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Platinum (ⅳ) and crgd-modified ga/fe nanoparticles loaded with doxorubicin and its method for targeted treatment of tumors

A nanoparticle and doxorubicin technology, which is applied in the field of biomedicine and tumor treatment, can solve the problems of poor curative effect, limited surgical resection range, and easy drug resistance, so as to achieve exact inhibitory effect, reduce drug resistance, Good targeted effect

Active Publication Date: 2022-03-18
SHANDONG UNIV QILU HOSPITAL
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Problems solved by technology

Since the GBM growth site is intracranial, this severely limits the extent of surgical resection, resulting in a recurrence rate of approximately 90% after surgery
The mechanism of action of traditional chemical drugs and targeted drugs is mainly to induce tumor cell apoptosis, but due to the existence of GBM heterogeneity, a single chemotherapy drug or molecular targeted drug has poor efficacy and is prone to drug resistance

Method used

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  • Platinum (ⅳ) and crgd-modified ga/fe nanoparticles loaded with doxorubicin and its method for targeted treatment of tumors
  • Platinum (ⅳ) and crgd-modified ga/fe nanoparticles loaded with doxorubicin and its method for targeted treatment of tumors
  • Platinum (ⅳ) and crgd-modified ga/fe nanoparticles loaded with doxorubicin and its method for targeted treatment of tumors

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Embodiment Construction

[0081] Materials and Methods

[0082] 1. Preparation of DSPE-PEG(2000)Pt(IV) and DSPE-PEG(2000)-cRGD: the cis, cis and trans [PtIV(NH 3 ) 2 Cl 2 (O 2 CCH 2 CH 2 CO 2 h) 2 ] (9.6mg, 18.0μmol), dicyclohexylcarbodiimide (3.7mg, 18.0μmol) and 4-(dimethylamino)pyridine (1.0mg, 7.2μmol) were dissolved in DMSO (130μL), after 10min the The solution containing the active Pt(IV) complex was added to the prepared DSPE-PEG(2000)-NH 2 (10mg, 3.6μmol, 170μL) DMSO solution, the resulting mixture was continuously stirred and reacted at room temperature for 72 hours, and the reaction product was centrifuged with water, and the supernatant was dialyzed and purified on an ultrafiltration filter with a molecular weight of 2000 to obtain DSPE- PEG(2000)Pt(IV). In the same way, cRGD was coupled with PEGylated phospholipids, and DSPE-PEG(2000)-cRGD was obtained by dialysis and purification.

[0083] 2. Preparation of GA / Fe nanoparticles: 23mg FeCl 2 -4H 2 O and 80mg PVP were added to 4m...

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Abstract

The invention provides platinum (IV) and cRGD modified GA / Fe nanoparticles carrying doxorubicin and a method for targeted treatment of tumors, belonging to the technical field of biomedicine and tumor treatment. The present invention creatively constructs GA / Fe nanoparticles loaded with doxorubicin modified by cisplatin Pt(IV) prodrug and cRGD. By combining DOX, it can synergistically induce apoptosis of tumor cells with Pt(II), while GA / Fe Fe nanoparticles release a large amount of Fe under the stimulation of near-infrared light 2+ , to induce the Fenton reaction in the cells, and further promote the ferroptosis of the cells. Maximizing the anti-tumor effect of nano-drugs is a new method for targeted nano-drugs to treat glioma, so it has good practical application value.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and tumor treatment, and in particular relates to platinum (IV) and cRGD modified GA / Fe nanoparticles loaded with doxorubicin and a method for targeted treatment of tumors. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Glioma is considered one of the deadliest and most difficult to treat cancers. Glioma can be divided into 4 grades according to the degree of malignancy (WHO I, II, III and VI), and the most common glioma is type IV glioma, also known as glioblastoma (GBM). Currently, the preferred treatment for newly diagnosed glioma patients under the age of 70 is surgical resection, fol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/26A61K9/127A61K47/69A61K47/60A61K47/64A61K47/12A61P35/00B82Y5/00B82Y30/00B82Y40/00A61K41/00A61K31/704A61K33/243
CPCA61K33/243A61K31/704A61K33/26A61K47/6911A61K9/127A61K47/12A61K47/60A61K47/6929A61K47/64A61P35/00B82Y5/00B82Y30/00B82Y40/00A61K41/0042A61K2300/00
Inventor 倪石磊张玉霖封帆
Owner SHANDONG UNIV QILU HOSPITAL
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