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Medicament coating material and preparation method

A drug coating and drug technology, applied in coating, medical science, prosthesis, etc., can solve the problem of inhibition of vascular re-endothelialization process, and achieve the effect of protecting vascular endothelial cells, increasing drug concentration, and inhibiting cholesterol synthesis.

Inactive Publication Date: 2011-01-05
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a drug coating material and preparation method that can be applied to vascular tissue engineering and interventional stents to solve the problems in the prior art that the re-endothelialization process of blood vessels after stenting is inhibited. Material is degradable, promotes endothelial cell growth and inhibits platelet adhesion

Method used

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  • Medicament coating material and preparation method
  • Medicament coating material and preparation method
  • Medicament coating material and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The drug is ferulic acid, and the drug carrier is a copolymer of hydroxybutyrate and hydroxycaproate (molecular weight: 200000; the molar percentage of hydroxycaproate is 12%), and the weight ratio is 1:20.

[0031] In this embodiment, the specific steps of the preparation method of the drug coating material are as follows:

[0032] (1) dissolving the drug and the drug carrier in ethyl acetate, and after being ultrasonically and uniformly dissolved, a drug coating material solution is obtained, and the concentration of the drug coating material solution is 5wt%;

[0033] (2) The drug coating material is prepared by solution casting method. The uniformly dissolved drug coating material solution is poured into a glass vessel, and the solvent is evaporated under vacuum at 25°C for 24 hours to form a film, and then heated to 35°C. Thoroughly evaporate the solvent for 48 hours, and then use it after sterilization.

Embodiment 2

[0035] The drug is ferulic acid, and the drug carrier is a copolymer of hydroxybutyrate and hydroxycaproate (molecular weight: 200000; the molar percentage of hydroxycaproate is 12%), and the weight ratio is 1:10.

[0036] In this embodiment, the specific steps of the preparation method of the drug coating material are as follows:

[0037] (1) dissolving the drug and the drug carrier in ethyl acetate, and after being ultrasonically and uniformly dissolved, a drug coating material solution is obtained, and the concentration of the drug coating material solution is 10wt%;

[0038] (2) The drug coating material is prepared by solution casting method. The uniformly dissolved drug coating material solution is poured into a glass vessel, and the solvent is evaporated under vacuum at 25°C for 24 hours to form a film, and then heated to 35°C. Thoroughly evaporate the solvent for 48 hours, and then use it after sterilization.

Embodiment 3

[0040] According to Example 1, the drug-loaded coating was prepared for in vitro platelet adhesion test. like figure 1 As shown, the test results prove that the number of adhered platelets on the surface of the drug-loaded coating and the non-medicated coating is relatively small after 0.5 hours of contact with plasma. After 3 hours of contact with plasma, the number of surface-attached platelets increased. However, compared with the non-drug-loaded coating, the number of platelets adhered to the surface of the drug-loaded coating and the degree of platelet aggregation and deformation are smaller, indicating that the drug-loaded coating can effectively inhibit the adhesion of platelets on the coating. and activate.

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Abstract

The invention relates to the field of vascular tissue engineering, in particular to a medicament coating material which can be used in vascular tissue engineering and intervened in a stent and a preparation method. The coating material has the characteristics of degradability and an effect on promoting the growth of endothelial cells and inhibiting platelet adhesion. The coating material takes a polymer material which has good biocompatibility as a medicament carrier, and takes an effective extracts such as ferulic acid and derivatives thereof of a traditional Chinese medicament angelica sinensis. The preparation method has the following processes of: fully dissolving the medicament carrier and a medicament with a solvent; and using after mixing uniformly by ultrasonic sound. The medicament coating material can be prepared by a solution pouring method, wherein uniformly dissolved solution is poured in glass ware; volatilizing the solvent for 24 hours at the temperature of between 20 and 25 DEG C in vacuum to form a film; continuing heating for volatilizing the solvent thoroughly for 48 hours; and sterilizing for later use. The coating material has the effects on inhibiting the platelet adhesion and prompting the growth of endothelial cells, and can be used in the field of vascular tissue engineering and intervened in a degradable medicament coating on a stent surface.

Description

technical field [0001] The invention relates to the field of vascular tissue engineering, in particular to a drug coating material using ferulic acid and its derivatives, an effective extract of Angelica sinensis, a traditional Chinese medicine, as a drug, and a biodegradable polymer as a drug carrier, and a preparation method thereof. Background technique [0002] Percutaneous coronary intervention (PCI) is currently one of the main methods for the treatment of coronary heart disease. Postoperative restenosis severely limits the long-term effect and is the main problem that plagues coronary heart disease interventional therapy. The mechanism of restenosis mainly includes vascular elastic recoil, thrombus formation, neointimal hyperplasia and vascular remodeling. Intracoronary stents supplemented with effective new antiplatelet drugs have largely solved the problems of elastic recoil, vascular remodeling and thrombus, but neointimal hyperplasia has become the main cause of i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/28A61L27/54A61L27/18
Inventor 张二林申峰
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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