An apparatus for sealing a passage through tissue includes a plug including external threads, a lumen extending between its proximal and distal ends, and an annular 
collet slidably disposed within the lumen. The plug is carried on a distal end of a 
handle device that includes an inner member with a distal end that is slidable axially within the lumen of the body for moving the 
collet into a reduced cross-sectional region of the lumen, thereby compressing the 
collet to seal the lumen, and for deploying the plug from the 
handle device. During use, the plug is delivered into a passage through tissue over a guide wire. Once a desired location is reached, the plug is deployed from the 
handle device, thereby compressing the collet and sealing the lumen. The guide wire and handle device are removed, leaving the plug to seal the passage.