401results about How to "Easy to industrialize mass production" patented technology

The invention relates to a gemcitabine hydrochloride lyophilized powder injection and a preparation method thereof. The gemcitabine hydrochloride lyophilized powder injection prepared by the method can be used as a therapeutic medicament for treating middle and late non-small cell lung cancer, pancreatic cancer and the like. The gemcitabine hydrochloride lyophilized powder injection is characterized by consisting of gemcitabine hydrochloride, mannitol and sodium acetate, wherein the weight ratio of the gemcitabine hydrochloride to the mannitol is 1:0.5-5, and the weight ratio of the gemcitabine hydrochloride to the sodium acetate is 1:0.01-0.1. The preparation method comprises the following steps: taking the mannitol and the sodium acetate; dissolving the mannitol and the sodium acetate by adding injection water; adding the gemcitabine hydrochloride to the mixture, stirring and dissolving the mixture, and adjusting the pH to between 2.7 and 3.3; fixing the volume; filtering the product by a 0.22 mu m microporous membrane; filling, dishing up, lyophilizing, and compressing; taking the product out of a box, and tying the product with an aluminum-plastic composite cover; and inspecting the quality, and packaging the product after passing the quality inspection to obtain the gemcitabine hydrochloride lyophilized powder injection.

The invention relates to the field of medicine preparation, in particular to a melittin lipidosome preparation. The lipidosome preparation is composed of one part of melittin, 5-40 parts of phospholipid, 1.3-10 parts of cholesterin and 10-140 parts of poloxamer. The invention also discloses the preparing method of the melittin lipidosome preparation. The melittin lipidosome preparation not only can delay the medicine release in the lipidosome, prong the circulating time in the blood and improve the bioavailability of the medicine, but also can obviously reduce the side effect of the medicine and improve the adaptability of a patient.

A high-effective catalyst used for removing indoor formaldehyde at normal temperature includes a carrier, a noble active component, and an additive. The carrier is a mesoporous oxide including at least one of Al2O3, TiO2, SiO2, cerium oxide, cobalt oxide and manganese oxide; the active component includes a less amount of at least one of noble metals Pd, Pt, Au and Ag; the additive is at least one of Na, K, Fe, Co, Ce and Ni. The catalyst can completely convert the formaldehyde into CO2 and H2O at normal temperature under relative humidity of 50-90%. The catalyst has high catalytic-oxidizing activity and strong anti-moisture capability and is suitable for removal of the formaldehyde in a sealed or a semi-sealed space.

The invention relates to a pantoprazole sodium freeze-dried powder injection and a preparation method thereof. The powder injection is prepared from pantoprazole sodium and mannitol, wherein the consumption ratio of the pantoprazole sodium to the mannitol is (1:0.8)-(1:1.6), and the PH value is 10.5-11.0. In the invention, by lowering the pre-freezing temperature, properly lowering the freezing temperature, maintaining the lowered freezing temperature for a proper time, properly shortening two-stage drying time and carrying out other adjustment processes, good appearance and quality of the product can be kept under the condition that the content of the mannitol is low, the processes are reliable and feasible, and the effect is obvious. The prepared product has low content of related substances and has controllable quality, and the freeze-dried product has good clarity and formability after being redissolved.

The invention relates to antibacterial functional fibers and belongs to the field of polymer material. In the invention, carrier fibers and aqueous solution of an inorganic metal antibacterial agent are mixed and stirred at a constant temperature of 0 to 100 DEG C for 10 minutes to 24 hours first, then the fibers are taken out and washed by deionized water till the pH value of the fibers is 6.5 to 7.5, and finally the fibers are dried at 40 to 60 DEG C to give the target product. In the invention, the raw materials are widely available, the synthesis process is simple, the synthesis process is easy to control, and industrial production is easy to realize. The fibers have a broad antibacterial spectrum and long-lasting antibacterial performance, is safe and reliable, and can be made into health-care underwear, insoles, operation clothes, nurse clothes, medical gauzes and the like. The fibers can also be made into nonwoven fabrics used for making filter elements of air purifiers for killing bacteria and germs in the air, and therefore have a promising application prospect.

The invention belongs to the technical field of medicines and relates to a puerarin nanocrystalline medical composition and a preparation method and application thereof. Specifically, the puerarin composition is a puerarin nanocrystalline composition. The puerarin composition provided by the invention remarkably improves the solubility and bioavailabilityof puerarin and reduces or eliminates the food effect of the medicine, and is good in stability and can be prepared into various common preparation forms easily, the stability and effect of the medicine are improved, so that the composition has good prospect.

The invention discloses a nutritional whole-grain cereal meal and a preparation method thereof, and belongs to the field of food processing. The nutritional whole-grain cereal meal is prepared from the following raw materials in parts by weight: 15-25 parts of black rice, 5-10 parts of semen sesami nigrum, 5-10 parts of oat, 1-5 parts of black glutinous rice, 1-5 parts of black bean flour, 1-5 parts of oatmeal, 1-2 parts of purple sweet potatoes and purple Chinese yam or 1-2 parts of freeze-drying raw materials. The preparation method comprises the following working procedures of frying the semen sesami nigrum, puffing the black rice and the black glutinous rice, crushing raw materials, mixing and the like. The nutritional whole-grain cereal meal has the characteristics of low content of fat, high content of proteins, dietary fibers and vitamins, relatively reasonable nutrition match, relatively convenience in preparation, and rich mouthfeel, can effectively remedy the problems of poor nutrition replenishment, low proteins, inconvenience in eating, poor mouthfeel and the like in existing foods (especially the food for breakfast), so that the dietary structure for the breakfast becomes reasonable.

The invention provides a ternary positive electrode material, a preparation method thereof and a lithium ion battery. The ternary positive electrode material is mainly composed of a high-nickel ternary material core and a cobalt borate coating layer. The preparation method comprises the steps of 1) mixing a boron source and a cobalt source, and sintering in a protective atmosphere to obtain cobaltborate; and 2) mixing cobalt borate with the high-nickel ternary material, and heating in an oxidizing atmosphere to obtain the ternary positive electrode material. According to the ternary positiveelectrode material provided by the invention, the high-nickel ternary material core, the cobalt borate coating layer and the lithium cobalt borate positioned between the high-nickel ternary material core and the cobalt borate coating layer are matched with one another, so that the ternary positive electrode material is low in residual alkali content and good in rate discharge capacity and cycle performance. The preparation method provided by the invention is short in process, simple to operate and easy for industrial large-scale production.

The invention discloses a novel synthesis method of palonosetron hydrochloride, which comprises that (1) (S)-tetralin formic acid is reacted with thionyl chloride and (S)-3-amido-quinine cyclic amine, to obtain (S, S)-quinuclidine tetralin formamide, (2), (S, S)-quinuclidine tetralin formamide is reacted with reductant and boron trifluoride diethyl etherate, to obtain (S, S)-tetralin methyl quinine cyclic amine, (3), (S, S)-tetralin methyl quinine cyclic amine is reacted with diphosgene to be added and reacted in boron trifluoride diethyl etherate solution, while the product is added and reacted with alcaine and water, to obtain palonosetron hydrochloride. And the synthesis route is represented as above: a: SOCI2, (S)-3-aminoquinuclidine, b: NaBH4, BF3OEt2, c: BF3OEt2, CICO2CCI3.

The invention provides a dry garment leather base and a preparation process thereof. The preparation process includes the steps: 1) base cloth treatment: completely soaking base cloth in mixed solution of soluble calcium salt and leather softeners, mangling the base cloth and then ironing and drying the base cloth by an ironing roller; 2) coating the base cloth with 200-500g/m<2> of garment leather base foaming slurry by a scraping method; 3) drying the base cloth in a drying oven; 4) base rolling: cooling and rolling the base cloth by a cooling roller to prepare the dry garment leather base. The prepared dry garment leather base has good moisture and air permeability, is quite soft in hand feeling and good in rebound resilience and wear resistance, and can meet higher performance requirements and environmental protection standards.

The invention discloses a roxburgh rose vinegar beverage and a preparation method thereof. The roxburgh rose vinegar beverage is a liquid beverage which is prepared by fermenting the following components in parts by weight: 10 to 50 parts of roxburgh rose dregs, 1 to 5 parts of roxburgh rose fruits and/or 4 to 8 parts of roxburgh rose juice. According to the preparation method, the roxburgh rose dregs are used as the main raw material, and a small amount of roxburgh rose fruits and/or roxburgh rose juice is used to prepare the roxburgh rose vinegar beverage; the preparation process mainly comprises the steps of alcohol fermentation, acetic fermentation, filtration, dilution and seasoning; and compared with a product of the prior art, the prepared roxburgh rose vinegar beverage is rich in nutrient components and genuine in flavor, keeps the unique flavor of roxburgh roses, is convenient and easy to produce, and is lower in cost and easier for industrial mass production. Moreover, the roxburgh rose vinegar beverage is prepared from the commonly discarded roxburgh rose dregs as the main raw material, thus having great significance for comprehensive development and full utilization of the roxburgh roses; and the utilization ratio of the roxburgh roses and the generated economic benefit are far higher than those of the prior art.

The invention relates to rabeprazole sodium lyophilized powder for injection, which is used to treat gastric ulcer, duodenal ulcer, stomal ulcer, reflux esophagitis and Zollinger-Ellison syndrome. The freeze-dried powder for injection contains rabeprazole sodium and meglumine in the mass ratio of 1:0.1-1. The preparation method of the freeze-dried powder for injection comprises the following steps of putting the meglumine in an aseptic container, adding water for injection for dissolution and homogenization, adding the rabeprazole sodium and other adjuvant materials, stirring for dissolution and homogenization, measuring intermediate content, filtering with a microporous membrane with a particle size of 0.22 mum under aseptic conditions if the intermediate content is qualified until filtrate is clarified, filling the filtrate in aseptic vials, sealing the vials partially with butyl rubber stoppers, loading on a disk, freeze-drying, boxing, sealing, testing quality and packaging.

The invention relates to a preparation method of a self-microemulsion nanometer composition of ganodenic acid extract; the self-microemulsion nanometer composition takes ganodenic acid extract as crude drug, and the mixture of surface active agent, cosurfactant, and oil phase is adopted as drug carrier; the preparation method is characterized in that: the components are as follows by weight part: 10 parts of ganodenic acid extracts, 50-400 parts of surface active agents, 100-800 parts of cosurfactants, and 15 to 600 parts of oil phase; the ganodenic acid extract is total triterpenoids in ganoderma lucidum which is obtained by extracting lucid ganoderma fruiting body with a supercritical CO2 extracting method. In the method, the total triterpenoids in ganoderma lucidum, which is an insolubility drug, is prepared into self-microemulsion formulation, so as to improve the dissolution rate of the drug, promote the drug adsorption and be beneficial to improving the bio-availability; in addition, the drug can keep a dissolution state in intestine so as to better to permeate through cell membranes dispersedly, thereby improving the drug effect of the drug and enhancing the in-vivo anti-tumor effect.

The invention relates to a preparation method of a load-typed nanometer Pt (Pt-M)/ carrier catalyst, which comprises that a carrier is uniformly dispersed in a chloroplatinic acid solution to obtain an electrolyte which is then infused to a ultrasound-imposed double-platinum-electrode electrolysis bath for electrodeposition, so as to obtain a catalyst suspension of a nanometer Pt (Pt-M) catalyst which is uniformly loaded on the carrier and then separated to obtain the load-typed nanometer Pt (Pt-M)/ carrier catalyst. The preparation method loads the nanometer Pt (Pt-M) on the carrier directly, thus avoiding the defects of high-temperature reduction or use of reducers for preparation of other methods; the preparation method does not require to conduct separate activation or modification treatment to the carrier and has the advantages of simple process and catalyst with adjustable size, low cost and no environmental pollution, thus being a universal method easy for industrialized massive production. By determining with cyclic volt-ampere curves, in terms of performance, 40 percent load-typed nanometer Pt/C catalyst prepared by the invention is superior to similar products produced by the worldwide advanced Johnson Matthey Company.

The invention discloses a preparation method of high-purity hyodeoxycholic acid. The preparation method comprises the steps: weighing raw materials, adding strong alkaline and water, saponifying at the temperature of 95-100 DEG C for 16-24h, cooling to room temperature, standing, siphoning to remove a supernatant liquid, adding water into paste in the lower layer, stirring for dissolving the paste, adding strong acid to acidize until a congo red test paper turns to be blue, adding ethyl acetate, stirring for extracting for 20-50min, standing for layering, removing a water phase, adding water into the ethyl acetate to wash until the pH value of the water phase is equal to 6-7, adding the ethyl acetate into anhydrous sodium sulfate to dehydrate, carrying out activated carbon decoloration, filtering, concentrating until precipitates are separated out, cooling, filtering or squeezing and drying in vacuum; adding an alcohol solvent, stirring for dissolving the above product, slowly adding an alkaline organic solvent, stirring, cooling, separating out a great number of precipitates, filtering and drying; and adding water and sodium hydroxide, stirring for dissolving, dropwise adding hydrochloric acid with a volume concentration of 1:1, stirring, filtering and drying to obtain the hyodeoxycholic acid. The invention aims to provide the preparation method of the hyodeoxycholic acid with simple process, high yield and high purity.

The invention discloses a novel inflatable fire-retardant of general formula (I). In terms of preparation method, a reaction of polyhydroxy compound and phosphoric acid or ammonium phosphate salt is conducted to achieve phosphate ester; a reaction of urea and formaldehyde is conducted to achieve urea-formaldehyde resin; and then the achieved phosphate ester and urea-formaldehyde resin are solidified by crosslinking to achieve the final product. The fire-retardant is applied to various polymers for fire-retarding, particularly applicable to fire-refractory coatings for inflatable fire-retarding.

The invention discloses a preparing method of pnenolic aldehyde type adsorbing resin and preparing, which comprises the following steps: comprising large hole spherical (or granular) with fenol unit pnenolic aldehyde type absorbing resin, large hole spherical (or granular) with catechol unit pnenolic aldehyde type absorbing resin and large hole granular pnenolic aldehyde type absorbing resin with phloroglucine unit; choosing cavaform (or formaldehyde water solution), fenol or catechol or phloroglucine raw material to prepare large hole spherical (or granular) pnenolic aldehyde type adsorbing resin; adopting anti-phase floating polycondensation method or solution polycondensation method to synthesize under existence of special hole agent ethandiol (or glycerin); finishing synthesized reaction under existence of acid catalyst. This preparing method is simple and can finish with one step, which can simplify process and decrease cost.

The invention relates to a levocarnitine composition for injection and a preparation method of the levocarnitine composition; the levocarnitine composition is lyophilized powder containing levocarnitine and mannitol, wherein the weight ratio of the levocarnitine to the mannitol is 1:(0.75-1.25); the average particle diameter of the lyophilized powder is 90-130 nm, and the porosity is 94-98%. The preparation method comprises the steps of: 1) preparing: weighing levocarnitine and mannitol, putting the levocarnitine and the mannitol in a preparing tank, adding injection water, agitating to enable the levocarnitine and the mannitol to be completely dissolved and uniformly mixing, regulating the pH to 5.7-6.3 through a 0.1mol/L hydrochloric acid solution; 2) decarburizing and sterile filtering; 3) sterile packaging; 4) vacuum freeze drying to obtain the levocarnitine composition . The levocarnitine composition has the advantages of simple preparation, advanced technique, uniform quality, excellent stability, better redissolution capability and clinic medicine application safety.

The invention relates to a tigecycline freeze-dried powder injection, which consists of tigecycline, dextran, sodium sulfite and sodium citrate according to the following weight proportion: 10 portions of the tigecycline, 10 to 90 portions of the dextran, 0.1 to 3 portions of anhydrous sodium sulfite, and 0.1 to 3 portions of the sodium citrate. The pH value of the tigecycline freeze-dried powder injection is between 7.0 and 9.0. The preparing process comprises the following steps: firstly, dissolving the dextran by 80 percent of water for injection; secondly, adding the sodium citrate and the anhydrous sodium sulfate into the mixture after cooling; thirdly, adding the tigecycline into the mixture after dissolving and evenly stirring the sodium citrate and the anhydrous sodium sulfate, and mixing the mixture evenly; and fourthly, regulating the pH to between 7.0 and 9.0, adding a needle activated carbon into the mixture, stirring and adsorbing the mixture, removing the activated carbon from the mixture, and fixing the capacity. The solution is filtered through two microporous membranes and then are filled in a cillin bottle, and the tigecycline freeze-dried powder injection is obtained through semi-stoppering, spanning, freeze-drying, introducing nitrogen, performing tamponade, taking out the injection from a box, rolling a mouth, passing the quality inspection, and packaging.

The polygelatin peptide injection is prepared with gelatin of ox bone, pig bone, etc. and through dissolving, hot degradation in controlled condition, cross-linking with non-toxic cross-linking agent, mixing with electrolyte, adsorption, clarification and stepped filtering to separate cross-linked spherical molecule. During the preparation, the molecular weight of the cross-linked matter is well controlled.