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Chitosan oligosaccharide composition and preparation method and application thereof

A technology of chitosan oligosaccharide and composition is applied in the field of chitosan oligosaccharide composition and preparation thereof, which can solve the problems of low bioavailability, slow dissolution of chitosan tablets or capsules, etc., and achieves simple preparation method and liver protection. The mechanism of action is novel, and it is convenient for industrialized large-scale production.

Inactive Publication Date: 2020-09-18
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN105496981A discloses a kind of chitosan oligosaccharide tablet, and Chinese patent CN105380924A discloses a kind of chitosan oligosaccharide capsule, but the dissolution of chitosan tablet or capsule is slow, and bioavailability is low

Method used

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  • Chitosan oligosaccharide composition and preparation method and application thereof
  • Chitosan oligosaccharide composition and preparation method and application thereof
  • Chitosan oligosaccharide composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] COST 10g, COSM 20g, sodium bisulfite 1g, sodium chloride 8.40g

[0055] Preparation method: Add sodium chloride to 800ml water for injection, add sodium bisulfite, stir until completely dissolved, then add COST and COSM, stir until completely dissolved, add dropwise a small amount of sodium hydroxide solution and dilute hydrochloric acid solution to adjust the pH to 6.0~7.0, add 0.6g activated carbon for needles, coarsely filter, add water for injection to make the solution volume 1000ml, put it into an ampoule after fine filtration, seal and sterilize to obtain the chitosan oligosaccharide composition.

Embodiment 2

[0057] COST 10g, COSM 15g, sodium bisulfite 1g, sodium chloride 8.45g

[0058] Preparation method: Add sodium chloride to 800ml water for injection, add sodium bisulfite, stir until completely dissolved, then add COST and COSM, stir until completely dissolved, add dropwise a small amount of sodium hydroxide solution and dilute hydrochloric acid solution to adjust the pH to 6.0 to 7.0, add 0.2 g of activated carbon for needles, coarse filter, add water for injection to make the solution volume 1000 ml, put it into an ampoule after fine filtration, seal and sterilize to obtain the chitosan oligosaccharide composition.

Embodiment 3

[0060] COST 10g, COSM 10g, sodium bisulfite 1g, sodium chloride 8.5g

[0061] Preparation method: Add sodium chloride to 800ml water for injection, add sodium bisulfite, stir until completely dissolved, then add COST and COSM, stir until completely dissolved, add dropwise a small amount of sodium hydroxide solution and dilute hydrochloric acid solution to adjust the pH to 6.0~7.0, add 0.8g activated carbon for needles, coarse filter, add water for injection to make the solution volume 1000ml, put it into an ampoule bottle after fine filtration, seal and sterilize to obtain the chitosan oligosaccharide composition.

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Abstract

The invention provides a chitosan oligosaccharide composition. The chitosan oligosaccharide composition mainly comprises chitosan oligosaccharide, an antioxidant, an osmotic pressure regulator, a pH regulator and the like, wherein the chitosan oligosaccharide is composed of chitosan oligosaccharide 1000 (COST) and chitosan oligosaccharide 3000 (COSM). The composition is in the form of an injection, the preparation process is simple and convenient, and industrial production is facilitated. The chitosan oligosaccharide composition provided by the invention can significantly reduce the increase of ALT and AST when acetaminophen induces liver injury, and can reduce MDA and increase GSH content, indicating that COST and COSM can reduce oxidative injury; in addition, the content of liver antioxidant enzyme, including SOD, GSH-Px and CAT, can be significantly increased, indicating that the oxidation resistance of the liver can be improved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a chitosan oligosaccharide composition and a preparation method and application thereof. Background technique [0002] Chitin (chitin), a water-insoluble cationic aminopolysaccharide with β-1,4-linked N-acetylglucosamine (GlcNAc) monomers, is the most abundant biomass after cellulose and is commonly found in the shells of crustaceans , insect cuticles, and fungal cell walls. Treatment of chitin with an alkaline solution converts it to chitosan: a fully or partially deacetylated form of chitin. Chitosan can be defined as a natural non-toxic biopolymer, a linear polysaccharide composed of β-1,4-GlcNAc and β-1,4-GlcN. Chitosan is water insoluble but soluble in aqueous organic acid solutions. The acetylation unit content of chitin exceeds 70%, while the acetylation rate of chitosan is less than 30%. In organic acids, such as formic acid, acetic acid and ascorbic a...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/722A61K47/02A61K47/22A61P1/16
CPCA61K31/722A61K47/02A61K47/22A61K9/08A61P1/16
Inventor 苏政权曹华白研
Owner GUANGDONG PHARMA UNIV
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