Mesoporous metal organic framework as well as preparation method and application thereof

A metal-organic framework and mesoporous technology, applied in the direction of organic active ingredients, medical preparations of non-active ingredients, medical preparations containing active ingredients, etc., to achieve good biodegradability, promote Fenton reaction efficiency, and good photothermal effect of effect

Active Publication Date: 2020-11-10
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these studies all induced ferroptosis by the photosensitizer producing ROS and the GPX-4 inhibitor sorafenib

Method used

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  • Mesoporous metal organic framework as well as preparation method and application thereof
  • Mesoporous metal organic framework as well as preparation method and application thereof
  • Mesoporous metal organic framework as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1: A method for preparing a mesoporous metal organic framework:

[0054] (1) Take N,N-dimethylformamide and absolute ethanol, and prepare a composite solution whose volume ratio is 5:3;

[0055] (2) get the composite solution that step (1) makes to prepare respectively the FeCl that contains mass concentration and is 100mg / mL 2 solution, containing CuCl with a mass concentration of 100mg / mL 2 solution and a dithioglycolic acid solution containing a mass concentration of 50 mg / mL were ultrasonically dissolved respectively;

[0056] (3) FeCl prepared in step (2) 2 solution and CuCl 2 solution according to Fe 2+ and Cu 2+ Add the molar ratio of 1:1 to a 15mL centrifuge tube, then add 0.1mL of dithioglycolic acid solution, 250mg of PVP and 100μL of TEA, use the compound solution in step (1) to dilute to 15mL, and ultrasonically dissolve , placed in a high-pressure reactor, and reacted at 150°C for 24h;

[0057] (4) The reactant in step (3) was left to cool at...

Embodiment 2

[0058] Example 2: A preparation method of a mesoporous metal organic framework:

[0059] (1) Take N,N-dimethylformamide and absolute ethanol, and prepare a composite solution whose volume ratio is 3:2;

[0060] (2) get the composite solution that step (1) makes to prepare the FeCl that contains mass concentration respectively and be 200mg / mL 2 solution, containing CuCl with a mass concentration of 100mg / mL 2 solution and a selenocysteine ​​solution containing a mass concentration of 50 mg / mL were ultrasonically dissolved, respectively;

[0061] (3) FeCl prepared in step (2) 2 solution and CuCl 2 solution according to Fe 2+ and Cu 2+ Add the molar ratio of 2:1 to a 15mL centrifuge tube, then add 0.1mL of selenocysteine ​​solution, 300mg of PVP and 200μL of TEA, use the compound solution in step (1) to make up to 15mL, and ultrasonically dissolve , placed in a high-pressure reactor, and reacted at 135°C for 24h;

[0062] (4) The reactant in step (3) was left to cool at ro...

Embodiment 3

[0063] Example 3: A method for preparing a mesoporous metal organic framework:

[0064] (1) Take N,N-dimethylformamide and absolute ethanol, and prepare a composite solution whose volume ratio is 5:3;

[0065] (2) get the composite solution that step (1) makes to prepare respectively the FeCl that contains mass concentration and is 150mg / mL 2 solution, containing CuCl with a mass concentration of 200mg / mL 2 solution and a dithioglycolic acid solution containing a mass concentration of 50 mg / mL were ultrasonically dissolved respectively;

[0066] (3) FeCl prepared in step (2) 2 solution and CuCl 2 solution according to Fe 2+ and Cu 2+ Add the molar ratio of 11:4 to a 15mL centrifuge tube, then add 0.1mL of dithioglycolic acid solution, 200mg of PVP and 80μL of TEA, use the compound solution in step (1) to dilute to 15mL, and ultrasonically dissolve , placed in a high-pressure reactor, and reacted at 150°C for 24h;

[0067] (4) The reactant in step (3) was left to cool at...

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Abstract

The invention provides a mesoporous metal organic framework as well as a preparation method and application thereof, the mesoporous metal organic framework is formed by connecting disulfide bond monomers and metal ions through non-covalent bonds, and the metal ions are Fe 2+ and Cu 2+. The mesoporous metal organic framework disclosed by the invention has the advantages of tumor microenvironment responsiveness, high drug loading capacity, low systemic side effect, good tumor local biodegradability, sufficient drug local release and low systemic side effect, and is expected to promote the further development of tumor ferroptosis and diagnosis and treatment integration.

Description

technical field [0001] The invention belongs to the technical field of drug research and development and preparation, and in particular relates to a mesoporous metal organic framework and its preparation method and application. Background technique [0002] Ferroptosis is an iron-dependent regulatory cell death that is different from the traditional form of apoptosis. It was proposed and named by Dixon et al. in 2012. In recent years, in order to deeply understand and reveal the pathogenesis of ferroptosis, scholars have conducted a lot of research on it, and initially discovered some regulatory mechanisms and signaling pathways of ferroptosis, such as the metabolism-related transport system of amino acids and glutathione: cysteine Amino acid / glutamate reverse transport system xc-, membrane phospholipids containing polyunsaturated fatty acids (PUFAs) in lipid metabolism are the main markers of lipid oxidation, the production of coenzyme Q10 (CoQ10), the accumulation of NAPDH...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00A61K41/00A61K47/32A61K47/10A61K31/704A61K31/337A61K31/519A61P35/00A61K49/00A61K49/12A61K49/22
CPCC08G83/008A61K41/0052A61K41/0057A61K47/32A61K47/10A61K31/704A61K31/337A61K31/519A61P35/00A61K49/0002A61K49/126A61K49/221A61K2300/00
Inventor 李颖嘉赵冰夏梁瑜彭超陈思雯钱昕张丽丹庆
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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