A kind of mesoporous metal organic framework and its preparation method and application

A metal-organic framework and mesoporous technology, which is applied in the direction of organic active ingredients, medical preparations of non-active ingredients, medical preparations containing active ingredients, etc., to achieve high drug loading, low systemic side effects, and high purity.

Active Publication Date: 2022-03-25
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these studies all induced ferroptosis by the photosensitizer producing ROS and the GPX-4 inhibitor sorafenib

Method used

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  • A kind of mesoporous metal organic framework and its preparation method and application
  • A kind of mesoporous metal organic framework and its preparation method and application
  • A kind of mesoporous metal organic framework and its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1: A kind of preparation method of mesoporous metal organic framework:

[0054] (1) get N,N-dimethylformamide and dehydrated alcohol, be mixed into the composite solution that volume ratio is 5:3;

[0055] (2) Take the composite solution obtained in step (1) to prepare FeCl with a mass concentration of 100 mg / mL respectively 2 Solution, containing CuCl with a mass concentration of 100 mg / mL 2 The solution and the dithioglycolic acid solution with a mass concentration of 50 mg / mL were dissolved by ultrasonic respectively;

[0056] (3) FeCl prepared by step (2) 2 Solution and CuCl 2 solution according to Fe 2+ and Cu 2+ The molar ratio of 1:1 was added to a 15mL centrifuge tube, then 0.1mL of dithioglycolic acid solution, 250mg of PVP and 100μL of TEA were added, and the compound solution in step (1) was used to make up to 15mL, and ultrasonically dissolved. , placed in an autoclave, and reacted at 150°C for 24h;

[0057] (4) Step (3) The reactant was al...

Embodiment 2

[0058] Embodiment 2: A kind of preparation method of mesoporous metal organic framework:

[0059] (1) get N,N-dimethylformamide and dehydrated alcohol, be mixed with the composite solution that volume ratio is 3:2;

[0060] (2) Take the composite solution obtained in step (1) to prepare FeCl with a mass concentration of 200 mg / mL respectively 2 Solution, containing CuCl with a mass concentration of 100 mg / mL 2 The solution and the selenocysteine ​​solution with a mass concentration of 50 mg / mL were dissolved by ultrasonic respectively;

[0061] (3) FeCl prepared by step (2) 2 Solution and CuCl 2 solution according to Fe 2+ and Cu 2+ The molar ratio of 2:1 was added to a 15mL centrifuge tube, and then 0.1mL of selenocysteine ​​solution, 300mg of PVP and 200μL of TEA were added, and the compound solution in step (1) was used to make up to 15mL. Dissolve by ultrasonic , placed in an autoclave, and reacted at 135°C for 24h;

[0062] (4) Step (3) The reactant was allowed to ...

Embodiment 3

[0063] Embodiment 3: A kind of preparation method of mesoporous metal organic framework:

[0064] (1) get N,N-dimethylformamide and dehydrated alcohol, be mixed into the composite solution that volume ratio is 5:3;

[0065] (2) Take the composite solution obtained in step (1) to prepare FeCl with a mass concentration of 150 mg / mL respectively 2 Solution, containing CuCl with a mass concentration of 200 mg / mL 2 The solution and the dithioglycolic acid solution with a mass concentration of 50 mg / mL were dissolved by ultrasonic respectively;

[0066] (3) FeCl prepared by step (2) 2 Solution and CuCl 2 solution according to Fe 2+ and Cu 2+ The molar ratio of 11:4 was added to a 15mL centrifuge tube, and then 0.1mL of dithioglycolic acid solution, 200mg of PVP and 80μL of TEA were added, and the composite solution in step (1) was used. , placed in an autoclave, and reacted at 150°C for 24h;

[0067] (4) Step (3) The reactant was allowed to stand for cooling at room temperatu...

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Abstract

The invention provides a mesoporous metal organic framework and its preparation method and application. The mesoporous metal organic framework is formed by connecting a disulfide bond monomer and a metal ion through a non-covalent bond, and the metal ion is Fe 2+ and Cu 2+ . The mesoporous metal-organic framework of the present invention has tumor microenvironment responsiveness, high drug loading capacity, low systemic side effects, good local biodegradability of tumors, sufficient local release of drugs, and low systemic side effects. The mesoporous metal-organic framework is expected to promote Further development of tumor ferroptosis and integration of diagnosis and treatment.

Description

technical field [0001] The invention belongs to the technical field of drug research and development and preparation, and in particular relates to a mesoporous metal organic framework and a preparation method and application thereof. Background technique [0002] Ferroptosis, an iron-dependent regulated cell death that is different from traditional apoptosis, was proposed and named by Dixon et al. in 2012. In recent years, in order to deeply understand and reveal the pathogenesis of ferroptosis, scholars have conducted a lot of research on it, and initially discovered some regulatory mechanisms and signaling pathways of ferroptosis, such as the metabolism-related transport systems of amino acids and glutathione: Amino acid / glutamate reverse transport system xc-, membrane phospholipids containing polyunsaturated fatty acids (PUFAs) in lipid metabolism are major markers of lipid oxidation, production of coenzyme Q10 (CoQ10), NAPDH and selenium accumulation will Inhibition of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G83/00A61K41/00A61K47/32A61K47/10A61K31/704A61K31/337A61K31/519A61P35/00A61K49/00A61K49/12A61K49/22
CPCC08G83/008A61K41/0052A61K41/0057A61K47/32A61K47/10A61K31/704A61K31/337A61K31/519A61P35/00A61K49/0002A61K49/126A61K49/221A61K2300/00
Inventor 李颖嘉赵冰夏梁瑜彭超陈思雯钱昕张丽丹庆
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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