7results about How to "Small systemic side effects" patented technology

The invention relates to the technical field of nano biological medicines, and discloses a photo-thermal-enzyme catalysis nano-particle as well as a preparation method and application thereof. The photo-thermal-enzyme catalysis nano-particles are constructed by crosslinking water-soluble self-doped polyaniline nano-particles, human serum albumin, lactate oxidase and collagenase through a thioacetal linker capable of being split by active oxygen. Collagenase and lactate oxidase (LOx) are integrated into the same nanoparticle system through a thioacetal (TK) linker, the TK linker is split under the action of tumor microenvironment active oxygen (ROS) and H2O2 generated by catalysis of the LOx, the activity of the two enzymes is synchronously activated, a collagen matrix (physical barrier) is degraded, lactic acid (chemical barrier) is removed, the tumor microenvironment is efficiently remodeled, and the tumor microenvironment can be effectively inhibited. The problems that the regulation effect of a single barrier is limited, and the tumor microenvironment is difficult to improve are solved.

The present application provides an intervertebral fusion cage, which comprises an upper support plate, a lower support plate arranged in a height direction and below the upper support plate, and a drug releasing part connected between the upper support plate and the lower support plate, wherein the drug releasing part comprises a drug storage part, and when the upper support plate and the lower support plate are pressed, the drug in the drug storage part is squeezed out. The intervertebral fusion cage of the present application realizes micro-targeted drug delivery triggered by activity, precise inhibition of local inflammation and significant reduction of systemic side effects by arranging the drug releasing part comprising the drug storage part.

The application provides a low-pressure drug-loaded balloon catheter system for preoperative treatment of abdominal aortic aneurysm endovascular repair and a pre-treatment method, which comprises a catheter main body, a segmented balloon structure is arranged at the distal end of the catheter main body, a drug-loaded coating structure for realizing biological remodeling of the abdominal aortic aneurysm lesion vessel wall is arranged on the outer surface of the segmented balloon structure, the drug-loaded coating structure releases active drugs for inhibiting the pathological progression of abdominal aortic aneurysm under the action of blood flow, a pressure control system in communication with the segmented balloon structure is arranged on the catheter main body, and the pressure control system is used for low-pressure inflation of the segmented balloon structure and adjustment of injection pressure and flow rate. The application improves the local drug delivery efficiency under the premise of ensuring operation safety through the synergistic design of structural design and drug delivery mechanism, and provides a new preoperative intervention strategy for the treatment of abdominal aortic aneurysm.

The invention discloses a fusion polypeptide RAT-1 and application thereof in hypertension treatment. The topological structure of the fusion polypeptide is a kidney targeting head-ACE2 functional segment-MMP responsive connexon-AT1 receptor antagonism segment, and the full-length sequence is as shown in SEQ ID No: 1. The kidney targeting head can be specifically combined with megalin receptors of renal tubular epithelial cells to realize kidney targeting delivery; the ACE2 functional segment can efficiently degrade angiotensin II; the MMP responsive connexon is specifically cut in a focus microenvironment, and an AT1 receptor antagonism segment is released; the AT1 receptor antagonist segment can block the receptor signal channel of angiotensin II. The fusion polypeptide has good plasma stability, shows a powerful and long-acting antihypertensive effect in a spontaneous hypertension rat model, is remarkable in kidney targeting, and can relieve renal fibrosis and protect podocyte functions. The fusion polypeptide disclosed by the invention realizes a synergistic effect of targeted delivery, enzymolysis catalysis, response release and receptor antagonism, and can be used for preparing hypertension treatment medicines and kidney protection medicines.

The invention discloses a polycarbonate material adjuvant and a preparation method and application thereof, and belongs to the technical field of biological medicine and immunotherapy, the polycarbonate material adjuvant comprises a biodegradable polycarbonate polymer chain segment; the STING agonist is covalently linked to a side chain of a chain segment of the polycarbonate polymer through an amido bond; based on the design thought of degradable polymer-drug coupling, the polycarbonate material adjuvant is slowly hydrolyzed under the action of in-vivo enzyme to release an STING agonist, so that continuous activation of an immune pathway is realized. According to the invention, the STING agonist is combined with the polycarbonate polymer chain segment, so that the continuous activation of the STING pathway is realized, and the cellular immune response is obviously enhanced. The polycarbonate material adjuvant can be gradually hydrolyzed and released in vivo, so that the utilization rate of the medicine in local and drainage lymph nodes is improved, meanwhile, the polycarbonate material adjuvant has good biocompatibility and safety, and a new solution is provided for immunological enhancement of rabies vaccines.

This invention provides a composite hydrogel biomimetic scaffold and its preparation method. The method includes preparing a phenylboronic acid-modified chitosan and hyaluronic acid solution; preparing carboxylated polyvinyl alcohol; preparing the two into a polyvinyl alcohol-chitosan-hyaluronic acid hydrogel; adding an anti-ferroptosis drug and an anti-P2X4 receptor drug to the polyvinyl alcohol-chitosan-hyaluronic acid hydrogel to obtain a drug-loaded composite hydrogel; preparing a hybrid material with a bio-glass sheet; and fabricating the hybrid material into a biomimetic scaffold using 3D printing. Through dynamic borate ester bonds as crosslinking and responsive units, the biomimetic scaffold can achieve rapid release of the loaded drug. By adding an anti-ferroptosis drug and an anti-P2X4 receptor drug, it synergistically addresses the intertwined pathological states of oxidative stress, ferroptosis, and neuropathic pain after nerve injury through three key pathways: inhibiting lipid peroxidation, chelating free iron, and blocking purine receptor-mediated neuroinflammation.

The invention provides an interbody fusion cage which comprises an upper supporting plate, a lower supporting plate and a medicine release part, the lower supporting plate and the upper supporting plate are arranged in a spaced mode in the height direction, the lower supporting plate is located below the upper supporting plate, the medicine release part is connected between the upper supporting plate and the lower supporting plate, and the medicine release part comprises a medicine bin used for storing medicine. When the upper supporting plate and the lower supporting plate are squeezed, the medicine in the medicine bin is squeezed out. According to the interbody fusion cage disclosed by the invention, by arranging the medicine release piece comprising the medicine bin, trace and targeted medicine delivery triggered by movement is realized, local inflammation is accurately inhibited, and side effects of the whole body are greatly reduced.