Preparation method of a novel biological decellularized implant material

An implant material and acellular technology, which is applied in the field of preparation of new biological acellular implant materials, can solve the problems of urethral stenosis and obstruction, poor anticoagulation of artificial blood vessels, zoonotic diseases, etc., and achieves good material histocompatibility. , Conducive to regeneration and repair, good biocompatibility

Active Publication Date: 2020-08-28
陈强
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, the common polymer medical devices have their own shortcomings in the use process, such as meningeal products have adhesion, leakage, poor adaptability to the brain surface, and easy to cause infection. Artificial urethra is easy to cause urethral stricture and obstruction. Poor coagulation, low long-term inflation rate, easy to cause vascular intimal hyperplasia, etc. Although animal-derived medical devices have more advantages in use and effect, they also have problems such as the risk of zoonotic diseases
[0009] At present, there is a lack of a new biological decellularized implant material with better biocompatibility that can replace the body's own tissues and some functions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of a novel biological decellularized implant material
  • Preparation method of a novel biological decellularized implant material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A preparation method of a novel biological decellularized implant material of the present invention, the novel biological decellularized implant material comprises the following steps:

[0034] (1) Raw material of the present invention: select the Ascaris suum alive less than 40cm in body length, male or female, should use within 3 hours after the death of the worm body;

[0035] (2) Pretreatment: After collecting the materials, kill them manually, then cut or dissect the insects according to the expected product, clean them with cleaning solution, and remove the contents of the body wall cavity as much as possible to obtain the required raw materials;

[0036] The cleaning solution is physiological saline.

[0037] (3) Material treatment: the processed roundworm body wall capsule is treated with surfactant and protease to obtain a biological scaffold with a three-dimensional structure;

[0038] The surfactant is triton-100, and the protease is a combination of pepsin ...

Embodiment 2

[0045] The difference between embodiment 2 and embodiment 1 is:

[0046] A preparation method of a novel biological decellularized implant material of the present invention, the novel biological decellularized implant material comprises the following steps:

[0047] In step (1), the raw material of the present invention: select live Ascaris suum with a body length less than 40cm, male or female, and use it within 1 hour after the death of the worm body;

[0048] In step (2), pretreatment: manually kill the material, then cut or dissect the worm body according to the expected product, clean it with a cleaning solution, remove the body wall cavity content as much as possible, and initially obtain the required raw materials;

[0049] The cleaning solution is a combination of physiological saline, sterilized water for injection and deionized water.

[0050] In step (3), material treatment: the processed ascarid body wall capsule is treated with surfactant and protease to obtain a...

Embodiment 3

[0057] The difference between embodiment 3 and embodiment 1 is:

[0058] A preparation method of a novel biological decellularized implant material of the present invention, the novel biological decellularized implant material comprises the following steps:

[0059] In step (1), raw material of the present invention: select body length as 38cm live Ascaris suum, male or female, should be used within 2 hours after the death of the worm body;

[0060] In step (2), pretreatment: manually kill the material, then cut or dissect the worm body according to the expected product, clean it with a cleaning solution, remove the body wall cavity content as much as possible, and initially obtain the required raw materials;

[0061] The cleaning solution is sterile water for injection.

[0062] In step (3), material treatment: the processed roundworm body wall capsule is treated with a surfactant and protease to obtain a biological scaffold with a three-dimensional structure; the surfactant...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
lengthaaaaaaaaaa
diameteraaaaaaaaaa
lengthaaaaaaaaaa
Login to view more

Abstract

The invention discloses a preparation method of a novel biological acellular implant material. The preparation method of the novel biological acellular implant material comprises the following steps: (1) carrying out raw material selection; (2) carrying out pretreatment; (3) carrying out material treatment; (4) carrying out material processing; and (5) storing the material finished product. According to the material disclosed by the invention, ascaris lumbricoides which can parasitize in the human body or the animal body are selected, the body wall bag of ascaris lumbricoide is taken as a raw material and is processed to prepare the biomedical material capable of being transplanted to the human body, the tissue compatibility of the material is good, and the material can replace the autologous tissue and partial functions of the human body.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a method for preparing a novel biological decellularized implant material. Background technique [0002] Surgery is the most common clinical treatment, and implantable medical devices play an indispensable role as a substitute for pathological tissues or organs. When abnormalities occur in human tissues or organs, operations such as clipping, ostomy, pressure limiting, support, hemostasis, shaping, and reconstruction of the diseased organ are usually required. At this time, a large number of medical device products are required. [0003] With the continuous improvement of clinical requirements for medical devices, the field of medical devices has also achieved great development in recent years, and various new implantable medical devices are emerging. At present, the raw materials of implantable medical devices have been used The earliest simple inorganic substances...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/50A61L15/42A61L15/40
CPCA61L15/40A61L15/42A61L27/3604A61L27/3675A61L27/3679A61L27/3687A61L27/507A61L2430/22A61L2430/32
Inventor 陈强贾敬亮陈有旺
Owner 陈强
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap