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Biwheel-shaped nanoparticles and preparation method thereof

A nanoparticle and double-wheel technology, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of complex preparation process, poor drug safety, and low drug loading. Achieve the effects of enhancing sensitivity, enhancing immunogenicity, and enhancing immune effect

Active Publication Date: 2022-06-03
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Based on this, it is necessary to provide a double-wheel-shaped nanoparticle and its preparation method for the problems of poor safety, low drug loading and complicated preparation process of traditional nanocarrier drugs.

Method used

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  • Biwheel-shaped nanoparticles and preparation method thereof
  • Biwheel-shaped nanoparticles and preparation method thereof
  • Biwheel-shaped nanoparticles and preparation method thereof

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preparation example Construction

[0058] c. reacting the second product with the hydrophobic adjuvant molecule.

[0062] The reaction time can be 20 hours, 22 hours, 24 hours, 26 hours, 28 hours. Preferably, the stirring temperature is 24

[0064] The reaction time can be 20 hours, 22 hours, 24 hours, 26 hours, 28 hours. Preferably, the stirring temperature is 24

[0067] In some embodiments, the hydrophobic adjuvant molecule undergoes an activation reaction prior to reacting with the second product. In a

Embodiment

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Abstract

The invention discloses a double-wheel-shaped nanoparticle, which is a spherical structure formed by the self-assembly of monomer molecules, and the monomer molecules include sequentially connected hydrophobic adjuvant molecules, antigens, environment-responsive linking molecules and hydrophilic Drug molecules, the hydrophobic adjuvant molecules are distributed on the inside of the spherical structure, and the hydrophilic drug molecules are distributed on the outside of the spherical structure. The invention discloses a preparation method of biwheel-shaped nanoparticles.

Description

Double wheel-shaped nanoparticles and preparation method thereof technical field [0001] The present invention relates to the technical field of medicine, in particular to double wheel-shaped nanoparticles and a preparation method thereof. Background technique Tumor is one of the important problems affecting human health and life at present, and a single treatment method often fails to achieve good results. In order to prolong the survival period of cancer patients and improve their quality of life, combination therapy has become the mainstay of cancer treatment. trend. However, the current tumor treatment mostly adopts the method of systemic administration, and the systemic toxicity and side effects are relatively large. nanocarriers, giving It has unique advantages in terms of drugs, which can not only increase the accumulation of drugs in the local tumor, enhance the therapeutic effect of drugs, but also Reduce systemic adverse reactions. In particular, in the a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/385A61K39/00A61K39/39A61K9/51A61K31/704A61K47/42A61K47/65A61P35/00A61P37/04
CPCA61K39/385A61K39/001195A61K39/39A61K47/65A61K31/704A61K9/5169A61P35/00A61P37/04A61K2039/575A61K2039/6031A61K2300/00
Inventor 刘兰霞冷希岗马兵邓博
Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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