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Medical internal marmem frame coated by high-molecular film for penetration therapy and its preparing process

A memory alloy and internal stent technology, applied in the field of biomedical engineering, can solve the problems of poor biocompatibility, easy thrombosis, poor biocompatibility of metal stents, etc.

Inactive Publication Date: 2002-12-04
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor biocompatibility of the metal stent, and the diseased tissue can grow into the cavity through the mesh, it is necessary to coat the metal stent with a film.
Currently used membranes are prone to thrombosis due to poor biocompatibility

Method used

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  • Medical internal marmem frame coated by high-molecular film for penetration therapy and its preparing process
  • Medical internal marmem frame coated by high-molecular film for penetration therapy and its preparing process
  • Medical internal marmem frame coated by high-molecular film for penetration therapy and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] endometrial manufacture, such as figure 1 Shown is a stent covered with intima, and its production method is as follows: use soft polyethylene film to wrap the surface of the metal alloy stent (when wrapping, try to be as flat as possible to ensure the flatness of the formed intima), heat it slightly The film hardens. Then put 0.1 g / ml polyurethane tetrahydrofuran solution inside the bracket, and rotate the bracket to volatilize the solvent to form a film (just at room temperature). The motorized device shown in Figure 3 can be used for film formation, and the entire bracket is placed inside the sleeve, and the motor drives the rotation. After the polymer film is fully set (generally, the solvent can be fully developed for 3 to 4 hours at room temperature), the polyethylene film can be peeled off. The intima formed by this method has good uniformity, is solidly integrated with the metal stent, and has relatively strong impact resistance, which ensures that the membran...

Embodiment 2

[0026] For the manufacture of the outer membrane, we adopt the process of film formation and membrane separation. First, prepare the sleeve of the outer membrane according to the size of the metal alloy stent (the outer membrane mold cylinder is not adhered to the polyurethane membrane). The device puts 0.1g / ml polyurethane tetrahydrofuran solution in the outer membrane sleeve, and rotates the sleeve to volatilize the solvent to form a film. The resulting outer membrane is removed, and then the outer membrane is bonded to the fulcrum of the alloy stent by using saturated polyurethane solution as an adhesive. When bonding, attention should be paid to taking more bonding points at both ends of the adventitia to improve the firmness of the adhesion between the adventitia and the stent. (See figure 2 )

Embodiment 3

[0028] To manufacture the microporous inner membrane, we add an appropriate amount of sieved pore-forming agent to the 0.1g / ml polyurethane solution (salt is used as the pore-forming agent in this example, and the specific sieving size depends on the micropore requirements for medical use. Examples employ 100 micron sieves). Experiments show that when the salt concentration is 0.06-0.07g / ml, the microporous membrane has a better porosity and does not affect the strength requirement of the membrane. The specific process of forming an inner film is similar to that of Example 1. Finally, wash away the salt grains on the stent that formed the intima with warm water.

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Abstract

A high-molecular film covering on the surface of medical internal marmem supporter for insertion therapy is composed of internal, external and miniporous films. The said supporter has better elasticity, biological compatibility and medicine carrying power. It is used for esophagus, trachea, blood vessel, biliary trace and urethra.

Description

technical field [0001] The invention relates to a memory alloy medical inner stent polymer coating, which belongs to the field of biomedical engineering. Background technique [0002] Interventional therapy is a method of using a catheter to deliver drugs or surgical instruments to the lesion for treatment. One of the important application methods is to introduce a highly elastic metal alloy mesh stent into the lesion. The metal stent can be applied to the esophagus, Interventional therapy for trachea, blood vessels, biliary tract, urethra and other parts. However, because the biocompatibility of the metal stent is not good, and the diseased tissue can grow into the cavity through the mesh, it is necessary to coat the metal stent with a film. Currently used membranes are prone to thrombosis due to their poor biocompatibility. Contents of the invention [0003] The purpose of the present invention is to provide a film material with good biocompatibility, good elasticity a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/00A61F2/04A61L27/34A61M29/00
Inventor 胡平徐瀚熊强
Owner TSINGHUA UNIV
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