A small-diameter composite multi-layer artificial blood vessel and its preparation method
An artificial blood vessel and small-caliber technology, applied in the field of artificial blood vessels, can solve the problems of time-consuming, limited types of materials, high equipment requirements, etc., and achieve the effect of convenient and green preparation process
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[0035] The invention provides a method for preparing a small-diameter composite multi-layer artificial blood vessel, comprising the following steps:
[0036] S1, dissolving chitosan and gelatin in an acidic solution, heating and stirring to make it fully dissolve, to obtain a chitosan / gelatin mixed solution;
[0037] S2, using the chitosan / gelatin mixed solution obtained in step S1 as an electrolyte, and construct a two-electrode system, and carry out electrophoretic deposition, so that the chitosan / gelatin composite gel is deposited on the surface of the needle electrode to form chitosan / gelatin composite gel coat;
[0038] S3. After washing the chitosan / gelatin composite gel coating obtained in step S2 and cooling it to room temperature, it is alternately soaked in sodium alginate solution and chitosan solution, using layer-by-layer self-assembly technology , forming a sodium alginate / chitosan gel layer on the outer surface of the chitosan / gelatin composite gel coating to o...
Embodiment 1
[0051] This embodiment provides a method for preparing a small-caliber composite multilayer artificial blood vessel, which includes the following steps:
[0052] S1. Dissolve chitosan and gelatin in hot water (85°C), adjust the pH to about 5 with hydrochloric acid, stir at 37°C to fully dissolve chitosan and gelatin, and prepare a mixture containing 1w / v% chitosan The chitosan / gelatin mixed solution of sugar and 0.5w / v% gelatin, does not contain NaCl or other salt ions in this chitosan / gelatin mixed solution;
[0053] S2, with the described chitosan / gelatin mixed solution that step S1 obtains as electrolytic solution, take platinum electrode as anode, and be the stainless steel needle electrode of 0.2mm as cathode with radius, the immersion depth of two electrodes is 1cm, spacing Electrophoretic deposition was carried out; the deposition voltage of electrophoretic deposition was set to 3V, the deposition temperature was 37°C, and the single deposition time was 1min. Continuous...
Embodiment 2~3
[0060] For further analyzing the performance of the chitosan / gelatin composite gel coating prepared by the electrophoretic deposition process provided by the present invention, embodiment 2~3 provides a kind of preparation method of chitosan / gelatin composite gel tube respectively, wherein , what implementation 2 prepared was the single-layer chitosan / gelatin composite gel tube, and what embodiment 3 prepared was the multilayer chitosan / gelatin composite gel tube.
[0061] Specifically, the preparation method of the monolayer chitosan / gelatin composite gel tube that embodiment 2 provides is as follows:
[0062] Prepare the chitosan / gelatin mixed solution containing 1w / v% chitosan and 1w / v% gelatin in the same manner as in Example 1 as the electrolyte; then the platinum wire electrode is the anode, and the radius is 0.2mm stainless steel The needle-shaped electrode is used as the cathode, and the immersion depth of the two electrodes is 1 cm, and the distance between the two el...
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