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Hericium erinaceus polysaccharide chelated zinc microcapsule and preparation method thereof

A technology of Hericium erinaceus polysaccharide and chelated zinc, applied in the directions of microcapsules, capsule delivery, drug combination, etc., can solve the problems of low zinc content, prolonged shelf life, poor antioxidant activity, etc., and achieve the improvement of antioxidant effect. , the effect of prolonging the shelf life and wide practical value

Active Publication Date: 2019-07-26
CHANGSHU INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The object of the present invention is to provide a kind of Hericium erinaceus polysaccharide chelated zinc microcapsule and preparation method thereof, the present invention is raw material with Hericium erinaceus polysaccharide, and it is chelated with zinc ion to form polysaccharide zinc chelate, in taking karaage Glue: Chitosan: β-cyclodextrin as the wall material, after homogeneous emulsification and spray drying, and microencapsulation treatment, the chelated zinc microcapsules of Hericium erinaceus polysaccharides are prepared, which overcomes the traditional anti-oxidation effect of Hericium erinaceus polysaccharides. The problem of poor activity and low zinc content in Hericium erinaceus polysaccharide chelated zinc (Zn-HEP) can not only improve its dispersibility and emulsification dispersibility, but also protect the easily oxidizable components in the polysaccharide and enhance its stability and antioxidant activity, prolong shelf life, and the prepared Hericium erinaceus polysaccharide chelated zinc microcapsules have obvious antioxidant activity, enhance immune function and anticancer effect, the preparation method is simple and convenient, can realize industrial continuous production, and has a wide range of applications Practical value

Method used

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  • Hericium erinaceus polysaccharide chelated zinc microcapsule and preparation method thereof
  • Hericium erinaceus polysaccharide chelated zinc microcapsule and preparation method thereof
  • Hericium erinaceus polysaccharide chelated zinc microcapsule and preparation method thereof

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Embodiment 1

[0045] Example 1: Preparation of Hericium erinaceus polysaccharide chelated zinc microcapsules

[0046] The invention provides a preparation method of Hericium erinaceus polysaccharide chelated zinc microcapsules, which specifically adopts the following technical steps:

[0047] (1) Preparation of Hericium erinaceus polysaccharide chelated zinc (Zn-HEP): configuration concentration is 12.5g / L-17.5g / L Hericium erinaceus polysaccharide solution, gets 20mL-30mL polysaccharide solution, adds 20mL-30mL concentration to be 0.4mol / L-0.5mol / L ZnSO 4 Solution, stirred and reacted at 30°C-50°C for 2h-4h, the reaction solution was dialyzed through running water for 7h-9h, and dried to obtain Hericium erinaceus polysaccharide chelated zinc (Zn-HEP), the zinc content was 4mg / g-6mg / g.

[0048] (2) Preparation of Hericium erinaceus polysaccharide chelated zinc microcapsules: Carrageenan, chitosan and β-cyclodextrin are used as wall materials, the core-to-wall ratio is 1:9-1:11, and the so...

Embodiment 2

[0056] Embodiment two: the preparation of Hericium erinaceus polysaccharide (HEP)

[0057] The purchased Hericium erinaceus is dried, crushed, and passed through a 60-mesh sieve to obtain dried Hericium erinaceus powder. Extract Hericium erinaceus powder and distilled water in hot water at 90°C for 3 hours at a solid-liquid ratio of 1:30. The extract was centrifuged at 4000r / min for 10min, the precipitate was discarded and the supernatant was combined. The combined supernatant was rotary evaporated to 1 / 3 of the original volume, and 4 times the volume of 95% ethanol was added to precipitate overnight, and the precipitate was collected after centrifugation. After drying, it was Hericium erinaceus crude polysaccharide (HEP).

[0058] Reconstitute the dried HEP with distilled water to remove protein, add Sevage reagent (n-butanol: chloroform = 1:4) to 1 / 4 volume of the concentrated liquid, stir at room temperature for 20 min, centrifuge at 2600 r / min, and combine supernatant. ...

Embodiment 3

[0060] Embodiment three: the preparation of Hericium erinaceus polysaccharide chelated zinc (Zn-HEP)

[0061] Configure the Hericium erinaceus polysaccharide solution with a concentration of 7.5g / L, take 35mL of the polysaccharide solution, add 30mL of ZnSO with a concentration of 0.35mol / L 4 The solution was stirred and reacted at 30°C for 6h. The reaction solution was dialyzed under running water for 6 hours, and then dried to obtain the chelated zinc of Hericium erinaceus polysaccharide (Zn-HEP).

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Abstract

The invention discloses a hericium erinaceus polysaccharide chelated zinc microcapsule and a preparation method thereof. The method includes utilizing a hericium erinaceus polysaccharide as a raw material, chelating the hericium erinaceus polysaccharide with zinc ions to form a polysaccharide zinc chelate, performing homogenization emulsification and spray drying with carrageenan: chitosan: beta-cyclodextrin as wall materials and performing microencapsulation treatment to obtain the hericium erinaceus polysaccharide chelated zinc microcapsule. The microcapsule overcomes shortcomings of poor antioxidant activity of the traditional hericium erinaceus polysaccharide and low zinc content in the hericium erinaceus polysaccharide chelated zinc (Zn-HEP), can not only improve the dispersibility and the emulsifying dispersibility, but also protect the easily oxidized components in the polysaccharide, enhance stability and antioxidant activity and prolong the shelf life. The prepared hericium erinaceus polysaccharide chelated zinc microcapsule has obvious anti-oxidation activity, and enhances immune function and anti-cancer effect. The preparation method is simple and convenient, capable ofachieving industrial continuous production, and has wide practical value.

Description

technical field [0001] The invention belongs to the field of polysaccharide extraction and preparation, specifically, the invention belongs to the technical field of Hericium erinaceus polysaccharide chelated zinc microcapsules and a preparation method thereof. Background technique [0002] Hericium erinaceus, also known as Hericium erinaceus, belongs to Hericiaceae (Hericiaceae) and the genus Hericium erinaceus. It is a precious edible fungus growing in dense forests, and it is also a traditional medicinal and food material. . Hericium erinaceus is white when fresh, and light yellow or light brown after drying. In my country, Hericium erinaceus produced in Xiaoxing'an Mountains and Wanda Mountain in Heilongjiang is the most famous. At present, due to the development of artificial cultivation technology, Hericium erinaceus is cultivated all over the country. [0003] Hericium erinaceupopolysaccharides (HEP) is an important active substance in the fruiting body of Hericium ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/715A61K47/36A61K47/40A61P35/00A61P37/04A61P39/06
CPCA61K9/5036A61K9/5089A61K31/715A61P35/00A61P37/04A61P39/06
Inventor 陈义勇冀宏薛依婷高荣张泽徐紫依张子轶丁霄吴欣怡蒋晗
Owner CHANGSHU INSTITUTE OF TECHNOLOGY
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