caliber composite multilayer artificial blood vessel and preparation method thereof
  • Small-caliber composite multilayer artificial blood vessel and preparation method thereof

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preparation example Construction

[0035] The invention provides a method for preparing a small-diameter composite multi-layer artificial blood vessel, comprising the following steps:

[0036] S1, dissolving chitosan and gelatin in an acidic solution, heating and stirring to make it fully dissolve, to obtain a chitosan / gelatin mixed solution;

[0037] S2, using the chitosan / gelatin mixed solution obtained in step S1 as an electrolyte, and construct a two-electrode system, and carry out electrophoretic deposition, so that the chitosan / gelatin composite gel is deposited on the surface of the needle electrode to form chitosan / gelatin composite gel coat;

[0038] S3. After washing the chitosan / gelatin composite gel coating obtained in step S2 and cooling it to room temperature, it is alternately soaked in sodium alginate solution and chitosan solution, using layer-by-layer self-assembly technology , forming a sodium alginate / chitosan gel layer on the outer surface of the chitosan / gelatin composite gel coating to o...

Embodiment 1

[0051] This embodiment provides a method for preparing a small-caliber composite multilayer artificial blood vessel, which includes the following steps:

[0052] S1. Dissolve chitosan and gelatin in hot water (85°C), adjust the pH to about 5 with hydrochloric acid, stir at 37°C to fully dissolve chitosan and gelatin, and prepare a mixture containing 1w / v% chitosan The chitosan / gelatin mixed solution of sugar and 0.5w / v% gelatin, does not contain NaCl or other salt ions in this chitosan / gelatin mixed solution;

[0053] S2, with the described chitosan / gelatin mixed solution that step S1 obtains as electrolytic solution, take platinum electrode as anode, and be the stainless steel needle electrode of 0.2mm as cathode with radius, the immersion depth of two electrodes is 1cm, spacing Electrophoretic deposition was carried out; the deposition voltage of electrophoretic deposition was set to 3V, the deposition temperature was 37°C, and the single deposition time was 1min. Continuous...

Embodiment 2～3

[0060] For further analyzing the performance of the chitosan / gelatin composite gel coating prepared by the electrophoretic deposition process provided by the present invention, embodiment 2~3 provides a kind of preparation method of chitosan / gelatin composite gel tube respectively, wherein , what implementation 2 prepared was the single-layer chitosan / gelatin composite gel tube, and what embodiment 3 prepared was the multilayer chitosan / gelatin composite gel tube.

[0061] Specifically, the preparation method of the monolayer chitosan / gelatin composite gel tube that embodiment 2 provides is as follows:

[0062] Prepare the chitosan / gelatin mixed solution containing 1w / v% chitosan and 1w / v% gelatin in the same manner as in Example 1 as the electrolyte; then the platinum wire electrode is the anode, and the radius is 0.2mm stainless steel The needle-shaped electrode is used as the cathode, and the immersion depth of the two electrodes is 1 cm, and the distance between the two el...

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Abstract

The invention discloses a small-caliber composite multilayer artificial blood vessel and a preparation method thereof. A chitosan / gelatin mixed solution is prepared as an electrolyte, and an electrophoretic deposition technology is utilized to deposit chitosan / gelatin composite gel on the surface of a needle-shaped electrode, so that a chitosan / gelatin composite gel coating is prepared; the composite gel coating is taken as a substrate, and a sodium alginate / chitosan outer layer is constructed on the surface of the composite gel coating by utilizing the layer-by-layer self-assembly effect to form chitosan / gelatin / sodium alginate composite multilayer gel; and after the composite multilayer gel is taken down, freeze drying is performed to obtain the chitosan / gelatin / sodium alginate compositemultilayer artificial blood vessel capable of simulating the special multilayer structure of the natural blood vessel. By means of the mode, the artificial blood vessel small in caliber and good in mechanical property can be rapidly and conveniently prepared; and the whole preparation process is easy to regulate and control, and the prepared composite multilayer artificial blood vessel is good inbiocompatibility, high in use safety and capable of meeting the requirements of practical application.

Description

technical field [0001] The invention relates to the technical field of artificial blood vessels, in particular to a small-diameter composite multilayer artificial blood vessel and a preparation method thereof. Background technique [0002] Artificial blood vessels are substitutes for many severely stenotic or occlusive blood vessels, and play an important role in the repair and treatment of cardiovascular diseases. At present, large and medium-caliber artificial blood vessels made of synthetic materials such as nylon, polyester, and polytetrafluoroethylene have been successfully used clinically and achieved satisfactory results. However, due to the slow blood flow and low blood pressure of small-caliber vessels, these synthetic materials It cannot support the adhesion and growth of endothelial cells, and does not have good compliance. It is easy to cause platelet accumulation, causing acute thrombosis, intimal hyperplasia and infection at the anastomosis, and it is difficult...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/26A61L27/50A61L27/20A61L27/54A61L27/22A61L27/56A61F2/06
CPCA61F2/06A61L27/507A61L27/26A61L27/20A61L27/56A61L27/54A61L27/222A61L2300/252A61L2300/42C08L5/08C08L5/04C08L89/00
Inventor 严坤徐飞扬王栋杨晨光李秀芳鲁振坦
Owner WUHAN TEXTILE UNIV
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