2results about How to "Small systemic side effects" patented technology

The present application provides an intervertebral fusion cage, which comprises an upper support plate, a lower support plate arranged in a height direction and below the upper support plate, and a drug releasing part connected between the upper support plate and the lower support plate, wherein the drug releasing part comprises a drug storage part, and when the upper support plate and the lower support plate are pressed, the drug in the drug storage part is squeezed out. The intervertebral fusion cage of the present application realizes micro-targeted drug delivery triggered by activity, precise inhibition of local inflammation and significant reduction of systemic side effects by arranging the drug releasing part comprising the drug storage part.

This invention provides a composite hydrogel biomimetic scaffold and its preparation method. The method includes preparing a phenylboronic acid-modified chitosan and hyaluronic acid solution; preparing carboxylated polyvinyl alcohol; preparing the two into a polyvinyl alcohol-chitosan-hyaluronic acid hydrogel; adding an anti-ferroptosis drug and an anti-P2X4 receptor drug to the polyvinyl alcohol-chitosan-hyaluronic acid hydrogel to obtain a drug-loaded composite hydrogel; preparing a hybrid material with a bio-glass sheet; and fabricating the hybrid material into a biomimetic scaffold using 3D printing. Through dynamic borate ester bonds as crosslinking and responsive units, the biomimetic scaffold can achieve rapid release of the loaded drug. By adding an anti-ferroptosis drug and an anti-P2X4 receptor drug, it synergistically addresses the intertwined pathological states of oxidative stress, ferroptosis, and neuropathic pain after nerve injury through three key pathways: inhibiting lipid peroxidation, chelating free iron, and blocking purine receptor-mediated neuroinflammation.