22 results about "Drug adsorption" patented technology

The invention provides a therapeutic drug monitoring kit and method and system, a magnetic bead extraction method is combined with LC-MS / MS detection to be applied to human blood drug concentration monitoring, a mixed magnetic bead solution containing phospholipid removal magnetic beads and to-be-detected drug adsorption magnetic beads is utilized to perform adsorption and extraction pretreatment on a to-be-detected drug in a sample, automatic treatment equipment is matched, and the concentration of the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug is detected. The pretreatment efficiency is high, the phospholipid content in the supernate is low, and the matrix effect and the chromatographic column washing pressure are greatly reduced. According to the therapeutic drug monitoring method provided by the invention, a unified pretreatment process is used, simultaneous extraction of multiple drugs is realized, and through a magnetic bead automatic extraction method, the pretreatment step of a sample can be rapidly completed, a therapeutic drug monitoring result can be rapidly obtained, the overall detection time is shortened, and the detection efficiency is improved. Therefore, a reliable laboratory examination basis is provided for individualized treatment.

The invention relates to the technical field of medicinal packaging container manufacturing, and discloses a processing technology of a double-cavity cartridge bottle, which comprises the following steps: glass tube loading: selecting a glass tube as a raw material, loading the glass tube into a clamping mechanism of forming equipment, fixing the glass tube through a positioning assembly, enabling the axis of the glass tube to coincide with a processing datum line of the equipment, and forming the glass tube; according to the processing technology of the double-cavity cartridge bottle, double-cavity integrated forming is adopted, the strength and the sealing performance of a separation structure of the main body cavity and the bypass cavity are effectively improved, the sealing hidden danger of split splicing is avoided, the leakage and fracture risks are greatly reduced, the technology is matched with the two forming means that a guide pipe is inserted into blow molding and matched with a mold, and medicinal glass raw materials are compatible; the double-cavity cartridge bottle meets the requirements of medical storage for stability and adaptability, meets the storage requirements of various drugs, reduces drug adsorption and chemical reactions, broadens clinical application scenes, and remarkably improves the practical value of the double-cavity cartridge bottle.

The invention relates to the field of biomedical materials, in particular to a composite carrier for targeted drug delivery based on a diatom shell, and the carrier utilizes a natural diatom shell porous structure to anchor FeOmagnetic nanoparticles and graft a PNIPAM-co-AAc temperature-sensitive polymer film on the shell surface through oxygen plasma pretreatment and Schiff base reaction. The carrier realizes double-drug loading: a hydrophobic drug is loaded in a shell pore channel, and a hydrophilic drug is adsorbed on the surface of the membrane. And the anti-immune layer is grafted through a PEG silane coupling agent, so that the in-vivo circulation is prolonged to 45 hours. Heat is generated to 42-45 DEG C in an alternating magnetic field to trigger the temperature-sensitive film to shrink and release drugs, meanwhile, cancer cells are directly killed through thermal therapy, and the tumor inhibition rate reaches 78% and is remarkably improved compared with a traditional magnetic targeting carrier. Precise synergy of magnetic hyperthermia and drug release is achieved through structural innovation, and an efficient and low-toxicity solution is provided for cancer treatment.

The invention discloses a medicinal glass bottle and a forming process thereof, and belongs to the technical field of medical materials, the medicinal glass bottle comprises a glass bottle body and a composite coating on the inner wall of the glass bottle; the forming process comprises the following steps: 1) pretreating the glass substrate; 2) constructing a composite layer; 3) constructing a barrier layer; and 4) cross-linking inerting and post-processing. According to the inner wall coating designed by the invention, a sandwich structure is adopted, and strong adhesive force of a bottom layer is realized through amino silane; the silver nanoparticles are anchored in situ by using a branched polyethyleneimine network, so that stable antibiosis is realized; a compact zwitterionic polymer brush is constructed on the outermost layer through surface-initiated polymerization, and a super-hydrophilic and biologically inert surface is provided; and finally, through cross-linking inerting treatment, the stability and safety of the coating are greatly improved. The problems of medicine adsorption, microorganism breeding, coating instability and the like of a traditional packaging material are solved, and a safe and reliable novel solution is provided for medicine packaging.

The invention discloses a titanium-based orthopaedic implant capable of rapidly adsorbing drugs and a construction method and application thereof. According to the construction method, the optimal parameters for constructing surface anodic oxidation and drug adsorption of the orthopedic implant can be determined, the parameters comprise an implant pretreatment process, anodic oxidation time and voltage, and thus modification of the surface of the orthopedic implant can be guided. The construction method is simple and efficient, the orthopedic implant can achieve rapid and efficient adsorption and release of drugs after surface modification, the problems that a traditional adsorption method is tedious in process and time-consuming are solved, and the drug loading rate of the orthopedic implant is increased.

The present invention relates to the field of compound detection technology, and discloses a preparation method of a magnetic MOF composite material and a detection method for chemicals. The magnetic MOF composite material is a core-shell structure, including a magnetic core, an outer metal organic framework structure, and the metal organic framework structure has 2 to 5 nm pores on the surface. The pores contain one or more of carboxyl groups, aromatic groups, hydrophobic bonds, π-π bonds, salt bonds, and hydrogen bond binding sites, and are used to adsorb psychiatric drugs in serum. The adsorption recovery rate is 94% to 113%, and the protein exclusion rate exceeds 95%. The present invention has the advantages of rapid magnetic separation, efficient adsorption of psychiatric drugs in serum, and a high protein exclusion rate, which can simplify the detection process and reduce the detection error caused by protein interference.

This invention provides a drug delivery device pad. The pad comprises an elastic outer layer, a sealing middle layer, and a leak-proof inner layer stacked sequentially, with the three layers integrally connected by heat fusion, adhesive bonding, or welding. The elastic outer layer is made of silicone or polyurethane, providing flexible cushioning to prevent relative sliding with the drug delivery device; the sealing middle layer is made of EPDM rubber or hydrogenated nitrile rubber, enhancing pressure resistance and long-term sealing performance; the leak-proof inner layer is made of fluororubber or polytetrafluoroethylene, forming an inert protective layer to block the risk of drug adsorption or oxidation. The layers are connected by an interlocking structure and a locking block-slot physical locking method, achieving double fixation and preventing peeling. This invention balances elastic deformation and structural stability, effectively solving the problems of easy deformation and damage, poor sealing performance, and drug adsorption in traditional pads, significantly improving the sealing reliability and drug protection performance of the drug delivery device.

A fluid dynamic valve passively allows fluid flow out of a moving stream in one flow direction and not in the reverse. This allows the collection of fluid from a single direction of an AC fluid flow. The siphoned portion of the flow has a flow rate proportional to the mainstream flow. This device can collect exhaled breath or selective entrenchment during inhale. In one orientation, it can meter aerosolized particles into an inhale breath stream for pulmonary delivery, without complicated breath timing or drug loss due to drug adsorption to the back of the throat. Alternatively, a user can breathe through the device and a proportional amount, relative to the volumetric flow rate, of each exhale can flow into an auxiliary chamber for analysis. In addition, the device has a low respiratory burden and is comfortable to use.

The invention relates to an iron-nitrogen-carbon-based magnetic material for synchronously removing combined pollution of iron and ibuprofen drugs in underground water and an application of the iron-nitrogen-carbon-based magnetic material. The material can stably adsorb iron ions in water through a surface carboxyl complexing way, and the adsorbed iron ions are used as a medium to fix carboxyl groups of ibuprofen drugs on the surface of the material, so that the effect of synchronously adsorbing and removing iron and ibuprofen drugs in water is realized. The method is suitable for synchronous adsorption removal of polymorphic iron and various ibuprofen drugs; an N site and a defect site are successfully introduced in a material synthesis stage and jointly play a role in catalyzing ozone to generate strong oxidation free radicals. The iron-nitrogen-carbon-based magnetic material is combined with O3, so that the drug removal rate and the ozone utilization rate can be greatly improved, and meanwhile, the regeneration of drug adsorption sites is completed. On the basis, under the working condition that 0.4 mg / L ozone is introduced, more than 90% of the 1.0 mg / L ibuprofen medicine can be removed by only consuming 5 minutes in the process.

The invention discloses a preparation method and application of magnetic microspheres for drug adsorption. Ferric salt is dissolved in water and heated, an alkaline agent is slowly dropwise added and stirred, cleaning is conducted after the reaction is finished, and Fe3O4 nanoparticles are prepared; the preparation method comprises the following steps: dispersing Fe3O4 nanoparticles in water, heating, adding a double-bond compound, and cleaning after the reaction is finished, so as to prepare Fe3O4 nanoparticles with-C = C-double bonds on the surface; fe3O4 nanoparticles with-C = C-double bonds on the surfaces are dispersed in water, an emulsifier and an active group compound are added, the active group compound is sodium p-styrenesulfonate, vinylpyrrolidone or triethyl (4-vinylbenzyl) ammonium chloride, continuous heating is performed, cleaning is performed after the reaction is finished, and the magnetic microspheres for drug adsorption are prepared. The magnetic microspheres can be fully mixed with sewage through the directional movement of the magnetic microspheres, adsorption, purification and concentration of drugs are completed through anion groups or cation groups, the operation steps of testing are greatly simplified, and the working efficiency is improved.

The invention discloses an alfentanil micro-dose injection based on clinical precise administration and a preparation method thereof, and relates to the technical field of pharmaceutical preparations, the injection is packaged by adopting a single-use small-capacity polypropylene (PP) material ampoule or a pre-filled syringe, the single package capacity is 0.5-2mL, the alfentanil micro-dose injection contains 0.1-50mu g / mL of alfentanil, and the injection is prepared by adopting a one-time injection method. The PP material has good high-temperature sterilization resistance and low drug adsorbability, so that the terminal sterilization requirement can be met, the drug stability can be ensured, and meanwhile, the risk of disengagement possibly caused by glass packaging is avoided; and finally, through an optimized packaging design and a preparation process, a simplified formula without preservatives and solubilizers is realized, and potential safety hazards possibly brought by auxiliary materials are reduced. According to the scheme, a safer and more economical accurate administration solution of the alfentanil is provided for clinic.

The invention discloses a pretreatment reagent for detecting sulfonamides in a sample, which is prepared by the following steps: adding 3, 4-diaminobenzophenone and 2-hydroxy-4-methoxybenzaldehyde into a cosolvent, and carrying out ultrasonic treatment; then adding a 2-hydracrylic acid aqueous solution for high-temperature reaction, washing and drying to obtain a grafted product; adding a coating agent into an ethanol water solution, performing ultrasonic treatment, adjusting the pH value to be alkaline to obtain a coating solution, immersing silicon dioxide aerogel into the coating solution, stirring, washing and drying to obtain a coating material; and adding the coating material and the grafted product into water, stirring, standing, washing with water, and freeze-drying to obtain the pretreatment reagent. Compared with the prior art, the pretreatment reagent prepared by the method has a better sulfonamide drug adsorption and recovery effect, and the reusability is improved.

The present invention provides a drug balloon and a preparation method thereof, including: providing a balloon body; pretreating the surface of the balloon body with a target reagent to improve the cleanliness and roughness of the surface of the balloon body; performing seeding treatment on the surface of the pretreated balloon body with a dispersion liquid containing nano-drug particles and a dispersant, so as to attach nano-drug particles to the surface of the balloon body in a physically adsorbed manner to form a seed layer; performing crystal growth treatment on the surface of the balloon body with a supersaturated solution of the active pharmaceutical ingredient to grow drug crystals precipitated from the saturated solution on the seed layer, which can adsorb pure drugs on the balloon surface without using excipients, is not easy to fall off, and is convenient for eluting and transferring drugs.

Provided are a well plate and a culture method which are excellent in ability to attach cells, etc., and exhibit a low drug adsorption property.The well plate including a bottom surface component and a well lateral wall component, wherein the bottom surface component and the well lateral wall component are bonded to each other to form at least one well, the bottom surface component and the well lateral wall component are formed of different materials, and a surface free energy of the well lateral wall component is 18.0 to 34.0 mN / m.

The application discloses a kind of nano composite hydrogel dressings with reversible adhesion-photothermal sterilization function and preparation method thereof.The preparation method includes the following:1) preparation of metal organic framework ZIF-8, which is immersed in a solution containing cyanidin CY-7 to achieve drug adsorption;DA is then used to coat the surface of the obtained sample to obtain ZIF-8 / CY-7 / PDA particles;2) preparation of 7-carboxymethoxyl-4-methyl coumarin CM with carboxyl at the end;3) through EDC coupling reaction, CM is grafted onto the side chain of dopamine-modified chitosan molecules to obtain CS-DA-CM;4) disperse ZIF-8 / CY-7 / PDA particles and angiogenic components in CS-DA-CM solution to obtain the dressing.The dressing can be injected and used, and can be gelled in situ to achieve adhesion when irradiated with a light source with a wavelength greater than 300 nm, and can be converted back to a solution when irradiated with a light source with a wavelength less than 280 nm;when an infrared wavelength with a wavelength of 820 nm is used, photothermal effect can be excited to achieve photothermal sterilization at the wound site, and photothermal effect can promote blood flow to accelerate wound healing.

The utility model relates to an anti-dropping cotton sliver for assisting in applying medicine to vagina before gynecological operation, which comprises a cotton sliver body, two sides of the cotton sliver body are correspondingly connected with fixing components, and each fixing component comprises a fixing ring and an elastic band. The fixing ring sleeves the outer side of the cotton sliver body, the inner diameter of the fixing ring is matched with the outer diameter of the cotton sliver body, and anti-slip lines are arranged on the inner side of the fixing ring to ensure that the cotton sliver body is stably fixed in the vagina. One end of the elastic band is connected with the fixing ring, the other end of the elastic band is provided with a sticking part, and the sticking part is made of a medical pressure-sensitive adhesive material, provided with an anti-allergy layer and used for being stuck to the perineum skin of a patient, so that the fixing effect is further enhanced. A drug sustained-release layer is arranged on the outer side of the cotton sliver body, the drug sustained-release layer is of a multi-layer structure and comprises a drug adsorption layer and a controlled-release film, the drug adsorption layer is used for adsorbing drugs, and the controlled-release film is used for controlling the release speed of the drugs, so that the drugs can be slowly and continuously released into the vagina, the drug concentration of the surgical site is improved, and the infection risk is reduced. The tail end of the cotton sliver body is provided with the pull ring to facilitate taking out.

The invention discloses a metoprolol succinate sustained-release micro-tablet filled capsule for children, belongs to the technical field of pharmaceutical preparations, and can effectively solve the problems of large dose error, difficulty in swallowing, serious blood concentration fluctuation and slow-release agent property of children. According to the invention, carboxylated hollow burr-shaped silicon dioxide powder is generated as one of the materials of the tablet core, and the hollow and burr structure of carboxylated hollow burr-shaped silicon dioxide not only increases the drug adsorption area, but also delays the drug dissolution through mechanical interlocking and steric hindrance effects, and cooperates with the sustained-release coating to form a dual sustained-release effect, so that the sustained-release effect of the tablet core is improved. The medicine effect lasting time is prolonged, and the medicine taking frequency is reduced.

The invention discloses a modified carbon-based adsorption material, a preparation method and application of the modified carbon-based adsorption material in drug adsorption. The modified carbon-based adsorption material is prepared from coffee grounds as a raw material through iron-zinc modification and pyrolysis. The material has a three-dimensional graphene biological carbon structure, Fe-Zn bimetallic oxide active sites are embedded in a carbon skeleton, the specific surface area is larger than 421 m < 2 > / g, a mesoporous structure is arranged in the carbon skeleton, and the static adsorption average removal rate on drugs in waste gas is larger than 85%. The preparation method comprises the following steps: (1) pretreating a coffee residue raw material; (2) modifying iron and zinc; (3) performing pyrolysis to obtain a modified carbon-based adsorption material; and (4) purifying to obtain the optimized modified carbon-based adsorption material. The use method comprises the following steps: (1) preparing the water-borne graphite powder absorption liquid; (2) contacting the waste gas with the absorption liquid; and (3) adsorbing drugs in the waste gas. The raw materials are cheap and easily available; the adsorption performance is excellent; the preparation process is controllable and can be amplified; the application range is wide.

The invention belongs to the field of developers, and particularly relates to developable particles as well as a preparation method and application thereof. The developable particle provided by the invention is prepared by taking iodine-containing alcohol as a main body through a physical crushing or reversed-phase emulsification cross-linking process, and can be used for directly loading a medicine and developing for a long time. Compared with embolism drug-loading microspheres sold in the market, the drug adsorption capacity of the developable particles is larger than or equal to 140 mg / g within 3 min, the adsorption rate within 1 d is larger than or equal to 90%, the developable particles have the functions of developing, rapid drug loading and controllable release, and the developable particles can be used for preparing tissue gasket drugs, tissue filling drugs, tumor vascular embolism drugs and radiotherapy labeling drugs.

The invention provides injectable hydrogel for promoting postoperative bone repair and preventing infection as well as a preparation method and application of the injectable hydrogel. The preparation method comprises the following steps: preparing carboxylated carbon quantum dots, and modifying the carboxylated carbon quantum dots with aminated PEG to obtain PEG-grafted carbon quantum dots; preparing a medicine composition solution consisting of ketorolac tromethamine, cowherb seed glycoside E and dioscin according to a weight ratio of (3 to 1) to (3 to 3), and adsorbing the medicine on the PEG-grafted carbon quantum dots; the preparation method comprises the following steps: adding a hydrogel solution which takes pullulan and human-like collagen as raw materials and precooled PBS as a solution, then adding a cross-linking agent, and heating to obtain the injectable hydrogel. According to the injectable hydrogel disclosed by the invention, a medicine composition with an obvious synergistic effect in the aspect of antibiosis is found, and the injectable hydrogel developed on the basis of the medicine composition not only has an effect of resisting bacterial infection, but also has an effect of promoting the increase of bone mineral density and improving bone repair after an orthopedic surgery, and has a relatively good application prospect.

The application discloses a medicinal glass bottle and a forming process thereof, and belongs to the technical field of medical materials, and comprises a glass bottle body and a composite coating of the inner wall of the glass bottle; the forming process comprises the following steps: 1) glass substrate pretreatment; 2) composite layer construction; 3) barrier layer construction; 4) cross-linking and inactivation and post-treatment. The inner wall coating designed in the application adopts a sandwich structure, realizes strong adhesion of a bottom layer through amino silane, realizes stable antibiosis by in-situ anchoring of silver nanoparticles through a branched polyethylene imine network, constructs a dense zwitterionic polymer brush on the outermost layer through surface-initiated polymerization, provides a super-hydrophilic and bio-inert surface, and finally, through cross-linking and inactivation treatment, the stability and safety of the coating are greatly improved. The application solves the problems of drug adsorption, microbial breeding and unstable coating existing in traditional packaging materials, and provides a safe and reliable new solution for medicine packaging.

The invention discloses a drug delivery system for preventing and treating scabies of Chinese softshell turtles. The system takes a bran bacillus compound as a carrier to load a therapeutic drug, and the bran bacillus compound is formed by compounding bacillus velezensis and bacillus amyloliquefaciens with Fengycin lipopeptide and yeast zinc respectively. The preparation method comprises the steps of carrier treatment, fungus compounding, medicine adsorption, drying and crushing and the like. According to the system, accurate matching of pathogenic bacteria and probiotics is achieved, mixed infection of aeromonas hydrophila, aeromonas veronii and the like can be synergistically inhibited, the dosage of antibiotics is reduced, and the residual risk is reduced. Drug release is optimized through the bran carrier, bioavailability is improved, environment regulation and body protection are both considered, and a'prevention-treatment-repair 'whole-process prevention and control system is formed. Clinical tests show that the cure rate reaches 91.5%, the safety is high, and an effective solution is provided for green prevention and control of the scabies of the Chinese softshell turtles.