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Externally applied aceclofenac gel prepn and its prepn process

A technology of aceclofenac and gel, which is applied in anti-inflammatory agents, pharmaceutical formulas, non-central analgesics, etc., can solve research problems and achieve safe and convenient use, no toxic and side effects, and significant curative effect

Inactive Publication Date: 2007-08-22
夏泽宽 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this reason, this area hopes to develop the external use medicament of aceclofenac, to thoroughly eliminate the deficiency of its oral medicine, my country once had the research of the transdermal absorption of aceclofenac solution extracorporeal in 2004, but did not apply to applicable Do further research on transdermal dosage forms, especially for aceclofenac gel, which has never been reported on the applicable components and dosage range

Method used

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  • Externally applied aceclofenac gel prepn and its prepn process
  • Externally applied aceclofenac gel prepn and its prepn process

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Embodiment Construction

[0033] The present invention provides following embodiment, the present invention is described further:

[0034] Based on 100g of medicament, the weight ratio of the following components is:

[0035] 1. Aceclofenac 0.5g, propylene glycol 5g, ethylparaben 10g, sodium carbonate 0.01g, carbomer 940 0.5g and thioglycerol 5g, the balance is water.

[0036] 2. 7g of aceclofenac, 10g of propylene glycol, 0.001g of ethylparaben, 0.03g of sodium carbonate, 0.5g of carbomer 940 and 0.01g of thioglycerol, and the balance is water.

[0037] 3. Aceclofenac 8g propylene glycol 20g, ethylparaben 0.2g, sodium carbonate 1.5g, carbomer 940 2g and vitamin Clg, and the balance is water.

[0038] 4. Aceclofenac 3g, propylene glycol 25g, benzalkonium chloride 1.5g, sodium carbonate 0.2g, carbomer 940 1g, thioglycerol 3g, and the balance is water.

[0039] 5. Aceclofenac 4g, ethanol 30g, thimerosal 2g, sodium carbonate 2g, carbomer 9417g and thioacetic acid 2g, the balance is water.

[0040] 6. A...

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Abstract

The present invention discloses one kind of externally applied aceclofenac gel preparation and its preparation process. The externally applied aceclofenac gel preparation is compounded with aceclofenac 0.5-8 wt%, organic solvent 5-50 wt%, bacteriostat 0.001-10 wt%, pH regulator 0.01-2 wt%, carbomer 0.5-8 wt%, antioxidant 0.01-5 wt% and water for the rest. It is prepared through mixing the said ingredients. It is applied to the joint or other disease focus to result in obvious curative effect.

Description

technical field [0001] The invention relates to medicines, in particular to aceclofenac gel for external use and a preparation method thereof. Background technique [0002] Aceclofenac is a phenylacetic acid non-steroidal anti-inflammatory analgesic, the chemical name is: 2-[(2,6-dichlorophenyl) amino] phenylacetoxyacetic acid, listed in Spain in 1992, the dosage form is 100mg tablet, orally twice a day, 100mg each time, mainly treats the induced stage of degenerative joint disease, chronic arthritis, chronic migratory arthritis, chronic ankylosing back spondylitis and pain caused by various inflammations such as Low back pain, toothache and other diseases, although aceclofenac has the characteristics of safe medication and good curative effect, but it will cause some discomfort to the stomach after oral administration, and sometimes symptoms such as dizziness and elevated liver enzymes. Therefore, in recent years, Some scientific research institutions such as South Korea h...

Claims

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Application Information

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IPC IPC(8): A61K31/196A61K9/00A61K47/02A61K47/10A61K47/16A61K47/20A61K47/34A61P29/00
Inventor 夏泽宽孙秀芹
Owner 夏泽宽
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