Self-microemulsion nanometer composition of ganodenic acid extract and preparation method thereof
A nano-composition, Ganoderma lucidum triterpenes technology, applied in the field of self-microemulsification nano-composition preparation, can solve the complex composition of traditional Chinese medicine components, no research reports on self-microemulsion preparations of Ganoderma triterpenes, research difficulties, etc. problem, to achieve the effect of good absorption, good emulsification performance and simple preparation method
Active Publication Date: 2009-12-16
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology
Due to the complex composition of traditional Chinese medicine components, even the same type of components contain multiple chemical components, so it is difficult to study the effective components of traditional Chinese medicine from microemulsion
Therefore, there is no research report on the self-microemulsion preparation of triterpenoid components of Ganoderma lucidum
Method used
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Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0041] Prescription: Ganoderma lucidum total triterpene extract 30mg, Tween-20 1200mg, isopropanol 2400mg, oleic acid 1800mg.
[0042] Put the total triterpene extract of Ganoderma lucidum, Tween-20, and isopropanol into a vial, and mix them well by magnetic stirring. Terpene extract self-microemulsifying composition.
Embodiment 2
[0044] Prescription: Ganoderma lucidum total triterpene extract 100mg, Span-20 1000mg, ethanol 6000mg, ethyl oleate 500mg.
[0045] The preparation method is the same as in Example 1.
Embodiment 3
[0047] Prescription: Ganoderma lucidum total triterpene extract 50mg, phospholipid-20 250mg, ethanol 500mg, isopropyl myristate 75mg.
[0048] The preparation method is the same as in Example 1.
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The invention relates to a preparation method of a self-microemulsion nanometer composition of ganodenic acid extract; the self-microemulsion nanometer composition takes ganodenic acid extract as crude drug, and the mixture of surface active agent, cosurfactant, and oil phase is adopted as drug carrier; the preparation method is characterized in that: the components are as follows by weight part: 10 parts of ganodenic acid extracts, 50-400 parts of surface active agents, 100-800 parts of cosurfactants, and 15 to 600 parts of oil phase; the ganodenic acid extract is total triterpenoids in ganoderma lucidum which is obtained by extracting lucid ganoderma fruiting body with a supercritical CO2 extracting method. In the method, the total triterpenoids in ganoderma lucidum, which is an insolubility drug, is prepared into self-microemulsion formulation, so as to improve the dissolution rate of the drug, promote the drug adsorption and be beneficial to improving the bio-availability; in addition, the drug can keep a dissolution state in intestine so as to better to permeate through cell membranes dispersedly, thereby improving the drug effect of the drug and enhancing the in-vivo anti-tumor effect.
Description
technical field [0001] The present invention relates to a self-microemulsifying nano-composition of ganoderma lucidum triterpene extract, the nano-composition prepares the water-insoluble drug ganoderma total triterpene extract into a self-micro-emulsifying preparation, and the present invention also relates to this self-micro-emulsifying nano-composition method of preparation. Background technique [0002] Ganoderma lucidum is a polyporaceae fungus with a medicinal history of thousands of years, which was recorded in the earliest Chinese herbal monograph "Shen Nong Ben Cao Jing". For more than two thousand years, people have been using Ganoderma lucidum to prevent and treat tumors; modern scientific research also shows that Ganoderma lucidum has a strong anti-tumor effect. [0003] Ganoderma lucidum triterpenoids are recognized as one of the anti-tumor active ingredients of Ganoderma lucidum. However, its water solubility is very poor, which affects its oral absorption an...
Claims
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Patent Timeline
Login to View More IPC IPC(8): A61K36/074A61K9/107A61K47/44A61K47/34A61K47/32A61P35/00A61K47/10A61K47/26
Inventor 陈彦贾晓斌宋师花
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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