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Oral tumor resistant pH sensitive intelligent material and application thereof

An oral tumor and smart material technology, applied in the field of pH-sensitive smart materials for anti-oral tumors, can solve the problems of large systemic side effects and low local efficacy, and achieve the goal of small systemic side effects, high local effects, and promoting the apoptosis of oral squamous cell carcinoma. Effect

Inactive Publication Date: 2021-10-22
SICHUAN UNIV
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  • Abstract
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Problems solved by technology

[0006] The existing anti-oral tumor chemotherapy drugs have large systemic side effects, low local efficacy, and do not respond to the specific microenvironment of the tumor

Method used

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  • Oral tumor resistant pH sensitive intelligent material and application thereof
  • Oral tumor resistant pH sensitive intelligent material and application thereof
  • Oral tumor resistant pH sensitive intelligent material and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The pH-sensitive smart material used in the present invention is a tertiary ammonium monomer, methyldodecylaminoethyl methacrylate (DMAEM).

[0031] 1. Biosafety testing of tertiary ammonium

[0032] The cells used in this part are human oral keratinocytes (Human Oral Keratinocytes, HOK), cultured in DMEM high glucose medium (Dulbecco’s modified Eagle Medium, gibco). The biosafety of the material was evaluated based on the effect of tertiary ammonium on the growth of HOK cells.

[0033] Inoculate 1x10 in a 96-well plate 4 HOK cells in 5% CO 2 Incubate overnight at 37°C in a cell culture incubator. After the cells adhered to the wall, the original medium was aspirated, and 100 μL of fresh DMEM medium containing different concentrations of tertiary ammonium (0–100 μg / mL) was added, and incubated in a 37°C cell culture incubator. Each group has 6 replicate wells.

[0034] After 24 h, the CCK8 kit (APExBIO) was used to detect cell proliferation toxicity. The specific ...

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Abstract

The invention belongs to the technical field of oral tumor resistance, and discloses an oral tumor resistant pH sensitive intelligent material and an application thereof; the oral tumor resistant pH sensitive intelligent material is a tertiary ammonium monomer, and the tertiary ammonium monomer is methylacrylic acid methyl dodecyl amino ethyl ester, namely DMAEM. The invention provides the application of the oral tumor resistant pH sensitive intelligent material in drugs for inhibiting growth of oral squamous cell carcinoma cells, inhibiting tumor growth caused by the oral squamous cell carcinoma cells and preventing or treating the oral squamous cell carcinoma. The oral tumor resistant pH sensitive intelligent material provided by the invention can inhibit proliferation of tumor oral squamous cell carcinoma cells and promote apoptosis of oral squamous cell carcinoma under a biosafety concentration; and in addition, the material has a pH sensitive property, and the proliferation inhibiting and apoptosis promoting effects of the material are enhanced in an acid environment, namely an environment with the pH being 6.7. Animal experiments prove that the material has anti-tumor performance.

Description

technical field [0001] The invention belongs to the technical field of anti-oral tumors, and in particular relates to a pH-sensitive intelligent material for anti-oral tumors and an application thereof. Background technique [0002] At present: Oral tumors are one of the top ten common cancers, which seriously affect patients' eating, chewing, speech, and appearance, seriously affect the quality of life of patients, and are life-threatening. Among them, oral squamous cell carcinoma has the highest incidence rate, and more than 90% of oral malignant tumors are squamous cell carcinoma. In recent years, the prevention and treatment of oral squamous cell carcinoma has been extensively studied. However, the recurrence rate is high, and its five-year survival rate is only about 60%. The treatment of oral squamous cell carcinoma is mainly based on multimodal combination therapy, which consists of surgical resection combined with radiotherapy and chemotherapy or comprehensive trea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C213/02C07C219/08A61P35/00A61P1/02
CPCC07C213/00C07C213/02C07C219/08A61P35/00A61P1/02C07C215/08
Inventor 程磊刘诗雨李博磊郝渝韩琪周学东
Owner SICHUAN UNIV
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